2 research outputs found
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdul Rahim HF
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams RJ
- Aekplakorn W
- Afsana K
- Afzal S
- Agdeppa IA
- Aghazadeh-Attari J
- Aguilar-Salinas CA
- Agyemang C
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmadizar F
- Ahmed SH
- Ahrens W
- Ajlouni K
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Ali MM
- Alkandari A
- Alkerwi A
- Allin K
- Aly E
- Amarapurkar DN
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Anjana RM
- Ansari-Moghaddam A
- Ansong D
- Aounallah-Skhiri H
- Araújo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aspelund T
- Assah FK
- Assunção MCF
- Auvinen J
- Avdićová M
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Azmin M
- Babu BV
- Bahijri S
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banadinović M
- Bandosz P
- Banegas JR
- Baran J
- Barbagallo CM
- Barceló A
- Barkat A
- Barreto M
- Barros AJD
- Barros MVG
- Bartosiewicz A
- Basit A
- Bastos JLD
- Bata I
- Batieha AM
- Batyrbek A
- Baur LA
- Beaglehole R
- Belavendra A
- Ben Romdhane H
- Benet M
- Bennett JE
- Benson LS
- Berkinbayev S
- Bernabe-Ortiz A
- Bernotiene G
- Bettiol H
- Bezerra J
- Bhagyalaxmi A
- Bhargava SK
- Bia D
- Biasch K
- Bika Lele EC
- Bikbov MM
- Bista B
- Bjerregaard P
- Bjertness E
- Bjertness MB
- Björkelund C
- Bloch KV
- Blokstra A
- Bo S
- Bobak M
- Boeing H
- Boggia JG
- Boissonnet CP
- Bojesen SE
- Bongard V
- Bonilla-Vargas A
- Bopp M
- Borghs H
- Bovet P
- Boyer CB
- Braeckman L
- Brajkovich I
- Branca F
- Breckenkamp J
- Brenner H
- Brewster LM
- Briceño Y
- Brito M
- Bruno G
- Bueno G
- Bueno-de-Mesquita HB
- Bugge A
- Burns C
- Bursztyn M
- Cabrera de León A
- Cacciottolo J
- Cameron C
- Can G
- Capanzana MV
- Capuano E
- Capuano V
- Cardoso VC
- Carlsson AC
- Carrillo-Larco RM
- Carvalho J
- Casanueva FF
- Censi L
- Cervantes-Loaiza M
- Chadjigeorgiou CA
- Chamukuttan S
- Chan AW
- Chan Q
- Chaturvedi HK
- Chaturvedi N
- Chee ML
- Chen C-J
- Chen F
- Chen H
- Chen S
- Chen Z
- Cheng C-Y
- Cheraghian B
- Cherkaoui Dekkaki I
- Chetrit A
- Chien K-L
- Chiolero A
- Chiou S-T
- Chirita-Emandi A
- Chirlaque M-D
- Cho B
- Christensen K
- Christofaro DG
- Chudek J
- Cifkova R
- Cinteza E
- Claessens F
- Clarke J
- Clays E
- Cohen E
- Concin H
- Cooper C
- Coppinger TC
- Costanzo S
- Cottel D
- Cowan MJ
- Cowell C
- Craig CL
- Crampin AC
- Crujeiras AB
- Cruz JJ
- Csilla S
- Cui L
- Cureau FV
- Cuschieri S
- Cândido APC
- D\u27Arrigo G
- d\u27Orsi E
- Dallongeville J
- Damasceno A
- Danaei G
- Dankner R
- Dantoft TM
- Dauchet L
- Davletov K
- De Backer G
- De Bacquer D
- De Curtis A
- de Gaetano G
- De Henauw S
- de Oliveira PD
- De Ridder D
- De Smedt D
- Deepa M
- Deev AD
- DeGennaro VJ
- Delisle H
- Demarest S
- Dennison E
- Deschamps V
- Dhimal M
- Di Castelnuovo AF
- Dias-da-Costa JS
- Diaz A
- Dickerson TT
- Dika Z
- Djalalinia S
- Do HTP
- Dobson AJ
- Donfrancesco C
- Donoso SP
- Dorobantu M
- Doua K
- Dragano N
- Drygas W
- Duante CA
- Duboz P
- Duda RB
- Dulskiene V
- Dushpanova A
- Dzerve V
- Dziankowska-Zaborszczyk E
- Döring A
- Dörr M
- Džakula A
- Eddie R
- Eftekhar E
- Eggertsen R
- Eghtesad S
- Eiben G
- Ekelund U
- El Ati J
- El-Khateeb M
- Eldemire-Shearer D
- Eliasen M
- Elliott P
- Elosua R
- Erasmus RT
- Erbel R
- Erem C
- Eriksen L
- Eriksson JG
- Escobedo-de la Peña J
- Eslami S
- Esmaeili A
- Evans A
- Faeh D
- Fakhretdinova AA
- Fall CH
- Faramarzi E
- Farjam M
- Farzadfar F
- Fattahi MR
- Fawwad A
- Felix SB
- Felix-Redondo FJ
- Ferguson TS
- Fernandes RA
- Fernández-Bergés D
- Ferrante D
- Ferrao T
- Ferrari M
- Ferrario MM
- Ferreccio C
- Ferreira HS
- Ferrer E
- Ferrieres J
- Figueiró TH
- Fink G
- Fischer K
- Foo LH
- Forsner M
- Fouad HM
- Francis DK
- Franco MDC
- Frikke-Schmidt R
- Frontera G
- Fuchs FD
- Fuchs SC
- Fujita Y
- Fumihiko M
- Furdela V
- Furer A
- Furusawa T
- Gaciong Z
- Galbarczyk A
- Galenkamp H
- Galvano F
- Gao J
- Gao P
- Garcia P
- Garcia-de-la-Hera M
- Gareta D
- Garnett SP
- Gaspoz J-M
- Gasull M
- Gazzinelli A
- Gehring U
- Geleijnse JM
- George R
- Ghanbari A
- Ghasemi E
- Gheorghe-Fronea O-F
- Ghimire A
- Gialluisi A
- Giampaoli S
- Gieger C
- Gill TK
- Giovannelli J
- Gironella G
- Giwercman A
- Gkiouras K
- Goldberg M
- Goldsmith RA
- Gomez LF
- Gomula A
- Gonzalez AR
- Gonzalez-Chica DA
- Gonzalez-Gross M
- González-Rivas JP
- González-Villalpando C
- González-Villalpando M-E
- Gonçalves Cordeiro da Silva B
- Gonçalves H
- Gonçalves M
- Gorbea MB
- Gottrand F
- Graff-Iversen S
- Grafnetter D
- Grajda A
- Grammatikopoulou MG
- Gregg EW
- Gregor RD
- Grodzicki T
- Grosso G
- Gruden G
- Gu D
- Guan OP
- Gudmundsson EF
- Gudnason V
- Guerrero R
- Guessous I
- Guimaraes AL
- Gulliford MC
- Gunnlaugsdottir J
- Gunter MJ
- Gupta PC
- Gupta R
- Gureje O
- Gurzkowska B
- Gutierrez L
- Gutzwiller F
- Ha S
- Hadaegh F
- Haghshenas R
- Hakimi H
- Halkjær J
- Hambleton IR
- Hamzeh B
- Hange D
- Hanif AAM
- Hantunen S
- Hao J
- Hardman CM
- Hari Kumar R
- Hashemi-Shahri SM
- Hata J
- Haugsgjerd T
- Hayes AJ
- He J
- He Y
- Heier M
- Hendriks ME
- Henrique RDS
- Henriques A
- Hernandez Cadena L
- Herqutanto
- Herrala S
- Heshmat R
- Hill AG
- Ho SC
- Ho SY
- Hobbs M
- Holdsworth M
- Homayounfar R
- Horasan Dinc G
- Horimoto ARVR
- Hormiga CM
- Horta BL
- Houti L
- Howitt C
- Htay TT
- Htet AS
- Htike MMT
- Hu Y
- Huerta JM
- Huhtaniemi IT
- Huiart L
- Huisman M
- Husseini AS
- Huybrechts I
- Hwalla N
- Iacoviello L
- Iannone AG
- Ibrahim Wong N
- Ibrahim MM
- Ikeda N
- Ikram MA
- Iotova V
- Irazola VE
- Ishida T
- Isiguzo GC
- Islam M
- Islam SMS
- Iurilli MLC
- Iwasaki M
- Jackson RT
- Jacobs JM
- Jaddou HY
- Jafar T
- James K
- Jamrozik K
- Janszky I
- Janus E
- Jarvelin M-R
- Jasienska G
- Jelaković A
- Jelaković B
- Jennings G
- Jha AK
- Jiang CQ
- Jimenez RO
- Joffres M
- Johansson M
- Jokelainen JJ
- Jonas JB
- Joshi P
- Joukar F
- Juolevi A
- Jurak G
- Jureša V
- Jóżwiak J
- Jöckel K-H
- Jørgensen T
- Kaaks R
- Kafatos A
- Kajantie EO
- Kalmatayeva Z
- Kalpourtzi N
- Kalter-Leibovici O
- Kampmann FB
- Kannan S
- Karaglani E
- Karki KB
- Katibeh M
- Katz J
- Kauhanen J
- Kaur P
- Kavousi M
- Kazakbaeva GM
- Keil U
- Keinan Boker L
- Keinänen-Kiukaanniemi S
- Kelishadi R
- Kemper HCG
- Kengne AP
- Keramati M
- Kerimkulova A
- Kersting M
- Key T
- Khader YS
- Khalili D
- Khang Y-H
- Khaw K-T
- Kheiri B
- Kheradmand M
- Khosravi A
- Kiechl S
- Kiechl-Kohlendorfer U
- Killewo J
- Kim DW
- Kim HC
- Kim J
- Klakk H
- Klimek M
- Klumbiene J
- Knoflach M
- Kolle E
- Kolsteren P
- Kontto JP
- Korpelainen R
- Korrovits P
- Kos J
- Koskinen S
- Kouda K
- Kowlessur S
- Koziel S
- Kratenova J
- Kriaucioniene V
- Kristensen PL
- Krokstad S
- Kromhout D
- Kruger HS
- Kubinova R
- Kuciene R
- Kujala UM
- Kulaga Z
- Kumar RK
- Kurjata P
- Kusuma YS
- Kutsenko V
- Kuulasmaa K
- Kyobutungi C
- Kårhus LL
- Laatikainen T
- Lachat C
- Laid Y
- Lam TH
- Landrove O
- Lanska V
- Lappas G
- Larijani B
- Latt TS
- Laxmaiah A
- Le Coroller G
- Le Nguyen Bao K
- Le TD
- Lee J
- Lee J
- Lehmann N
- Lehtimäki T
- Lemogoum D
- Levitt NS
- Lhoste VPF
- Li Y
- Lilly CL
- Lim W-Y
- Lima-Costa MF
- Lin H-H
- Lin X
- Lin Y-T
- Lind L
- Lingam V
- Linneberg A
- Lissner L
- Litwin M
- Lo W-C
- Loit H-M
- Lopez T
- Lopez-Garcia E
- Lotufo PA
- Lozano JE
- Lukačević Lovrenčić I
- Lukrafka JL
- Luksiene D
- Lundqvist A
- Lundqvist R
- Lunet N
- Lustigová M
- Luszczki E
- Ma G
- Ma J
- Machado-Coelho GLL
- Machado-Rodrigues AM
- Macia E
- Macieira LM
- Madar AA
- Maggi S
- Magliano DJ
- Magriplis E
- Mahasampath G
- Maire B
- Majer M
- Makdisse M
- Malekzadeh F
- Malekzadeh R
- Malhotra R
- Mallikharjuna Rao K
- Malyutina SK
- Maniego LV
- Manios Y
- Mann JI
- Mansour-Ghanaei F
- Manzato E
- Marcil A
- Margozzini Maira P
- Marinović Glavić M
- Marques LP
- Marques-Vidal P
- Marrugat J
- Martorell R
- Mascarenhas LP
- Matasin M
- Mathiesen EB
- Mathur P
- Matijasevich A
- Matlosz P
- Matsha TE
- Mavrogianni C
- Mbanya JCN
- Mc Donald Posso AJ
- McFarlane SR
- McGarvey ST
- McLachlan S
- McLean RM
- McLean SB
- McNulty BA
- Mediene Benchekor S
- Medzioniene J
- Mehdipour P
- Mehlig K
- Mehrparvar AH
- Meirhaeghe A
- Meisinger C
- Mendoza Montano C
- Menezes AMB
- Menon GR
- Mereke A
- Meshram II
- Metspalu A
- Meyer HE
- Mi J
- Michels N
- Mikkel K
- Milkowska K
- Miller JC
- Minderico CS
- Mini GK
- Miranda JJ
- Mirjalili MR
- Mirrakhimov E
- Mišigoj-Duraković M
- Modesti PA
- Moghaddam SS
- Mohajer B
- Mohamed MK
- Mohamed SF
- Mohammad K
- Mohammadi MR
- Mohammadi Z
- Mohammadifard N
- Mohammadpourhodki R
- Mohan V
- Mohanna S
- Mohd Yusoff MF
- Mohebbi I
- Mohebi F
- Moitry M
- Molnár D
- Momenan A
- Mondo CK
- Monterrubio-Flores E
- Monyeki KDK
- Moon JS
- Moosazadeh M
- Moreira LB
- Morejon A
- Moreno LA
- Morgan K
- Moschonis G
- Mossakowska M
- Mostafa A
- Mostafavi S-A
- Mota J
- Motlagh ME
- Motta J
- Moura-dos-Santos MA
- Mridha MK
- Msyamboza KP
- Mu TT
- Muhihi AJ
- Muiesan ML
- Murphy N
- Mursu J
- Musa KI
- Musil V
- Musić Milanović S
- Mustafa N
- Mårild SB
- Møllehave LT
- Müller-Nurasyid M
- Nabipour I
- Naderimagham S
- Nagel G
- Naidu BM
- Najafi F
- Nakamura H
- Nang EEK
- Nangia VB
- Narake S
- Ndiaye NC
- Neal WA
- Nejatizadeh A
- Nenko I
- Neovius M
- Neuhauser H
- Nguyen CT
- Nguyen ND
- Nguyen QN
- Nguyen QV
- Nieto-Martínez RE
- Niiranen TJ
- Nikitin YP
- Ninomiya T
- Nishtar S
- Njelekela MA
- Noale M
- Noboa OA
- Noorbala AA
- Norat T
- Nordendahl M
- Nordestgaard BG
- Noto D
- Nowak-Szczepanska N
- Nsour MA
- Nunes B
- Námešná J
- O\u27Neill TW
- O\u27Reilly D
- Ochimana C
- Oda E
- Odili AN
- Oh K
- Ohara K
- Ohtsuka R
- Olinto MTA
- Oliveira IO
- Olié V
- Omar MA
- Onat A
- Ong SK
- Ono LM
- Ordunez P
- Ornelas R
- Ortiz PJ
- Osmond C
- Ostojic SM
- Ostovar A
- Otero JA
- Overvad K
- Owusu-Dabo E
- Paccaud FM
- Paciorek CJ
- Padez C
- Pahomova E
- Paiva KMD
- Pająk A
- Palli D
- Palmieri L
- Pan W-H
- Panda-Jonas S
- Panza F
- Paoli M
- Papandreou D
- Park S
- Park S-W
- Parnell WR
- Parsaeian M
- Pasquet P
- Patel ND
- Pavlyshyn H
- Pednekar MS
- Pedro JM
- Peer N
- Peixoto SV
- Peltonen M
- Pereira AC
- Peres KGDA
- Peres MA
- Peters A
- Petkeviciene J
- Peykari N
- Pećin I
- Pham ST
- Pichardo RN
- Pigeot I
- Pikhart H
- Pilav A
- Pilotto L
- Pitakaka F
- Piwonska A
- Pizarro AN
- Plans-Rubió P
- Polašek O
- Porta M
- Poudyal A
- Pourfarzi F
- Pourshams A
- Poustchi H
- Pradeepa R
- Price AJ
- Price JF
- Providencia R
- Puhakka SE
- Puiu M
- Punab M
- Qasrawi RF
- Qorbani M
- Queiroz D
- Quoc Bao T
- Ra
- Radisauskas R
- Radić I
- Rahimikazerooni S
- Rahman M
- Raitakari O
- Raj M
- Rakhimova EM
- Riley LM
- Savin S
- Singleton RK
- Solomon B
- Sophiea MK
- Stevens GA
- Sundström J
- Varghese C
- Widyahening IS
- Woodward M
- Zdrojewski T
- Zhou B
- Čapková N
- Publication venue
- 'Elsevier BV'
- Publication date
- 11/09/2021
- Field of study
A community effort to discover small molecule SARS-CoV-2 inhibitors
- Author
- Abraham Muñiz-Chicharro
- Adolfo García-Sastre
- Agamemnon K. Krasoulis
- Agnès Zettor
- Alexander V. Veselovsky
- Alexander Medvedev
- Alexandre Varnek
- Alexandros Tsengenes
- Amanda Embree
- Amit Singh
- Amitava Roy
- Anastassia V. Rudik
- Andrea Beccari
- Andreas Mayr
- Anna D. Karpenko
- Anton Hanke
- Anton Maliutin
- Ariane Nunes-Alves
- Artsemi Yushkevich
- Arturo Casini
- Ashutosh Kumar
- Babak Falsafi
- Beatrice Charton
- Benjamin P. Joseph
- Bertrand C. Cirou
- Bryan Ford
- Candida Manelfi
- Carmine Talarico
- Chamali H. Narangoda
- Charles L. Brooks III
- Cheng-Hao Liu
- Christian Gruber
- Christina Athanasiou
- Christina Halmich
- Christoph Gorgulla
- Christopher A. Voigt
- Conner Copeland
- D. Benjamin Gordon
- Daniel R. Olson
- Daren Fearon
- Daria B. Kokh
- David Lei
- Dmitry A. Filimonov
- Dmitry S. Druzhilovskiy
- Dragos Horvath
- Eleonora Gianquinto
- Emmanuel Bengio
- Enrico Glaab
- Evgeny M. Gutkin
- Filipp Gusev
- Florian Kaiser
- Francesca Spyrakis
- Francesco Musiani
- Francois Berenger
- Frank Noé
- Frank Von Delft
- Georg Steinkellner
- Gerhard Wagner
- Giada De Simone
- Gilles Marcou
- Giulia D\u27Arrigo
- Giulia Paiardi
- Giulia Rossetti
- Goutam Mukherjee
- Guilhem Tesseyre
- Gérard Gil
- Günter Klambauer
- Hamid Eghbal-zadeh
- Haribabu Arthanari
- Hatice Gokcan
- Igor Kozlovskii
- Ivan P. Bosko
- Jamie E. Kinney
- Jeremiah Gaiser
- Jessica Lombino
- Johannes Schimunek
- Jonas Goßen
- Kam Y.J. Zhang
- Karl Gruber
- Katarina Elez
- Katelin Pratt
- Kelly Barnsley
- Klara Blaschitz
- Konstantin V. Furs
- Konstantin Fackeldey
- Kris M. White
- Krishna M. Padmanabha Das
- Kuang-Yu Chen
- Leonid A. Stolbov
- Lluís Raich
- Luisa Pugliese
- M. Luis Rodríguez
- Maksym Korablyov
- Marco Cespugli
- Maria G. Kurnikova
- Maria R. Gulotta
- Maria De Rosa
- Mark Zaretckii
- Martin A. Walsh
- Mary Jo Ondrechen
- Michael Hetmann
- Michael Schroeder
- Michael Widrich
- Mikita Shuldau
- Mohammed B. Benabderrahmane
- Moksh J. Jain
- Nadia Naffakh
- Nedra Mekni
- Nick A. Antonopoulos
- Nikolaos E. Epitropakis
- Olexandr Isayev
- Paolo Carloni
- Patrick D. Fischer
- Patrick Bousquet-Melou
- Pavel V. Pogodin
- Peter Ruch
- Petr Popov
- Philipp Seidl
- Pierre Lafaye
- Rebecca C. Wade
- Robin Winter
- Roman Zubatyuk
- Ronan Bureau
- Ryan J. Yust
- S. Kashif Sadiq
- Sandra Kovachka
- Sang Yup Lee
- Sepp Hochreiter
- Shreya Pandita
- Simon Olsson
- Simone Albani
- Stanley Watowich
- Stavros T. Theodorakis
- Suhasini M. Iyengar
- Suman Sirimulla
- Thomas M. Hermans
- Tim Hempel
- Tim Krischuns
- Travis J. Wheeler
- Tuan Le
- Ugo Perricone
- V. Joachim Haupt
- Vassilis P. Pitsikalis
- Vedat Durmaz
- Vishwesh Venkatraman
- Vladimir Poroikov
- William J. Allen
- Yoshihiro Yamanishi
- Yoshua Bengio
- Yury V. Kornoushenko
- Yves Jacob
- Zi-Fu Wang
- Publication venue
- Publication date
- 07/04/2023
- Field of study
The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of a community effort, the “Billion molecules against Covid-19 challenge”, to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 potentially active molecules, which were subsequently ranked to find ‘consensus compounds’. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (Nsp12 domain), and (alpha) spike protein S. Overall, 27 potential inhibitors were experimentally confirmed by binding-, cleavage-, and/or viral suppression assays and are presented here. All results are freely available and can be taken further downstream without IP restrictions. Overall, we show the effectiveness of computational techniques, community efforts, and communication across research fields (i.e., protein expression and crystallography, in silico modeling, synthesis and biological assays) to accelerate the early phases of drug discovery