Pre-main sequence stars with disks in the Eagle Nebula observed in scattered light

NGC6611 and its parental cloud, the Eagle Nebula (M16), are well-studied star-forming regions, thanks to their large content of both OB stars and stars with disks and the observed ongoing star formation. We identified 834 disk-bearing stars associated with the cloud, after detecting their excesses in NIR bands from J band to 8.0 micron. In this paper, we study in detail the nature of a subsample of disk-bearing stars that show peculiar characteristics. They appear older than the other members in the V vs. V-I diagram, and/or they have one or more IRAC colors at pure photospheric values, despite showing NIR excesses, when optical and infrared colors are compared. We confirm the membership of these stars to M16 by a spectroscopic analysis. The physical properties of these stars with disks are studied by comparing their spectral energy distributions (SEDs) with the SEDs predicted by models of T-Tauri stars with disks and envelopes. We show that the age of these stars estimated from the V vs. V-I diagram is unreliable since their V-I colors are altered by the light scattered by the disk into the line of sight. Only in a few cases their SEDs are compatible with models with excesses in V band caused by optical veiling. Candidate members with disks and photospheric IRAC colors are selected by the used NIR disk diagnostic, which is sensitive to moderate excesses, such as those produced by disks with low masses. In 1/3 of these cases, scattering of stellar flux by the disks can also be invoked. The photospheric light scattered by the disk grains into the line of sight can affect the derivation of physical parameters of ClassII stars from photometric optical and NIR data. Besides, the disks diagnostic we defined are useful for selecting stars with disks, even those with moderate excesses or whose optical colors are altered by veiling or photospheric scattered light.Comment: Accepted for publication in A&

Correlation between the spatial distribution of circumstellar disks and massive stars in the young open cluster NGC 6611. II: Cluster members selected with Spitzer/IRAC

Context: the observations of the proplyds in the Orion Nebula Cluster, showing clear evidence of ongoing photoevaporation, have provided a clear proof about the role of the externally induced photoevaporation in the evolution of circumstellar disks. NGC 6611 is an open cluster suitable to study disk photoevaporation, thanks to its large population of massive members and of stars with disk. In a previous work, we obtained evidence of the influence of the strong UV field generated by the massive cluster members on the evolution of disks around low-mass Pre-Main Sequence members. That work was based on a multi-band BVIJHK and X-ray catalog purposely compiled to select the cluster members with and without disk. Aims: in this paper we complete the list of candidate cluster members, using data at longer wavelengths obtained with Spitzer/IRAC, and we revisit the issue of the effects of UV radiation on the evolution of disks in NGC 6611. Methods: we select the candidate members with disks of NGC 6611, in a field of view of 33'x34' centered on the cluster, using IRAC color-color diagrams and suitable reddening-free color indices. Besides, using the X-ray data to select Class III cluster members, we estimate the disks frequency vs. the intensity of the incident radiation emitted by massive members. Results: we identify 458 candidate members with circumstellar disks, among which 146 had not been revealed in our previous work. Comparing of the various color indices we used to select the cluster members with disk, we claim that they detect the excesses due to the emission of the same physical region of the disk: the inner rim at the dust sublimation radius. Our new results confirm that UV radiation from massive stars affects the evolution of nearby circumstellar disks.Comment: Accepted for publication at Astronomy & Astrophysic

Use of Preputial Skin as Cutaneous Graft after Nevus Excision

We report a four-year-old boy with a nevus covering all the plantar side of his second finger on the left foot. He was also affected by congenital phimosis. Surgical excision of the nevus was indicated, but the skin defect would have been too large to be directly closed. The foreskin was taken as a full-thickness skin graft to cover the cutaneous defect of the finger. The graft intake was favourable and provided a functional repair with good aesthetic characteristic

Spitzer observations of the Orion OB1 association: disk census in the low mass stars

We present new Spitzer Space Telescope observations of two fields in the Orion OB1 association. We report here IRAC/MIPS observations for 115 confirmed members and 41 photometric candidates of the ~10 Myr 25 Orionis aggregate in the OB1a subassociation, and 106 confirmed members and 65 photometric candidates of the 5 Myr region located in the OB1b subassociation. The 25 Orionis aggregate shows a disk frequency of 6% while the field in the OB1b subassociation shows a disk frequency of 13%. Combining IRAC, MIPS and 2MASS photometry we place stars bearing disks in several classes: stars with optically thick disks (class II systems), stars with an inner transitional disks (transitional disk candidates) and stars with "evolved disks"; the last exhibit smaller IRAC/MIPS excesses than class II systems. In all, we identify 1 transitional disk candidate in the 25 Orionis aggregate and 3 in the OB1b field; this represents ~10% of the disk bearing stars, indicating that the transitional disk phase can be relatively fast. We find that the frequency of disks is a function of the stellar mass, suggesting a maximum around stars with spectral type M0. Comparing the infrared excess in the IRAC bands among several stellar groups we find that inner disk emission decays with stellar age, showing a correlation with the respective disk frequencies. The disk emission at the IRAC and MIPS bands in several stellar groups indicates that disk dissipation takes place faster in the inner region of the disks. Comparison with models of irradiated accretion disks, computed with several degrees of settling, suggests that the decrease in the overall accretion rate observed in young stellar groups is not sufficient to explain the weak disk emission observed in the IRAC bands for disk bearing stars with ages 5 Myr or older.Comment: Accepted in the Astrophysical Journa

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber)

Peptidylarginine deiminases (PADs) and extracellular vesicles (EVs) may be indicative biomarkers of physiological and pathological status and adaptive responses, including to diseases and disorders of the central nervous system (CNS) and related to hypoxia. While these markers have been studied in hypoxia-intolerant mammals, in vivo investigations in hypoxia-tolerant species are lacking. Naked mole-rats (NMR) are among the most hypoxia-tolerant mammals and are thus a good model organism for understanding natural and beneficial adaptations to hypoxia. Thus, we aimed to reveal CNS related roles for PADs in hypoxia tolerance and identify whether circulating EV signatures may reveal a fingerprint for adaptive whole-body hypoxia responses in this species. We found that following in vivo acute hypoxia, NMR: (1) plasma-EVs were remodelled, (2) whole proteome EV cargo contained more protein hits (including citrullinated proteins) and a higher number of associated KEGG pathways relating to the total proteome of plasma-EVs Also, (3) brains had a trend for elevation in PAD1, PAD3 and PAD6 protein expression, while PAD2 and PAD4 were reduced, while (4) the brain citrullinome had a considerable increase in deiminated protein hits with hypoxia (1222 vs. 852 hits in normoxia). Our findings indicate that circulating EV signatures are modified and proteomic content is reduced in hypoxic conditions in naked mole-rats, including the circulating EV citrullinome, while the brain citrullinome is elevated and modulated in response to hypoxia. This was further reflected in elevation of some PADs in the brain tissue following acute hypoxia treatment. These findings indicate a possible selective role for PAD-isozymes in hypoxia response and tolerance