The Unreasonable Effectiveness of the Air-Fluorescence Technique in Determining the EAS Shower Maximum

We review all existing air-fluorescence measurements of the elongation rate of extensive air showers (slope of mean EAS shower maximum (Xmax) vs log of shower energy E) above 1017 eV. We find remarkable agreement for all current and historic experiments over a 30 year period for the energy range from 1017 to 3x1018 eV. The mean elongation rate in this energy interval is near 80 gm/cm2/decade Above this energy, experiments in the Northern hemisphere are in good agreement with an average elongation rate of 48 +/- 10 gm/cm2/decade while Southern hemisphere experiments have a flatter elongation rate of 26 +/- 2 gm/cm2/decade We point out that, given the agreement at lower energies, possible systematic reasons for this difference are unlikely. Given this, the world elongation rate data alone may indicate a composition difference of UHECR in the Northern and Southern hemisphere and thus a diversity of UHECR sources in the Northern and Southern sky.Comment: Accepted by JET

Multi-GeV Electron Generation Using Texas Petawatt Laser

We present simulation results and experimental setup for multi-GeV electron generation by a laser plasma wake field accelerator (LWFA) driven by the Texas Petawatt (TPW) laser. Simulations show that, in plasma of density n(e) = 2 - 4 x cm(-3), the TPW laser pulse (1.1 PW, 170 fs) can self-guide over 5 Rayleigh ranges, while electrons self-injected into the LWFA can accelerate up to 7 GeV. Optical diagnostic methods employed to observe the laser beam self-guiding, electron trapping and plasma bubble formation and evolution are discussed. Electron beam diagnostics, including optical transition radiation (OTR) and electron gamma ray shower (EGS) generation, are discussed as well.Physic

The Leucine Zipper Domains of the Transcription Factors GCN4 and c-Jun Have Ribonuclease Activity

Basic-region leucine zipper (bZIP) proteins are one of the largest transcription factor families that regulate a wide range of cellular functions. Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies. In the course of one such study, the X-ray structure of the retro-version of the LZ moiety of yeast transcriptional activator GCN4 suggested that this retro-LZ may have ribonuclease activity. Here we show that not only the retro-LZ but also the authentic LZ of GCN4 has weak but distinct ribonuclease activity. The observed cleavage of RNA is unspecific, it is not suppressed by the ribonuclease A inhibitor RNasin and involves the breakage of 3′,5′-phosphodiester bonds with formation of 2′,3′-cyclic phosphates as the final products as demonstrated by HPLC/electrospray ionization mass spectrometry. Several mutants of the GCN4 leucine zipper are catalytically inactive, providing important negative controls and unequivocally associating the enzymatic activity with the peptide under study. The leucine zipper moiety of the human factor c-Jun as well as the entire c-Jun protein are also shown to catalyze degradation of RNA. The presented data, which was obtained in the test-tube experiments, adds GCN4 and c-Jun to the pool of proteins with multiple functions (also known as moonlighting proteins). If expressed in vivo, the endoribonuclease activity of these bZIP-containing factors may represent a direct coupling between transcription activation and controlled RNA turnover. As an additional result of this work, the retro-leucine zipper of GCN4 can be added to the list of functional retro-peptides

Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices

Thermal injury triggers a fulminant inflammatory cascade that heralds shock, end-organ failure, and ultimately sepsis and death. Emerging evidence points to a critical role for the innate immune system, and several studies had documented concurrent impairment in neutrophil chemotaxis with these post-burn inflammatory changes. While a few studies suggest that a link between neutrophil motility and patient mortality might exist, so far, cumbersome assays have prohibited exploration of the prognostic and diagnostic significance of chemotaxis after burn injury. To address this need, we developed a microfluidic device that is simple to operate and allows for precise and robust measurements of chemotaxis speed and persistence characteristics at single-cell resolution. Using this assay, we established a reference set of migration speed values for neutrophils from healthy subjects. Comparisons with samples from burn patients revealed impaired directional migration speed starting as early as 24 hours after burn injury, reaching a minimum at 72–120 hours, correlated to the size of the burn injury and potentially serving as an early indicator for concurrent infections. Further characterization of neutrophil chemotaxis using this new assay may have important diagnostic implications not only for burn patients but also for patients afflicted by other diseases that compromise neutrophil functions

Single-server queueing systems with feedback

http://deepblue.lib.umich.edu/bitstream/2027.42/3336/5/bab3518.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/3336/4/bab3518.0001.001.tx

Queues with Instantaneous Feedback

Queueing problems in which a customer having received a unit of service, returns to the waiting line, under some decision rule, to receive another unit of service occur often in applications. Inspection procedures provide such a framework for units that must be reworked. A large class of such problems appears in computer modelling under the name of round-robin models and foreground-background models. In the present paper, such a system is referred to as a queue with instantaneous feedback. Throughout the text it is assumed that there are two independent Poisson arrival processes giving two types of customers. Each type of customer has its own service time distribution. The decision to feedback (to receive another unit of service) or not is based on the type of customer completing service. Conditions for the existence of a steady state queue length are found and some joint and marginal distribution of these queue lengths are given. Moreover it is shown that several earlier results in queueing and computer modelling can be obtained simply from the results given here. A particular case of the foreground-background model in computer systems analysis serves as an example.