VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides?

Although the VGF derived peptide TLQP-21 stimulates gonadotropin-releasing hormone (GnRH) and gonadotropin secretion, available data on VGF peptides and reproduction are limited. We used antibodies specific for the two ends of the VGF precursor, and for two VGF derived peptides namely TLQP and PGH, to be used in immunohistochemistry and enzyme-linked immunosorbent assay complemented with gel chromatography. In cycling female rats, VGF C-/N-terminus and PGH peptide antibodies selectively labelled neurones containing either GnRH, or kisspeptin (VGF N-terminus only), pituitary gonadotrophs and lactotrophs, or oocytes (PGH peptides only). Conversely, TLQP peptides were restricted to somatostatin neurones, gonadotrophs, and ovarian granulosa, interstitial and theca cells. TLQP levels were highest, especially in plasma and ovary, with several molecular forms shown in chromatography including one compatible with TLQP-21. Among the cycle phases, TLQP levels were higher during metestrus-diestrus in median eminence and pituitary, while increased in the ovary and decreased in plasma during proestrus. VGF N- and C-terminus peptides also showed modulations over the estrous cycle, in median eminence, pituitary and plasma, while PGH peptides did not. In ovariectomised rats, plasmatic TLQP peptide levels showed distinct reduction suggestive of a major origin from the ovary, while the estrogen-progesterone treatment modulated VGF C-terminus and TLQP peptides in the hypothalamus-pituitary complex. In in vitro hypothalamus, TLQP-21 stimulated release of growth hormone releasing hormone but not of somatostatin. In conclusion, various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary

Holocene slip rate variability along the Pernicana fault system (Mt. Etna, Italy): Evidence from offset lava flows

The eastern flank of the Mount Etna stratovolcano is affected by extension and is slowly sliding eastward into the Ionian Sea. The Pernicana fault system forms the border of the northern part of this sliding area. It consists of three E-W−oriented fault sectors that are seismically active and characterized by earthquakes up to 4.7 in magnitude (M) capable of producing ground rupture and damage located mainly along the western and central sectors, and by continuous creep on the eastern sector. A new topographic study of the central sector of the Pernicana fault system shows an overall bell-shaped profile, with maximum scarp height of 35 m in the center of the sector, and two local minima that are probably due to the complex morphological relation between fault scarp and lava flows. We determined the ages of lava flows cut by the Pernicana fault system at 12 sites using cosmogenic 3He and 40Ar/39Ar techniques in order to determine the recent slip history of the fault. From the displacement-age relations, we estimate an average throw rate of ∼2.5 mm/yr over the last 15 k.y. The slip rate appears to have accelerated during the last 3.5 k.y., with displacement rates of up to ∼15 mm/yr, whereas between 3.5 and 15 ka, the throw rate averaged ∼1 mm/yr. This increase in slip rate resulted in significant changes in seismicity rates, for instance, decreasing the mean recurrence time of M ≥ 4.7 earthquakes from ∼200 to ∼20 yr. Based on empirical relationships, we attribute the variation in seismic activity on the Pernicana fault system to factors intrinsic to the system that are likely related to changes in the volcanic system. These internal factors could be fault interdependencies (such as those across the Taupo Rift, New Zealand) or they could represent interactions among magmatic, tectonic, and gravitational processes (e.g., Kīlauea volcano, Hawaii). Given their effect on earthquake recurrence intervals, these interactions need to be fully assessed in seismic hazard evaluations

Aharonov-Bohm oscillations in a mesoscopic ring with a quantum dot

We present an analysis of the Aharonov-Bohm oscillations for a mesoscopic ring with a quantum dot inserted in one of its arms. It is shown that microreversibility demands that the phase of the Aharonov-Bohm oscillations changes {\it abruptly} when a resonant level crosses the Fermi energy. We use the Friedel sum rule to discuss the conservation of the parity of the oscillations at different conductance peaks. Our predictions are illustrated with the help of a simple one channel model that permits the variation of the potential landscape along the ring.Comment: 11 pages, Revtex style, 3 figures under request. Submitted to Phys. Rev. B (rapid communications

Comments on ‘output feedback adaptive command following and disturbance rejection for nonminimum phase uncertain dynamical systems’

We provide numerical examples and analysis to show that the adaptive controller given by Theorem 3.1 of Yucelen et al. 1 may fail to stabilize plants under the stated conditions. Copyright © 2011 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83465/1/1235_ftp.pd

Ontology Enrichment by Discovering Multi-Relational Association Rules from Ontological Knowledge Bases

International audienceIn the Semantic Web context, OWL ontologies represent the con-ceptualization of domains of interest while the corresponding as-sertional knowledge is given by the heterogeneous Web resources referring to them. Being strongly decoupled, ontologies and assertion can be out-of-sync. An ontology can be incomplete, noisy and sometimes inconsistent with regard to the actual usage of its conceptual vocabulary in the assertions. Data mining can support the discovery of hidden knowledge patterns in the data, to enrich the ontologies. We present a method for discovering multi-relational association rules, coded in SWRL, from ontological knowledge bases. Unlike state-of-the-art approaches, the method is able to take the intensional knowledge into account. Furthermore, since discovered rules are represented in SWRL, they can be straightforwardly integrated within the ontology, thus (i) enriching its expressive power and (ii) augmenting the assertional knowledge that can be derived. Discovered rules may also suggest new axioms to be added to the ontology. We performed experiments on publicly available ontologies validating the performances of our approach

Investigation of Cumulative Retrospective Cost Adaptive Control for Missile Application

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83634/1/AIAA-2010-7577-578.pd

Adaptive Output Feedback Control of the NASA GTM Model with Unknown Nonminimum-Phase Zeros

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90722/1/AIAA-2011-6204-387.pd

Green, circular, bio economy : A comparative analysis of sustainability avenues

Despite their evidently different assumptions and operationalization strategies, the concepts of Circular Economy, Green Economy and Bioeconomy are joined by the common ideal to reconcile economic, environmental and social goals. The three concepts are currently mainstreamed in academia and policy making as key sustainability avenues, but a comparative analysis of such concepts is missing. The aim of this article is thus to comprehensively analyse the diversity within and between such concepts. The results are drawn from a bibliometric review of almost two thousand scientific articles published within the last three decades, coupled with a conceptual analysis. We find that, for what concerns environmental sustainability, Green Economy acts as an 'umbrella' concept, including elements from Circular Economy and Bioeconomy concepts (e.g. eco-efficiency; renewables), as well as additional ideas, e.g. nature-based solutions. In particular, Circular Economy and Bioeconomy are resource-focused, whereas in principle Green Economy acknowledges the underpinning role of all ecological processes. Regarding the social dimension, Green Economy is more inclusive of some aspects at local level (e.g. eco-tourism, education), while there is an emerging discussion in Bioeconomy literature around local processes in terms of biosecurity and rural policies. When considering weak/strong sustainability visions, all concepts remain limited in questioning economic growth. By comparing the different sustainability strategies promoted by these concepts we do not advocate for their substitutability, but for their clarification and reciprocal integration. The findings are discussed in light of the concepts' synergies and limits, with the purpose to inform research and policy implementation. (C) 2017 The Authors. Published by Elsevier Ltd.Peer reviewe