ORYA: A Strategy Oriented Deployment Framework

International audienceThe current trend consists in deploying, on each machine, a specific version of an application, according to the choices of the enterprise and users, with constraints verified by the target site. To support automated deployment, we propose a model-based deployment framework named ORYA which allows to define and execute deployment strategies. This paper presents and illustrates the concept of deployment strategy supported by the framework

Recent Increase in Meningitis Caused by Neisseria meningitidis Serogroups A and W135, Yaoundé, Cameroon

From 1991 to 1998, Neisseria meningitidis serogroups A, B, and C represented 2%-10% of strains isolated from cases of bacterial meningitis in Yaoundé. During 1999 to 2000, the percentage of meningococci reached 17%, a proportion never reported since recordkeeping began in 1984. The increase of serogroup A meningococci and the emergence of W135 strains highlight the need for increased surveillance for better diagnosis and prevention

The use of Natural Language Processing as a tool to help exploit hospital data

peer reviewedLe CHU de Liège dispose d’un Dossier Médical Informatisé dans lequel coexistent des données structurées et non structurées. Depuis plus de 10 ans, il a aussi développé un large entrepôt de données clinques compilant l’ensemble de l’information clinique et paraclinique de l’institution. De plus, une équipe d’analystes est devenue experte de l’exploitation des données, essentiellement des données structurées. La question qui se pose actuellement est de savoir comment tirer et exploiter la richesse de toute l’information contenue dans les données non structurées du Dossier Patient Informatisé. Plus particulièrement, les nouvelles technologies de traitement du langage naturel (NLP Natural Langage Processing) apportent-elles une plus-value significative dans l’exploitation des données médicales

Développement d’un outil de pilotage des patients oncologiques au CHU de Liège

peer reviewedLe nombre de cas de cancer est en augmentation constante, en Belgique comme partout dans le monde. Plusieurs services du CHU de Liège se sont regroupés au sein d’un Institut de Cancérologie, afin d’assurer une gestion intégrée multidisciplinaire de cette masse de patients. Cet article présente comment les données de l’entrepôt de données cliniques institutionnel ont été exploitées afin de développer un outil de pilotage transversal de l’activité des patients oncologiques

Inhibition of Inflammatory Arthritis Using Fullerene Nanomaterials

Inflammatory arthritis (e.g. rheumatoid arthritis; RA) is a complex disease driven by the interplay of multiple cellular lineages. Fullerene derivatives have previously been shown to have anti-inflammatory capabilities mediated, in part, by their ability to prevent inflammatory mediator release by mast cells (MC). Recognizing that MC can serve as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis, it was hypothesized that fullerene derivatives might be used to target this inflammatory disease. A panel of fullerene derivatives was tested for their ability to affect the function of human skin-derived MC as well as other lineages implicated in arthritis, synovial fibroblasts and osteoclasts. It is shown that certain fullerene derivatives blocked FcγR- and TNF-α-induced mediator release from MC; TNF-α-induced mediator release from RA synovial fibroblasts; and maturation of human osteoclasts. MC inhibition by fullerene derivatives was mediated through the reduction of mitochondrial membrane potential and FcγR-mediated increases in cellular reactive oxygen species and NF-κB activation. Based on these in vitro data, two fullerene derivatives (ALM and TGA) were selected for in vivo studies using K/BxN serum transfer arthritis in C57BL/6 mice and collagen-induced arthritis (CIA) in DBA/1 mice. Dye-conjugated fullerenes confirmed localization to affected joints in arthritic animals but not in healthy controls. In the K/BxN moldel, fullerenes attenuated arthritis, an effect accompanied by reduced histologic inflammation, cartilage/bone erosion, and serum levels of TNF-α. Fullerenes remained capable of attenuating K/BxN arthritis in mast cell-deficient mice Cre-Master mice, suggesting that lineages beyond the MC represent relevant targets in this system. These studies suggest that fullerene derivatives may hold promise both as an assessment tool and as anti-inflammatory therapy of arthritis

Clusterine (une nouvelle opsonine qui favorise la clairance des cellules apoptotiques et protège de la réponse auto-immune induite par un excès de cellules apoptotiques)

ANGERS-BU Médecine-Pharmacie (490072105) / SudocSudocFranceF

L’esclavage en Afrique : histoires, héritages et actualités

Rapport Annuel IRD 2014, p. 3

Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction

Histology of bone marrow routinely identifies megakaryocytes that enclose neutrophils and other hematopoietic cells, a phenomenon termed emperipolesis. Preserved across mammalian species and enhanced with systemic inflammation and platelet demand, the nature and significance of emperipolesis remain largely unexplored. Recent advances demonstrate that emperipolesis is in fact a distinct form of cell-in-cell interaction. Following integrin-mediated attachment, megakaryocytes and neutrophils both actively drive entry via cytoskeletal rearrangement. Neutrophils enter a vacuole termed the emperisome which then releases them directly into the megakaryocyte cytoplasm. From this surprising location, neutrophils fuse with the demarcation membrane system to pass membrane to circulating platelets, enhancing the efficiency of thrombocytogenesis. Neutrophils then egress intact, carrying megakaryocyte membrane and potentially other cell components along with them. In this review, we summarize what is known about this intriguing cell-in-cell interaction and discuss potential roles for emperipolesis in megakaryocyte, platelet and neutrophil biology

Evolution Handling in PSEEs

The move to more mature software development processes (in the sense of the CMM approach [1]) implies a significant emphasis on process evolution. Currently, Process-centred Software Engineering Environments (PSEEs) are providing means to define and enact process models. However, consistent process and process model evolution still presents considerable difficulties. A major reason is the commonplace deviation between the enactment of a process model and the corresponding activities (process performance) taking place in the real world. In this paper, we analyse the evolution problem and we identify the core requirements for an enhanced PSEE architecture for evolution handling. Then we propose a generic PSEE architecture for consistent process and process model evolution and we describe the experimentation of our theoretical results, done using the Process Weaver system [2]. Keywords: process modelling, process evolution, meta-process, consistency management, architecture for process-c..