Science and Technology in Elijah Muhammad’s Nation of Islam

This article explores the centrality of science and technology to religious thought and practice in Elijah Muhammad’s Nation of Islam from the 1950s through the 1970s. Tracing the dynamic meanings of scientific knowledge in the context of the postwar United States, the article’s central argument is that like other UFO and extraterrestrial religions, the Nation of Islam emphasized scientific, material, and empirical over spiritual and supernatural understandings of religion. It also suggests how members of this new religious movement studied and attempted to live according to the scientific and mathematical principles derived from their prophet’s cosmological, ontological, and eschatological teachings on the nature of God, the origins and destiny of the black race, and the beginning and end of white supremacy

Transnational Muslim Americans: Four Women in Jordan

This article examines the biographies of four Muslim American women who have lived in Amman, Jordan. It seeks to understand how residency in this Muslim-majority country in the Middle East has affected their religious attitudes and practices as well as their gender, ethnic, and national identities. In offering analysis of these women’s own thinking about how their time in Jordan hador had not altered their Muslim and American identities and practices, this article contributes to larger scholarly conversations about religion and politics in transnational perspective. The travel and observations of these four women in Amman evidenced the often unpredictable nature of personal change when a human being moves, both physically and spiritually, from one place to another. Their stories confirm that the focus of much social scientific literature on transnationalism on how institutions—both formal and informal, state and non-state--delimit, constrain, and shape political identity is useful and necessary in understanding transnational ventures. But it also shows that such literature does not always account for the possible religious meanings of human movement. The transnational Muslim Americans in this study engage in ethical and cosmic, national and transnational practices all at once. Their stories show how an account sensitive to religious activity can helpfully account for the multiple meanings of transnational practice among Muslim Americans

Investigation of the Feasibility of Using the Back-pack Blower for Timber Stand Improvement in Eastern Oklahoma

Technical Educatio

The Transnational and Diasporic Future of African American Religions in the United States

This article calls forth a vision for the future study of African American religions in the United States by examining how transnational contact and diasporic consciousness have affected the past practice and are likely to affect the future practice of Christianity, Islam, and African-derived, Orisha-based religions in Black America. It offers a synthesis of scholarly literature and charts possible directions for analyzing Africana religions beyond the ideological and geographical boundaries of the nation-state. The article focuses on two primary forms of imagined and physical movement: the immigration of self-identifying Black people from Africa, Europe, the Caribbean, Mexico, and other places to the United States; and the travel, tourism, pilgrimage, and other movement—whether physical or not—of American-born Black people to places outside the Unites States

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas

FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to pathologies associated with paradoxical ERK1/2 activation in wild-type BRAF cells. To overcome this limitation, a next-generation paradox-breaking RAF inhibitor (PLX8394) has been designed. Here, we show that by using a quantitative reporter assay, PLX8394 rapidly suppressed ERK1/2 reporter activity and growth of mutant BRAF melanoma xenografts. Ex vivo treatment of xenografts and use of a patient-derived explant system (PDeX) revealed that PLX8394 suppressed ERK1/2 signaling and elicited apoptosis more effectively than the FDA-approved BRAF inhibitor, vemurafenib. Furthermore, PLX8394 was efficacious against vemurafenibresistant BRAF splice variant-expressing tumors and reduced splice variant homodimerization. Importantly, PLX8394 did not induce paradoxical activation of ERK1/2 in wild-type BRAF cell lines or PDeX. Continued in vivo dosing of xenografts with PLX8394 led to the development of acquired resistance via ERK1/2 reactivation through heterogeneous mechanisms; however, resistant cells were found to have differential sensitivity to ERK1/2 inhibitor. These findings highlight the efficacy of a paradox-breaking selective BRAF inhibitor and the use of PDeX system to test the efficacy of therapeutic agents. © 2017 American Association for Cancer Research

Engineering Proteinase Inihibitor Genes For Plant Defense Against Predators

Small proteinaceous inhibitors (Mr\u3c20,000) of the digestive serine proteinases of animals and microorganisms are found as moderately abundant proteins in storage organs and leaves of many plant genera. The proteins are powerful inhibitors of the digestive enzymes of plant predators and therefore are considered to be part of the array of defensive chemicals of plants. Proteinase inhibitor genes show excellent promise, using DNA technology, to manipulate plant genomes to express these biologically active proteins in order to improve natural defense systems. Members of two unrelated families of serine proteinase inhibitors found in tomato and potato plants, called Inhibitor I (monomer Mr 8000) and Inhibitor II (monomer Mr 12,300), are under both environmental and developmental regulation in different tissues of the plants. Genes coding for wound-inducible Inhibitors I and II have been isolated from both tomato and potato genomes and characterized. Tobacco plants have been transformed with the chimeric genes containing wound-inducible promoters fused with the reporter gene, chloramphenicol acetyl transferase, to assess promoter function and signal transmission. Transacting factors that regulate their expression in response to wounding are also being identified and purified. Intact genes are being employed to transform agriculturally important crop plants to determine their potential usefulness to enhance defensive capabilities of plants against herbivores and pathogens

High-resolution SOFIA/EXES Spectroscopy of Water Absorption Lines in the Massive Young Binary W3 IRS 5

We present in this paper mid-infrared (5-8~$\mu$m) spectroscopy toward the massive young binary W3~IRS~5, using the EXES spectrometer in high-resolution mode ($R\sim$50,000) from the NASA Stratospheric Observatory for Infrared Astronomy (SOFIA). Many ($\sim$180) $\nu_2$=1--0 and ($\sim$90) $\nu_2$=2-1 absorption rovibrational transitions are identified. Two hot components over 500 K and one warm component of 190 K are identified through Gaussian fittings and rotation diagram analysis. Each component is linked to a CO component identified in the IRTF/iSHELL observations ($R$=88,100) through their kinematic and temperature characteristics. Revealed by the large scatter in the rotation diagram, opacity effects are important, and we adopt two curve-of-growth analyses, resulting in column densities of $\sim10^{19}$ cm$^{-2}$. In one analysis, the model assumes a foreground slab. The other assumes a circumstellar disk with an outward-decreasing temperature in the vertical direction. The disk model is favored because fewer geometry constraints are needed, although this model faces challenges as the internal heating source is unknown. We discuss the chemical abundances along the line of sight based on the CO-to-H$_2$O connection. In the hot gas, all oxygen not locked in CO resides in water. In the cold gas, we observe a substantial shortfall of oxygen and suggest that the potential carrier could be organics in solid ice.Comment: Accepted for publication in ApJ. 34 pages, 13 figures, and 14 tables. Comments are more than welcome

Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.

Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat metastatic breast cancer, we performed metabolomics profiling on the breast cancer cell line MDA-MB-231 and its tissue-tropic metastatic subclones. Here, we report that these subclones with increased metastatic potential display an altered metabolic profile compared with the parental population. In particular, the mitochondrial serine and one-carbon (1C) unit pathway is upregulated in metastatic subclones. Mechanistically, the mitochondrial serine and 1C unit pathway drives the faster proliferation of subclones through enhanced de novo purine biosynthesis. Inhibition of the first rate-limiting enzyme of the mitochondrial serine and 1C unit pathway, serine hydroxymethyltransferase (SHMT2), potently suppresses proliferation of metastatic subclones in culture and impairs growth of lung metastatic subclones at both primary and metastatic sites in mice. Some human breast cancers exhibit a significant association between the expression of genes in the mitochondrial serine and 1C unit pathway with disease outcome and higher expression of SHMT2 in metastatic tumor tissue compared with primary tumors. In addition to breast cancer, a few other cancer types, such as adrenocortical carcinoma and kidney chromophobe cell carcinoma, also display increased SHMT2 expression during disease progression. Together, these results suggest that mitochondrial serine and 1C unit metabolism plays an important role in promoting cancer progression, particularly in late-stage cancer. IMPLICATIONS: This study identifies mitochondrial serine and 1C unit metabolism as an important pathway during the progression of a subset of human breast cancers