Search for baryon resonances up to 10 GeV mass produced in p+p->+mm with a resolution of +- 25 MeV

A simple magnet-less missiong-mass experiment is proposed to investigate the mass-spectrum of non-strange baryons of isospins 1/2 and 3/2 in the mass-range from 4 to 10GeV with a resolution of {+-}25 MeV or better. The spacing between baryons expected from the empirical interval rule {Delta}M{sup 2} = 1 BeV{sup 2} is 125 and 50 MeV for masses of 4 and 10 GeV respectively; if the rule holds, one expects 10{sup 2}-4{sup 2} = 84 resonances in this range. They plan to use the reaction p + p - p + MM and to detect the recoil protons in the region of the Jacobian peak. The protons of momenta from 400 to 850 MeV/c are selected by means of time-of-flight, range, and pulse height and are recorded in a pulse height analyzer. Since no magnets, wire planes, computers or any other major facilities are needed, the experiment can be done as soon as the beam, either full extracted (Option 1) or secondary diffracted (Option 2) or interla (Option 3) is available

Interview of George Cvijanovich by Laura J. Kissel

Charles Towns, pp.2 Admiral Thomas, pp. 3 Captain Smith, pp. 7, 18-19, 21 Mr. Audeshaw, pp. 12 Mr. Untersteiner, pp. 13, 17-18 Professor Glazer, pp. 15 CIA Director Helms, pp. 21 Ed Sullivan, pp. 22 Hugh Downs, pp. 22 Dorothy Kilgallen, pp. 22 Dave Garraway, pp. 22 Alex Cvijanovich, pp. 23Dr. Cvijanovich moved from geophysics at the Saharian Research Center to chief scientist at the USA North Pole Expedition Project “Ice Skate”. At Columbia University he developed a nuclear magnetic resonance detector for measuring the magnetic field of the Earth. He was asked to take over Station Alpha on the ice floe “Ice Skate”. He describes some of the challenges on the floe and on leaving the floe. The scientists took many cores. One had alternate layers of pink and gray mud. He describes the testing of the NMR instrument before taking it to the Arctic. After returning to Switzerland, he had the first experiment run on the high energy accelerator at Geneva. He returned to the U.S. and held positions at different universities. His experiences in the Arctic were retold on numerous radio shows. Cvijanovich briefly describes seeing a “yellow cloud” while in the Arctic. Major Topics Cvijanovich’s work at the Sorbonne and Columbia University Experiences on the ice floe “Ice Skate” Interaction between military personnel and scientists Development of a nuclear magnetic resonance instrument First experiment on the high energy accelerator at GenevaFunded by a grant from the National Science Foundation

Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

BackgroundPaediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS.MethodsIn this international, prospective, cross-sectional, observational study, 145 paediatric intensive care units (PICUs) from 27 countries were recruited, and over a continuous 5 day period across 10 weeks all patients were screened for enrolment. Patients were included if they had a new diagnosis of PARDS that met PALICC criteria during the study week. Exclusion criteria included meeting PARDS criteria more than 24 h before screening, cyanotic heart disease, active perinatal lung disease, and preparation or recovery from a cardiac intervention. Data were collected on the PICU characteristics, patient demographics, and elements of PARDS (ie, PARDS risk factors, hypoxaemia severity metrics, type of ventilation), comorbidities, chest imaging, arterial blood gas measurements, and pulse oximetry. The primary outcome was PICU mortality. Secondary outcomes included 90 day mortality, duration of invasive mechanical and non-invasive ventilation, and cause of death.FindingsBetween May 9, 2016, and June 16, 2017, during the 10 study weeks, 23 280 patients were admitted to participating PICUs, of whom 744 (3·2%) were identified as having PARDS. 95% (708 of 744) of patients had complete data for analysis, with 17% (121 of 708; 95% CI 14-20) mortality, whereas only 32% (230 of 708) of patients met Berlin criteria with 27% (61 of 230) mortality. Based on hypoxaemia severity at PARDS diagnosis, mortality was similar among those who were non-invasively ventilated and with mild or moderate PARDS (10-15%), but higher for those with severe PARDS (33% [54 of 165; 95% CI 26-41]). 50% (80 of 160) of non-invasively ventilated patients with PARDS were subsequently intubated, with 25% (20 of 80; 95% CI 16-36) mortality. By use of PALICC PARDS definition, severity of PARDS at 6 h after initial diagnosis (area under the curve [AUC] 0·69, 95% CI 0·62-0·76) discriminates PICU mortality better than severity at PARDS diagnosis (AUC 0·64, 0·58-0·71), and outperforms Berlin severity groups at 6 h (0·64, 0·58-0·70; p=0·01).InterpretationThe PALICC definition identified more children as having PARDS than the Berlin definition, and PALICC PARDS severity groupings improved the stratification of mortality risk, particularly when applied 6 h after PARDS diagnosis. The PALICC PARDS framework should be considered for use in future epidemiological and therapeutic research among children with PARDS.FundingUniversity of Southern California Clinical Translational Science Institute, Sainte Justine Children's Hospital, University of Montreal, Canada, Réseau en Santé Respiratoire du Fonds de Recherche Quebec-Santé, and Children's Hospital Los Angeles, Department of Anesthesiology and Critical Care Medicine