Mechanism of Future Spring Drying in the Southwest U.S. in CMIP5 Models

The net surface water budget, precipitation minus evaporation (P-E), shows a clear seasonal cycle in the American Southwest with net gain of surface water (positive P-E) in the cold half of the year (October to March) and net loss of water (negative P-E) in the warm half (April – September), with June and July being the driest months of the year. There is a significant shift of the summer drying toward earlier in the year under a CO2 warming scenario, resulting in substantial spring drying (MAM) of the American Southwest, from the near-term future to the end of the current Century with gradually increasing magnitude. While the spring drying has been identified in previous studies, its mechanism has not been fully addressed. Using moisture budget analysis, we found that the drying is mainly due to decreased mean moisture convergence, partially compensated by the increase in transient eddy moisture flux convergence. The decreased mean moisture convergence is further separated into components due to changes in circulation (dynamic changes) and changes in atmospheric moisture content (thermodynamic changes). The drying is found to be dominated by the thermodynamic driven changes in column averaged moisture convergence, due mainly to increased dry zonal advection caused by the climatological land-ocean thermal contrast, rather than by the well-known “dry get drier” mechanism. Furthermore, the enhanced dry advection in the warming climate is dominated by the robust zonal mean atmospheric warming, leading to equally robust spring drying in Southwest US

Calculation of oxygen diffusion coefficients in oxide films formed on low-temperature annealed Zr alloys and their related corrosion behavior

The growth of oxide film, which results from the inward oxygen diffusion from a corrosive environment, is a critical consideration for the corrosion resistance of zirconium alloys. This work calculates the oxygen diffusion coefficients in the oxide films formed on zirconium alloys annealed at 400~500 °C and investigates the related corrosion behavior. The annealed samples have a close size for the second-phase particles but a distinctive hardness, indicating the difference in substrate conditions. The weight gain of all samples highly follows parabolic laws. The weight gain of the sample annealed at 400 °C has the fastest increase rate at the very beginning of the corrosion test, but its oxide film has the slowest growth rate as the corrosion proceeds. By contrast, the sample annealed at 500 °C shows the lowest weight gain but the highest corrosion rate constant. Such a corrosion behavior is attributed to the amount of defects existing in the oxide film formed on the annealed samples; fewer defects would provide a lower fraction of short-circuit diffusion in total diffusion, resulting in a lower diffusion coefficient of oxygen in the oxide film, thereby producing better corrosion resistance. This is consistent with the calculated diffusion coefficients of oxygen in the oxide films: 3.252 × 10−11 cm2/s, 3.464 × 10−11 cm2/s and 3.740 × 10−11 cm2/s for the samples annealed at 400 °C, 450 °C, and 500 °C, respectively

Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells

A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive agents, especially natural ingredients that may provide sufficient efficacy in immunosuppression with minimal side effects. Shikonin is a bioactive naphthoquinone pigment, an ingredient originally extracted from the root of Lithospermum erythrorhizon. Previous studies have shown that shikonin regulates immunity and exerts anti-inflammatory effects. In particular, it can ameliorate arthritis in animal models. However, it is unclear whether shikonin inhibits alloimmunity or allograft rejection. In this study and for the first time, we demonstrated that shikonin significantly prolonged the survival of skin allografts in wild-type mice. Shikonin increased the frequencies of CD4+Foxp3+ regulatory T cells (Tregs) post-transplantation and induced CD4+Foxp3+ Tregs in vitro as well. Importantly, depleting the Tregs abrogated the extension of skin allograft survival induced by shikonin. It also decreased the frequencies of CD8+CD44highCD62Llow effector T cells and CD11c+CD80+/CD11c+CD86+ mature DCs after transplantation. Moreover, we found that shikonin inhibited the proliferation of T cells in vitro and suppressed their mTOR signaling. It also reduced the gene expression of pro-inflammatory cytokines, including IFNγ, IL-6, TNFα, and IL-17A, while increasing the gene expression of anti-inflammatory mediators IL-10, TGF-β1, and indoleamine-2, 3-dioxygenase (IDO) in skin allografts. Further, shikonin downregulated IDO protein expression in skin allografts and DCs in vitro. Taken together, shikonin inhibits allograft rejection via upregulating CD4+Foxp3+ Tregs. Thus, shikonin is a novel immunosuppressant that could be potentially used in clinical transplantation

Ocean-forcing of cool season precipitation drives ongoing and future decadal drought in southwestern North America

The US Southwest is in a drought crisis that has been developing over the past two decades, contributing to marked increases in burned forest areas and unprecedented efforts to reduce water consumption. Climate change has contributed to this ongoing decadal drought via warming that has increased evaporative demand and reduced snowpack and streamflows. However, on the supply side, precipitation has been low during the 21st century. Here, using simulations with an atmosphere model forced by imposed sea surface temperatures, we show that the 21st century shift to cooler tropical Pacific sea surface temperatures forced a decline in cool season precipitation that in turn drove a decline in spring to summer soil moisture in the southwest. We then project the near-term future out to 2040, accounting for plausible and realistic natural decadal variability of the Pacific and Atlantic Oceans and radiatively-forced change. The future evolution of decadal variability in the Pacific and Atlantic will strongly influence how wet or dry the southwest is in coming decades as a result of the influence on cool season precipitation. The worst-case scenario involves a continued cold state of the tropical Pacific and the development of a warm state of the Atlantic while the best case scenario would be a transition to a warm state of the tropical Pacific and the development of a cold state of the Atlantic. Radiatively-forced cool season precipitation reduction is strongest if future forced SST change continues the observed pattern of no warming in the equatorial Pacific cold tongue. Although this is a weaker influence on summer soil moisture than natural decadal variability, no combination of natural decadal variability and forced change ensures a return to winter precipitation or summer soil moisture levels as high as those in the final two decades of the 20th century

Mechanisms of a Meteorological Drought Onset: Summer 2020 to Spring 2021 in Southwestern North America

By summer 2021 moderate to exceptional drought impacted 28% of North America, focused west of the Mississippi, with serious impacts on fire, water resources, and agriculture. Here, using reanalyses and SST-forced climate models, we examine the onset and development of this southwestern drought from its inception in summer 2020 through winter and spring 2020/21. The drought severity in summer 2021 resulted from four consecutive prior seasons in which pre- cipitation in the southwest United States was the lowest on record or, at least, extremely dry. The dry conditions in summer 2020 arose from internal atmospheric variability but are beyond the range of what the studied atmosphere models simulate for that season. From winter 2020 through spring 2021 the worsening drought conditions were guided by the development of a La Nina in the tropical Pacific Ocean. Decadal variability in the Pacific Ocean aided drought in the southern part of the region by driving the cool season to be drier during the last two decades. There is also evidence that the southern part of the region in spring is drying due to human-driven climate change. In sum the drought onset was driven by a combination of internal atmospheric variability and interannual climate variability and aided by natural decadal variability and human-driven climate change

Synergistic Effects of Chronic Restraint-Induced Stress and Low-Dose 56Fe-particle Irradiation on Induction of Chromosomal Aberrations in Trp53-Heterozygous Mice

Astronauts can develop psychological stress (PS) during space flights due to the enclosed environment, microgravity, altered light-dark cycles, and risks of equipment failure or fatal mishaps. At the same time, they are exposed to cosmic rays including high atomic number and energy (HZE) particles such as iron-56 (Fe) ions. Psychological stress or radiation exposure can cause detrimental effects in humans. An earlier published pioneering study showed that chronic restraint-induced psychological stress (CRIPS) could attenuate Trp53 functions and increase carcinogenesis induced by low-linear energy transfer (LET) γ rays in Trp53-heterozygous (Trp53+/–) mice. To elucidate possible modification effects from CRIPS on high-LET HZE particle-induced health consequences, Trp53+/– mice were received both CRIPS and accelerated Fe ion irradiation. Six-week-old Trp53+/– C57BL/6N male mice were restrained 6 h per day for 28 consecutive days. On day 8, they received total-body Fe-particle irradiation (Fe-TBI, 0.1 or 2 Gy). Metaphase chromosome spreads prepared from splenocytes at the end of the 28-day restraint regimen were painted with the fluorescence in situ hybridization (FISH) probes for chromosomes 1 (green), 2 (red) and 3 (yellow). Induction of psychological stress in our experimental model was confirmed by increase in urinary corticosterone level on day 7 of restraint regimen. Regardless of Fe-TBI, CRIPS reduced splenocyte number per spleen at the end of the 28-day restraint regimen. At 2 Gy, Fe-TBI alone induced many aberrant chromosomes and no modifying effect was detected from CRIPS on induction of aberrant chromosomes. Notably, neither Fe-TBI at 0.1 Gy nor CRIPS alone induced any increase in the frequency of aberrant chromosomes, while simultaneous exposure resulted in a significant increase in the frequency of chromosomal exchanges. These findings clearly showed that CRIPS could enhance the frequency of chromosomal exchanges induced by Fe-TBI at a low dose of 0.1 Gy