5 research outputs found
ΠΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π³Π΅Π½Π° Π°Π΄ΠΈΠΏΠΎΠ½ΡΡΡΠΈΠ½Π° (PNPLAΠ) Ρ ΠΊΠΎΡΠ΅Π½Π½ΡΡ ΠΆΠΈΡΠ΅Π»Π΅ΠΉ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ Π‘Π°Ρ Π° (Π―ΠΊΡΡΠΈΡ), ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ ΡΠ°Ρ Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 2-Π³ΠΎ ΡΠΈΠΏΠ°
Rationale: The association of rs738409 I148M polymorphism with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease has been confirmed for several ethnic and territorial groups. Up to now, no such studies have been performed in the populations of Yakutia.Aim: To study allele frequency distribution and to identify associations of the PNPLA3 gene polymorphism (rs738409 CG) with T2DM in the Yakuts.Materials and methods: DNA samples from 106Β T2DM patients were used in the study; the control group included samples from 72 healthy volunteers. All study participants were ethnic Yakuts and were living in the territory of the Republic of Sakha (Yakutia), Russian Federation. rs738409 polymorphism of the PNPLA3 gene was studied by polymerase chain reaction and by restriction fragment length polymorphism.Results: There were no significant difference in the distribution of the allele frequencies and genotypes of the polymorphous variant of the PNPLA3 gene (rs738409) between the T2DM patients and the healthy control. Both groups showed prevailing allele G (Ρ = 0.01) and homozygous genotype GG (96%).Conclusion: High frequency of the allele G (74.1%) with predominance of GG genotype (58.5%) was found in type 2 diabetic patients.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΡΠΎΡΠΈΠ°ΡΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° rs738409 I148M ΡΒ ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 2-Π³ΠΎΒ ΡΠΈΠΏΠ° (Π‘Π2) ΠΈΒ Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ Π±ΡΠ»Π° ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π²Β Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΒ Π³Π΅ΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. ΠΠΎ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π²Β ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
Π―ΠΊΡΡΠΈΠΈ ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ.Π¦Π΅Π»ΡΒ β ΠΈΠ·ΡΡΠΈΡΡ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠΎΡ Π°Π»Π»Π΅Π»Π΅ΠΉ ΠΈΒ Π²ΡΡΠ²ΠΈΡΡ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° Π³Π΅Π½Π° PNPLA3 (rs738409 CG) ΡΒ Π‘Π2 ΡΒ ΡΠΊΡΡΠΎΠ².ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ.Β ΠΠ»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΎΠ±ΡΠ°Π·ΡΡ ΠΠΠ 106Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π‘Π2, Π³ΡΡΠΏΠΏΠΎΠΉ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠ»ΡΠΆΠΈΠ»Π° Π²ΡΠ±ΠΎΡΠΊΠ° ΠΈΠ· 72Β Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΠ΅Π². ΠΡΠ΅ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ½ΠΎΡΡΠΈ Π±ΡΠ»ΠΈ ΡΠΊΡΡΠ°ΠΌΠΈ ΠΈΒ ΠΏΡΠΎΠΆΠΈΠ²Π°Π»ΠΈ Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ Π‘Π°Ρ
Π° (Π―ΠΊΡΡΠΈΡ). ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° rs738409 Π³Π΅Π½Π° PNPLA3 ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈΒ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π΄Π»ΠΈΠ½ ΡΠ΅ΡΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡ Π°Π»Π»Π΅Π»Π΅ΠΉ ΠΈΒ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° Π³Π΅Π½Π° PNPLA3 (rs738409) Π²Β Π³ΡΡΠΏΠΏΠ°Ρ
Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π2 ΠΈΒ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π½Π΅ Π²ΡΡΠ²ΠΈΠ» ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ, Π²Β ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π» Π°Π»Π»Π΅Π»Ρ G (Ρ = 0,01) ΠΈΒ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΠΉ Π³Π΅Π½ΠΎΡΠΈΠΏ GG (96%).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£Β Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π2 ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ ΡΠ°ΡΡΠΎΡΠ° Π°Π»Π»Π΅Π»ΡΒ G (74,1%) ΡΒ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° GG (58,5%)