Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. To date, there are no significant disease-modifying treatments, and one limiting factor in treatment is the amount of time it takes for a patient to receive a diagnosis of ALS. This study examined multiple mouse models before symptom onset to help identify early changes in a reflex circuit of ALS mice. Dorsal root stimulation of the sacral spinal cord in multiple models ALS mouse models showed changes in the resulting ventral root compound action potential amplitude, latency, and ability to maintain synaptic depression. These data also suggest that a mouse model of TDP43 inclusions is fundamentally different in its network properties than that of SOD1 ALS mutant mice. While these data suggest changes in motor neuron excitability may play a contributing factor, there are likely other synaptic changes involved, but further work needs to be done to verify this

PERSPECTIVES Development of interventions for language impairment: Why universal grammar may be harmful (Commentary on Ambridge, Pine, and Lieven)

Although theories of specific language impairment grounded in universal grammar (UG ) have advanced the description of SLI considerably, they provide limited utility as far as treatment is concerned. Because UG assumes deficits in language principles and parameter setting, remediation of the difficulty is not possible; rather, reliance on compensatory mechanisms is recommended. Compensatory mechanisms rely on the same learning principles as are adopted by theorists that adopt a more emergentist view. Thus, we agree with Ambridge, Pine, and Lieven that a UG-based approach is redundant and recommend focusing efforts on identifying and strengthening treatment strategies associated with general learning principles instead

Classification Accuracy of the Quick Interactive Language Screener for Preschool Children with and without Developmental Language Disorder

This research examined the classification accuracy of the Quick Interactive Language Screener (QUILS) for identifying preschool-aged children (3;0 to 6;9) with developmental language disorder (DLD). We present data from two independent samples that varied in prevalence and diagnostic reference standard

Crowdsourcing hypothesis tests: Making transparent how design choices shape research results

To what extent are research results influenced by subjective decisions that scientists make as they design studies? Fifteen research teams independently designed studies to answer fiveoriginal research questions related to moral judgments, negotiations, and implicit cognition. Participants from two separate large samples (total N > 15,000) were then randomly assigned to complete one version of each study. Effect sizes varied dramatically across different sets of materials designed to test the same hypothesis: materials from different teams renderedstatistically significant effects in opposite directions for four out of five hypotheses, with the narrowest range in estimates being d = -0.37 to +0.26. Meta-analysis and a Bayesian perspective on the results revealed overall support for two hypotheses, and a lack of support for three hypotheses. Overall, practically none of the variability in effect sizes was attributable to the skill of the research team in designing materials, while considerable variability was attributable to the hypothesis being tested. In a forecasting survey, predictions of other scientists were significantly correlated with study results, both across and within hypotheses. Crowdsourced testing of research hypotheses helps reveal the true consistency of empirical support for a scientific claim.</div

The 2009 december gamma-ray flare of 3C 454.3: The multifrequency campaign

During the month of 2009 December, the blazar 3C 454.3 became the brightest gamma-ray source in the sky, reaching a peak flux F 2000 × 10 -8 photons cm-2 s-1 for E > 100 MeV. Starting in 2009 November intensive multifrequency campaigns monitored the 3C 454 gamma-ray outburst. Here, we report on the results of a two-month campaign involving AGILE, INTEGRAL, Swift/XRT, Swift/BAT, and Rossi XTE for the high-energy observations and Swift/UVOT, KANATA, Goddard Robotic Telescope, and REM for the near-IR/optical/UV data. GASP/WEBT provided radio and additional optical data. We detected a long-term active emission phase lasting 1 month at all wavelengths: in the gamma-ray band, peak emission was reached on 2009 December 2-3. Remarkably, this gamma-ray super-flare was not accompanied by correspondingly intense emission in the optical/UV band that reached a level substantially lower than the previous observations in 2007-2008. The lack of strong simultaneous optical brightening during the super-flare and the determination of the broadband spectral evolution severely constrain the theoretical modeling. We find that the pre- and post-flare broadband behavior can be explained by a one-zone model involving synchrotron self-Compton plus external Compton emission from an accretion disk and a broad-line region. However, the spectra of the 2009 December 2-3 super-flare and of the secondary peak emission on 2009 December 9 cannot be satisfactorily modeled by a simple one-zone model. An additional particle component is most likely active during these states. © 2010. The American Astronomical Society. All rights reserved

Review of population health research and health services research in Ireland.

The Health Research Board (HRB) today launched its ‘Review of population health research and health services research in Ireland’. The review, informed by the thinking of leading experts, provides clear evidence on the greater role for research in improving the health of the Irish population and the manner in which the Irish health care system functions. It hopes to drive change by grounding concepts in the reality of data, explaining as well as describing the challenges and opportunities that we must all address in the coming years

A missing voice in the discourse of evidence-based practice

The purpose of this investigation was to examine the discourse of evidence-based practice presented in official written documents of the American Speech-Language-Hearing Association. Documents were analyzed with respect to how language was used to convey a sense of certainty about the profession\u27s official position on evidence-based practice, what should count as evidence, and how the role of the client was constructed. Analysis revealed a missing voice-or verbal/ideological perspective (M. M. Bahktin, trans. 1981)-in the construction of evidence. This voice is characterized by observations from the lives of clients and their expressed experiences with assessment and intervention, a form of evidence whose units of analysis do not readily meet the constraints of objectivity and quantification grounded in an epistemology of traditional experimental research methods. Among other things, it will be argued that the current official version of evidence-based practice needs to be reconstructed to include the voices of clients as a form of evidence. Copyright © 2007 Wolters Kluwer Health | Lippincott Williams & Wilkins

Laughter and communicative engagement in interaction

We examined if and how laughter functioned communicatively as an indicator of engagement in group interactions involving adults with traumatic brain injury (TBI). Engagement refers to the intensity and manner of interpersonal involvement displayed by participants in social situations, and it reflects the extent to which they are mutually engrossed in, and alive to, the unfolding interaction. Analysis revealed that laughter functioned communicatively to support the face, or public self-image, of those with TBI and to foster rapport and social closeness. The distribution of laughables, or verbal and nonverbal behaviors that occasion laughter, between participants was also examined and compared with data collected by Simmons-Mackie and Schultz in their analysis of humor during traditional aphasia therapy. Results revealed that laughter and laughables are sensitive to how individuals engage one another in interaction. Implications are considered with respect to more recent models of intervention that seek to promote more discourse equality between participants. Copyright © 2009 by Thieme Medical Publishers, Inc

Less is more: Implementing the ‘Minimal Intervention Needed for Change (MINC)’ approach to increase contextual fit of speech-language interventions

Abstract Purpose: Speech-Language Pathologists (SLPs) and researchers face difficulties in moving evidence-based practices from clinical research into widespread practice, in part due to a mismatch between the design of typical intervention research studies and the realities of clinical settings. SLPs must adapt interventions from the literature or established programs to fit the needs of specific clients and settings. Researchers must design studies that better reflect clinical practice. Method: Here, we provide an overview of the Minimal Intervention Needed for Change (MINC) approach; a systematic approach to developing and adapting interventions that focuses on achieving meaningful outcomes within specific contexts. We outline the principles of MINC, and illustrate this process through use of a case study. Results: MINC can support systematic development and adaptation of interventions in clinical and research settings, particularly settings with resource limitations. Conclusions: Researchers should work to align research intervention work with typical clinical settings. This involves both targeting outcomes that are functional and clinically significant and acknowledging resource limitations. SLPs should adapt evidence-based interventions systematically and carefully to meet the needs of clients and settings while retaining the core components of intervention that result in meaningful change for clients