44,753 research outputs found
Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain
Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism
Is Alice burning or fuzzing?
Recently, Almheiri, Marolf, Polchinski and Sully (AMPS) have suggested a
Gedankenexperiment to test black hole complementarity. They claim that the
postulates of black hole complementarity are mutually inconsistent and choose
to give up the "absence of drama" for an infalling observer. According to them
the black hole is shielded by a firewall no later than Page time. This has
generated some controversy. We find that an interesting picture emerges when we
take into account objections from the advocates of fuzzballs. We reformulate
AMPS' Gedankenexperiment in the decoherence picture of quantum mechanics and
find that low energy wave packets interact with the radiation quanta rather
violently while high energy wave packets do not. This is consistent with
Mathur's recent proposal of fuzzball complementarity for high energy quanta
falling into fuzzballs.Comment: 14 pages, 6 figures; v3: References added, discussions of some parts
changed substantially, conclusions unaltere
W' signatures with odd Higgs particles
We point out that W' bosons may decay predominantly into Higgs particles
associated with their broken gauge symmetry. We demonstrate this in a
renormalizable model where the W' and W couplings to fermions differ only by an
overall normalization. This "meta-sequential" W' boson decays into a scalar
pair, with the charged one subsequently decaying into a W boson and a neutral
scalar. These scalars are odd under a parity of the Higgs sector, which
consists of a complex bidoublet and a doublet. The W' and Z' bosons have the
same mass and branching fractions into scalars, and may show up at the LHC in
final states involving one or two electroweak bosons and missing transverse
energy.Comment: 24 page
Solving the More Difficult Aspects of Electric Motor Thermal Analysis in Small and Medium Size Industrial Induction Motors
With the ever-increasing pressure on electric motor manufacturers to develop smaller and more efficient electric motors, there is a need for more thermal analysis in parallel with the traditional electromagnetic design. Attention to the thermal design can be rewarded by major improvements in the overall performance. Technical papers published to date highlight a number of thermal design issues that are difficult to analyze. This paper reviews some of these issues and gives advice on how to deal with them when developing algorithms for inclusion in design software
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