A text-mining system for extracting metabolic reactions from full-text articles

Background: Increasingly biological text mining research is focusing on the extraction of complex relationships relevant to the construction and curation of biological networks and pathways. However, one important category of pathway—metabolic pathways—has been largely neglected. Here we present a relatively simple method for extracting metabolic reaction information from free text that scores different permutations of assigned entities (enzymes and metabolites) within a given sentence based on the presence and location of stemmed keywords. This method extends an approach that has proved effective in the context of the extraction of protein–protein interactions. Results: When evaluated on a set of manually-curated metabolic pathways using standard performance criteria, our method performs surprisingly well. Precision and recall rates are comparable to those previously achieved for the well-known protein-protein interaction extraction task. Conclusions: We conclude that automated metabolic pathway construction is more tractable than has often been assumed, and that (as in the case of protein–protein interaction extraction) relatively simple text-mining approaches can prove surprisingly effective. It is hoped that these results will provide an impetus to further research and act as a useful benchmark for judging the performance of more sophisticated methods that are yet to be developed

Radiative-nonrecoil corrections of order alpha^2 (Z alpha) E_F to the hyperfine splitting of muonium

We present results for the corrections of order alpha^2 (Z alpha) E_F to the hyperfine splitting of muonium. We compute all the contributing Feynman diagrams in dimensional regularization and a general covariant gauge using a mixture of analytical and numerical methods. We improve the precision of previous results.Comment: 5 pages, 3 figures; v2: corrected several typos and replaced figure 3, final results and conclusions unchange

Radiative-nonrecoil corrections of order alpha^2 (Z alpha)^5 to the Lamb shift

We present results for the corrections of order alpha^2 (Z alpha)^5 to the Lamb shift. We compute all the contributing Feynman diagrams in dimensional regularization and a general covariant gauge using a mixture of analytical and numerical methods. We confirm results obtained by other groups and improve their precision. Values of the 32 master integrals for this and similar problems are provided.Comment: 8 pages, 4 figures; v2: added two references, changed comparison with previous result, conclusions unchanged, matches published version; v3: corrected typo in Table I, final results and conclusions unchange

Ultrastructural Observations on Bacterial Invasion in Cementum and Radicular Dentin of Periodontally Diseased Human Teeth

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141124/1/jper0493.pd

Constraining 2HDM by Present and Future Muon(g-2) Data

Constraints on the general 2HDM ("Model II") are obtained from the existing $(g-2)_{\mu}$ data including limits on Higgs bosons masses from LEP I data. We consider separately two cases: with a light scalar $h$ and with a light pseudoscalar $A$, assuming ${M_{h}+M_{A}} \ge {M_{Z}}$. The charged Higgs contribution is also included. It is found that already the present $(g-2)_{\mu}$ data improve limits obtained recently by ALEPH collaboration on \tb for the mass of the pseudoscalar below \mr 2 GeV. The improvement in the accuracy by factor 20 in the forthcoming E821 experiment may lead to more stringent, than provided by ALEPH group, limits up to $M_A\sim$ 30 GeV if the mass difference between $h$ and $A$ is $\sim M_Z$. Similar results should hold for a light scalar scenario as well.Comment: 19 pages, including 5 figure

Reperfusion Strategies and Outcomes of ST-Segment Elevation Myocardial Infarction Patients in Canada: Observations From the Global Registry of Acute Coronary Events (GRACE) and the Canadian Registry of Acute Coronary Events (CANRACE)

BACKGROUND: We examine the clinical characteristics and outcomes of ST-elevation myocardial infarction (STEMI) patients receiving various reperfusion therapies in 2 contemporary Canadian registries. METHODS: Of 4045 STEMI patients, 2024 received reperfusion therapy and had complete data on invasive management. They were stratified by reperfusion strategy used: primary percutaneous coronary intervention (PCI) (n =716); fibrinolysis with rescue PCI (n =177); fibrinolysis with urgent/elective PCI (n =210); and fibrinolysis without PCI (n =921). Data were collected on clinical and laboratory findings, and outcomes. RESULTS: Compared with fibrinolytic-treated patients, patients treated with primary PCI were younger and had higher Killip class, had longer time to delivery of reperfusion therapy, and utilized more antiplatelet therapy but less heparin, beta-blockers and angiotensin-converting enzyme inhibitors. In-hospital death occurred in 2.7% of patients treated with primary PCI, 1.7% fibrinolysis-rescue PCI, 1.0% fibrinolysis-urgent/elective PCI, and 4.8% fibrinolysis-alone (P =0.009); the rates of death/reinfarction were 3.9%, 4.0%, 4.3%, and 7.1% (P =0.032), respectively. The rate of shock was highest in the primary PCI group. Rates of heart failure or major bleeding were similar in the 4 groups. In multivariable analysis, no PCI during hospitalization was associated with death and reinfarction (adjusted odds ratio = 1.66; 95% confidence interval, 1.03-2.70; P =0.04). CONCLUSIONS: Clinical features, time to reperfusion, and medication utilization differed with respect to the reperfusion strategy. While low rates of re-infarction/death were observed, these complications occurred more frequently in those who did not undergo PCI during index hospitalization. Inc. All rights reserved