Spectral Methods and Running Scales in Causal Dynamical Triangulations

The spectrum of the Laplace-Beltrami operator, computed on the spatial slices of Causal Dynamical Triangulations, is a powerful probe of the geometrical properties of the configurations sampled in the various phases of the lattice theory. We study the behavior of the lowest eigenvalues of the spectrum and show that this can provide information about the running of length scales as a function of the bare parameters of the theory, hence about the critical behavior around possible second order transition points in the CDT phase diagram, where a continuum limit could be defined.Comment: 5 pages, 6 figure

Infectious aetiology of marginal zone lymphoma and role of anti-infective therapy

Marginal zone lymphomas have been associated with several infectious agents covering both viral and bacterial pathogens and in some cases a clear aetiological role has been established. Pathogenetic mechanisms are currently not completely understood. However, the role of chronic stimulation of the host immune response with persistent lymphocyte activation represents the most convincing explanation for lymphoproliferation. Gastric MALT lymphoma is strictly associated with Helicobacter pylori infection and various eradicating protocols, developed due to increasing antibiotic resistance, represent the first line therapy for gastric MALT. The response rate to eradication is good with 80% of response at 1 year; this finding is also noteworthy because it recapitulates cancer cured only by the antibacterial approach and it satisfies the Koch postulates of causation, establishing a causative relationship between Hp and gastric MALT lymphoma. Patients with chronic HCV infection have 5 times higher risk to develop MZL, in particular, an association with splenic and nodal MZL has been shown in several studies. Moreover, there is evidence of lymphoma regression after antiviral therapy with interferon+ribavirin, thus raising hope that newly available drugs, extremely efficient against HCV replication, could improve outcome also in HCV-driven lymphomas. Another case-study are represented by those rare cases of MZL localized to orbital fat and eye conjunctivas that have been associated with Chlamydophila psittaci infection carried by birds. Efficacy of antibacterial therapy against C. psittaci are conflicting and generally poorer than gastric MALT. Finally, some case reports will cover the relationship between primary cutaneous B-cell Lymphomas and Borrelia Burgdorferi

On the analytic continuation of the critical line

We perform a numerical study of the systematic effects involved in the determination of the critical line at real baryon chemical potential by analytic continuation from results obtained at imaginary chemical potentials. We present results obtained in a theory free of the sign problem, three-color QCD with finite isospin chemical potential, and comment on general features which could be relevant also to the continuation of the critical line in real QCD at finite baryon density.Comment: 7 pages, 3 figures, Contribution to The XXVII International Symposium on Lattice Field Theory, Beijing, July 25-31, 200

Analysis of pregnancy-associated plasma protein a production in human adult cardiac progenitor cells

IGF-binding proteins (IGFBPs) and their proteases regulate IGFs bioavailability in multiple tissues. Pregnancy-associated plasma protein A (PAPP-A) is a protease acting by cleaving IGFBP2, 4, and 5, regulating local bioavailability of IGFs. We have previously shown that IGFs and IGFBPs are produced by human adult cardiac progenitor cells (haCPCs) and that IGF-1 exerts paracrine therapeutic effects in cardiac cell therapy with CPCs. Using immunofluorescence and enzyme immunoassays, we firstly report that PAPP-A is produced and secreted in surprisingly high amounts by haCPCs. In particular, the homodimeric, enzymatically active, PAPP-A is secreted in relevant concentrations in haCPC-conditioned media, while the enzymatically inactive PAPPA/proMBP complex is not detectable in the same media. Furthermore, we show that both homodimeric PAPP-A and proMBP can be detected as cell associated, suggesting that the previously described complex formation at the cell surface does not occur easily, thus positively affecting IGF signalling. Therefore, our results strongly support the importance of PAPP-A for the IGFs/IGFBPs/PAPP-A axis in CPCs biology

Transdural Spread of Glioblastoma with Endonasal Growth in a Long-Term Survivor Patient: Case Report and Literature Review.

Glioblastoma (GBM) is the most aggressive primary tumor of the central nervous system (CNS) in adults. Its growth has been always described as locally invasive. This tumor rarely penetrates dura mater and invades extracranial structures. We present a case of GBM, which occurred in a 39-year-old man, with final involvement of the nasal cavity. The patient was operated four times in three years, and a personalized adjuvant chemotherapy regimen was administered in a neo-adjuvant fashion. Histopathological features of the tumor are described. To our knowledge, there are only 9 cases reported in the literature showing this growth pattern and the last case was reported in 1998

Spectral Methods in Causal Dynamical Triangulations

We show recent results of the application of spectral analysis in the setting of the Monte Carlo approach to Quantum Gravity known as Causal Dynamical Triangulations (CDT), discussing the behavior of the lowest lying eigenvalues of the Laplace-Beltrami operator computed on spatial slices. This kind of analysis provides information about running scales of the theory and about the critical behaviour around a possible second order transition in the CDT phase diagram, discussing the implications for the continuum limit.Comment: Proceeding of Science for parallel talk at the 37th International Symposium on Lattice Field Theory - Lattice2019, 16-22 June 2019, Wuhan, Chin

Insights into pharmacotherapy of malignant glioma in adults

Malignant gliomas are the most common primary brain tumors in adults. In the past 10 years significant advances in the treatment of this entity have been made, mainly owing to a better understanding of molecular pathways and biological behavior of the oncogenetic process. This review treats the proven effective and promising approaches with chemotherapy. The standard care for glioblastoma is surgery and concomitant radio- and chemotherapy with temozolomide (TMZ), followed by adjuvant treatment with TMZ. It has been demonstrated to be the most effective treatment protocol. This standardized care allows the application and study of new types of treatment mainly in recurrences and nonresponding patients. Many different approaches have been investigated: the combination of cytotoxic and cytostatic agents as well as molecular targeted therapies have given some encouraging results. Further intensified regimens with TMZ and the local postsurgical application of slow-release polymers loaded with carmustine remain to be defined. The characterization of molecular markers thus becomes particularly important for the stratification of patients raising the possibility to individualize treatment

Analysing firm's evolution: discontinuity and growth

Typically, firms change their size through a row of discrete leaps over time. A very basic model allowing for discontinuous growth can be based on a couple of assumptions: (a) in the short run, the firm’s equipment and organization provide the maximum profit only for a given production level, and diverging form it is costly; and (b) in the long run, the firm adjusts its size as if the current equipment had to be exploited until overall profits exceed a given threshold and those expected from the new desired plant for the current production level. Combining the latter two hypotheses entails a number of testable consequences, usually regarded as nuisance facts according to the traditional theories. First of all, the profitability should not be a continuous function of the firms’ size, but exhibits a number of peaks, each corresponding to a different locally optimal size. Secondly, when demand is growing, investment are expected to increase just when profits falls shorter some given threshold. The model has been tested by using a panel of data on the size and performances of Italian manufacturing firms from 1998 to 2007. Indeed, both the non-parametric analysis and a panel estimation confirm the presence of several “peaks” in the distribution of profitability by size. Furthermore, a negative statistical relationship is apparent between investment and profitability, controlling for the size of firms.Capacity utilization; Discontinuity; Firm’s size; Growth; Investment; Non parametric smoothing; Panel regression; Profit function

Climate and Human Health: Relations, Projections, and Future Implementations

It is widely accepted by the scientific community that the world has begun to warm as a result of human influence. The accumulation of greenhouse gases in the atmosphere, arising primarily from the combustion of carbon fossil fuels and agricultural activities, generates changes in the climate. Indeed various studies have assessed the potential impacts of climate change on human health (both negative and positive). The increased frequency and intensity of heat waves, the reduction in cold-related deaths, the increased floods and droughts, and the changes in the distribution of vector-borne diseases are among the most frequently studied effects. On the other hand, climate change differs from many other environmental health problems because of its gradual onset, widespread rather than localized effect, and the fact that the most important effects will probably be indirect. Some recent and important publications show that only the collaboration between the meteorological and the public health communities can help us to thoroughly study the link between climate and health, thus improving our ability to adapt to these future changes. The aim of this editorial is to give different perspectives on a widely discussed topic, which is still too complicated to be addressed to a satisfactory extent. Moreover, it is necessary to underline the importance of using new biometeorological indices (i.e. thermal indexes, etc.) for future projections, in order to reduce the impacts of negative outcomes, protecting the population through adaptation measures and public awareness