3,733 research outputs found
Redesigning the Walker: A More Durable & Dignified Device
Aging and Rehabilitation Engineering is a prominent field with ample room for development of and improvement upon existing options. Surveying city sidewalks, family gatherings, hospital waiting rooms it becomes apparent that the need for mobility aids is abundant. My proposal for Capstone is to redesign the walker from both my mechanical engineering and sculptural perspectives. A walker is meant to improve the quality of life for those who are unable to walk unassisted, but should not come at the cost of the user’s dignity. The way we carry ourselves says a lot about us (i.e. character, will, and level of care for our bodies). I want to further improve quality of life by elevating the walker to a dignified piece of equipment. I propose to focus on ease of use, opportunity for customization (for those individuals with specific needs in addition to stability while walking), and improving the aesthetics of this important device that serves as a daily presence in many people’s lives
Resonant plasma excitation by single-cycle THz pulses
In this paper, an alternative perspective for the generation of millimetric high-gradient resonant plasma waves is discussed. This method is based on the plasma-wave excitation by energetic single-cycle
THz pulses whose temporal length is comparable to the plasma wavelength. The excitation regime discussed in this paper is the quasi-nonlinear regime that can be achieved when the normalized vector potential of the driving THz pulse is on the order of unity. To investigate this regime and determine the strength of the excited electric elds, a Particle-In-Cell (PIC) code has been used. It has been found that by exploiting THz pulses with characteristics currently available in laboratory, longitudinal electron plasma waves with electric gradients up to hundreds MV/m can be obtained. The mm-size nature of
the resonant plasma wave can be of great utility for an acceleration scheme in which high-brightness electron bunches are injected into the wave to undergo a strong acceleration. The long-size nature of the acceleration bucket with respect to the short length of the electron bunches can be handled in a more robust manner in comparison with the case when micrometric waves are employed
Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway
Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) or 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively. Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research
Effect of Ferric Sodium EDTA administration, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine, on cardiovascular risk evaluation: exploration of the HRV frequency domain
diseases. Using the Heart Rate Variability (HRV) analysis is possible to provide an evaluation of the safety and the
effectiveness of intervention.
Objective: To evaluate the efficacy and safety of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper
gluconate, zinc gluconate and selenomethionine (Ferachel forte®) 2 tabs/day for 24 days in elderly patients with secondary
anaemia, by exploring the HRV frequency domain.
Methods: In 45 elderly patients with secondary anaemia and/or low-moderate kidney failure, laboratory values after
administration of Ferric Sodium EDTA, 2 tabs a day, in combination with vitamin C, folic acid, copper gluconate, zinc
gluconate and selenomethionine (Ferachel forte®) for 24 days (N=16 patients) or ferrous gluconate 63 mg/day added to
saline solution, administered using intravenous access during the hospitalization period of 15 ± 5 days (N=29 patients)
were evaluated. Also, ECG signals and bioelectrical impedance (BIA) were measured.
Results: Oral iron supplementation with Ferric Sodium EDTA, in combination with vitamin C, folic acid, copper gluconate,
zinc gluconate and selenomethionine (Ferachel forte®) confirmed to be effective and safe about the cardiovascular risk
in old patients. This study showed the real superiority of the oral administration about the cardiovascular risk in elderly
patients in comparison with intravenous administration of ferrous gluconate.
Conclusion: This study confirms that Ferric Sodium EDTA combination (Ferachel forte®) can be a valid alternative to ferrous
gluconate intravenous therapy (gold standard) in the treatment of secondary anaemia in elderly patients. In fact, during
the treatment, efficacy results have been maintained without statistically significant variations about cardiovascular risk,
evaluated by exploring the HRV frequency domain
5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted. Here, we evaluated in vitro the antiproliferative activity of some 5-(carbamoylmethylene)-oxazolidin-2-ones on MCF-7 and HeLa cells. The tested compounds displayed a wide range of cytotoxicity on these cancer cell lines, measured by MTT assay, exhibiting no cytotoxicity on non-tumorigenic MCF-10A cells. Among the nine tested derivatives, four displayed a good anticancer potential. Remarkably, OI compound showed IC50 values of 17.66 and 31.10 µM for MCF-7 and HeLa cancer cells, respectively. Furthermore, we assessed OI effect on the cell cycle by FACS analysis, highlighting a G1 phase arrest after 72 h, supported by a low expression level of Cyclin D1 protein. Moreover, mitochondrial membrane potential was reduced after OI treatment driven by high levels of ROS. These findings demonstrate that OI treatment can inhibit MCF-7 and HeLa cell proliferation and induce apoptosis by caspase-9 activation and cytochrome c release in the cytosol. Hence, 5-(carbamoylmethylene)-oxazolidin-2-ones have a promising anticancer activity, in particular, OI derivative could represent a good candidate for in vivo further studies and potential clinical use
Trends of Aboveground Net Primary Productivity of Patagonian Meadows, the Omitted Ecosystem in Desertification Studies
The United Nations defines desertification as the loss of productivity in arid and semiarid environments. The extended steppes of Patagonia harbor small meadows whose compounded area is comparatively small, but their aboveground net primary production (ANPP) is up to ten times higher than their surroundings. These meadows then represent a key ecosystem for cattle grazing systems, but there are no descriptions of the trends in their ANPP and, consequently, their carrying capacity, and, as a result, their degradation syndromes. Our objectives were as follows: (1) analyze the trends of mean and spatial heterogeneity of annual ANPP in meadows and neighboring steppes and relate them with precipitation and temperature, (2) evaluate the impact on the livestock carrying capacity of meadows in the region, and (3) evaluate the degradation trends of these meadows, based on a novel description proposed to characterize the trend syndromes of these type of ecosystems. We identified
meadow areas across a subcontinental scale in Patagonia, covering a mean annual precipitation range from 129 to 936 mm. We estimated ANPP on a monthly basis from 2000 to 2019 via regional calibrated remote sensing information. In the last two decades, ANPP decreased in 74% of the studied meadow
areas, while remaining relatively stable in the nearby steppes. This decrease was relatively higher in the arid end of the analyzed precipitation gradient. Hence, the global carrying capacity for all the studied meadow areas decreased by 8%. Finally, we identified four trend syndromes based on
the combination of the ANPP trend and its spatial heterogeneity, calculated as the spatial standard deviation. The predominant trend syndrome, in 55% of the area, was associated with a negative trend of both ANPP and spatial heterogeneity. These results could help prioritize areas where specific management decisions, given the different trend syndromes, could help revert ANPP negative trends
Caracterizacao de tres diferentes ambientes edaficos e sua influencia sobre o peso de folhas de Maytenus ilicifolia (Espinheira-Santa), especie medicinal nativa da regiao sul do Brasil.
Este trabalho e parte de um estudo sobre a influencia de diferentes ambientes no desenvolvimento e na composicao quimica de Maytenus ilicifolia (Espinheira-santa), especie medicinal nativa da regiao Sul do Brasil. Sua distribuicao atual esta restrita as areas de mata ciliar, ou aos solos inaptos para a agricultura intensiva, ocupando geralmente os estratos inferiores das formacoes vegetais. Apos comprovacao das suas proriedades medicinais, as coletas tem se intensificado atraves do extrativismo predatorio, colocando em risco os germoplasmas existentes. Devido a escassez de informacoes sobre a auto-ecologia da especie, as recomendacoes de manejo das areas nativas ou de cultivos tornam-se limitadas. Neste sentido, foram caracterizados alguns ambientes de ocorrencia natural da espinheira-santa, em are localizada no municipio da Lapa-PR (entre 25 graus e 42' e 35 graus e 45' S, e 49 graus e 34' e 49 graus e 36' L e 970 m a.n.m.), coberta originalmente pela Floresta Ombrofila Mista, selecionando-se uma toposequencia com as seguintes classes de solo:..
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