Effect of tissue microenvironment on tumor growth and development.

<p>N202 and LLC tumor spheroids expressing H2B-GFP were implanted directly onto the dorsal skin or with mammary, liver or lung tissue as indicated and monitored through the dorsal skin window chamber by IVM at the indicated times.</p

Effect of mouse orthotopic tissue co-engraftment on human BT474 tumor growth.

<p>BT474 tumor spheroids expressing H2B-GFP were implanted directly onto the dorsal skin (sc) or with mouse mammary fat pad donor tissue (EO) and monitored by IVM. Tumor growth was measured by fluorescence signal over time. Mice received human estrogen supplement.</p

Effect of orthotopic tissue co-implantation on TRAMP C2 and MOVCAR16 tumor growth.

<p>Growth curves of TRAMPC2 and MOVCAR-16 tumor spheroids expressing H2B-GFP that were implanted directly onto the dorsal skin (sc) or with respective orthotopic donor tissue (EO) (prostate and ovary respectively) and monitored through the dorsal skin window chamber by IVM at the indicated times.</p

Effect of tissue co-engraftment on mitotic/apoptotic indices of tumor cells.

<p>Measurements of mitotic and apoptotic indicies in tissue from lung, breast, liver and skin.</p

Effect of tissue co-engraftment on tumor vascular development.

<p>N202 and LLC tumor vascular densities measured at the indicated times.</p