Shared Biological Pathways Between Alzheimer’s Disease and Ischemic Stroke

Alzheimer’s disease (AD) and ischemic stroke (IS) are an immense socioeconomic burden worldwide. There is a possibility that shared genetic factors lead to their links at epidemiological and pathophysiological levels. Although recent genome-wide association studies (GWAS) have provided profound insights into the genetics of AD and IS, no shared genetic variants have been identified to date. This prompted us to initiate this study, which sought to identify shared pathways linking AD and IS. We took advantage of large-scale GWAS summary data of AD (17,008 AD cases and 37,154 controls) and IS (10,307 cases and 19,326 controls) to conduct pathway analyses using genetic pathways from multiple well-studied databases, including GO, KEGG, PANTHER, Reactome, and Wikipathways. Collectively, we discovered that AD and IS shared 179 GO categories (56 biological processes, 95 cellular components, and 28 molecular functions); and the following pathways: six KEGG pathways; two PANTHER pathways; four Reactome pathways; and one in Wikipathways pathway. The more fine-grained GO terms were mainly summarized into different functional categories: transcriptional and post-transcriptional regulation, synapse, endocytic membrane traffic through the endosomal system, signaling transduction, immune process, multi-organism process, protein catabolic metabolism, and cell adhesion. The shared pathways were roughly classified into three categories: immune system; cancer (NSCLC and glioma); and signal transduction pathways involving the cadherin signaling pathway, Wnt signaling pathway, G-protein signaling and downstream signaling mediated by phosphoinositides (PIPs). The majority of these common pathways linked to both AD and IS were supported by convincing evidence from the literature. In conclusion, our findings contribute to a better understanding of common biological mechanisms underlying AD and IS and serve as a guide to direct future research

Experimental and theoretical analysis of fatigue properties of liner for the large pressure equipment

In order to analyze the working status of the key components of large-width device online, taking liners force status as the object of study before and after reformation of the liners. Specifications for the slab: 230mmx1300mmx2600mm, the initial temperature is 1020 °C, the amount of lateral pressure is 228mm, and the angle of the die is 12°. Using the main tool of frequency fatigue testing machine with the model of PLG-100C, based on the principle of up and down, and it can obtain the distribution rulers of testing and experimental by the method of directly stick the strain chip on the liners. The result of study indicates that it can provide the theoretical basis for the reformation of the liner and the analysis of stress state of large the lateral pressure equipment

Flexible impulse response of the multi-bar linkage with heavy load

It is based on the advantages of virtual prototyping technology, the dynamics mathematic model was established for the large mechanism by applying multi body dynamics theory. In order to adapt the users to special request of the strip width size, appeared the continuous casting and continuous rolling technology, and greatly reduce the width types of continuous casting. The components of the equipments are often considered the rigid body. The precision is not high premise in the process of work, usually the parts works as elastic under the high speed and the heavy load, neglects various components the elastic function will cause the result error, even will be wrong. Studied analysis dynamic characteristic of the adjustment width machine, and analyzed the component in detail for the rigid body or the elastic. The results provide the theoretically support to work out adjustment the width potentialities and strength analysis of the key parts

Shared Gene Expression Between Multiple Sclerosis and Ischemic Stroke

Patients with multiple sclerosis (MS) appear to have an increased risk of ischemic stroke (IS). Although MS and IS have very different phenotypes, gene-based and pathway-based analyses of large-scale genome-wide association studies (GWAS) have increasingly enhanced our understanding of these two diseases. Whether there are common molecular mechanisms connecting MS and IS is still unclear. Here, we describe the outcome of gene-based test and pathway-based analysis of GWAS datasets that explored potential gene expression links between MS and IS. After identifying significant gene sets individually of MS and IS, we performed pathway-based analysis in four biological pathway databases (KEGG, PANTHER, REACTOME, and WikiPathways) and GO categories. We discovered that there were 9 shared pathways between MS and IS in KEGG, 2 in PANTHER, 14 in REACTOME, 1 in WikiPathways, and 194 in GO annotations (p < 0.05). These results provide an improved understanding about possible shared mechanisms and treatments strategies for MS and IS. They also provide some basis for further studies of how these two diseases are linked at the molecular level

Identification of Shared Genes Between Ischemic Stroke and Parkinson's Disease Using Genome-Wide Association Studies

Ischemic stroke (IS) and Parkinson's disease (PD) are two neurological diseases that often strike individuals of advanced age. Although thought of as a disease of old age, PD can occur in younger patients. In many of these cases, genetic mutations underlie the disease. As with PD, stroke can also have a genetic component. Although many of the risk factors for IS are considered to be modifiable, a significant portion is not, suggesting that some of stroke risk factors may have a genetic origin. Large-scale genome-wide association studies (GWAS) have identified several IS and PD gene variants recently. Converging epidemiologic and pathological evidence suggests that IS and PD may be linked. However, it is still unclear whether these two conditions share a common mechanism. Here, we sought to determine the genetic mechanism underlying the possible association between IS and PD. We conducted a multi-step systemic analysis comprising (1) identification of IS and PD variants validated by known GWAS, (2) two separate gene-based tests using Versatile Gene-based Association Study 2 (VEGAS2) and PLINK, (3) a transcriptome-wide association study (TWAS), and (4) analyses of gene expression using an online tool in Gene Expression Omnibus. Our investigation revealed that IS and PD have in common five shared genes: GPX7, LBH, ZCCHC10, DENND2A, and NUDT14, which pass gene-based tests. Functionally, these genes are expressed differentially in IS and PD patients compared to neurologically healthy control subjects. This genetic overlap may provide clues on how IS and PD are linked mechanistically. This new genetic insight into these two diseases may be very valuable for narrowing the focus of future studies on the genetic basis of IS and PD and for developing novel therapies

Data processing system of continuous temperature measurement for liquid steel

Six different methods of accurate measurement of the temperature of liquid steel in real time are analyzed. Using a comparison and analysis, a fast and accurate mathematical model is obtained.Проведен анализ шести различных методов точного измерения температуры жидкой стали в реальном времени. С помощью сравнения и анализа результатов получена быстрая и точная математическая модель.Проведено аналіз шести різних методів точного вимірювання температури рідкої сталі в реальному часі. . За допомогою порівняння і аналізу результатів отримана швидка і точна математична модель

Seasonal variations of C-1-C-4 alkyl nitrates at a coastal site in Hong Kong: Influence of photochemical formation and oceanic emissions

Five C-1-C-4 alkyl nitrates (RONO2) were measured at a coastal site in Hong Kong in four selected months of 2011 and 2012. The total mixing ratios of C-1-C-4 RONO2 (Sigma 5RONO2) ranged from 15.4 to 143.7 pptv with an average of 65.9 +/- 33.0 pptv. C-3-C-4 RONO2 (2-butyl nitrate and 2-propyl nitrate) were the most abundant RONO2 during the entire sampling period. The mixing ratios of C-3-C-4 RONO2 were higher in winter than those in summer, while the ones of methyl nitrate (MeONO2) were higher in summer than those in winter. Source analysis suggests that C-2-C-4 RONO2 were mainly derived from photochemical formation along with biomass burning (58.3-71.6%), while ocean was a major contributor to MeONO2 (53.8%) during the whole sampling period. The photochemical evolution of C-2-C-4 RONO2 was investigated, and found to be dominantly produced by the parent hydrocarbon oxidation. The notable enrichment of MeONO2 over C-3-C-4 RONO2 was observed in a summer episode when the air masses originating from the South China Sea (SCS) and MeONO2 was dominantly derived from oceanic emissions. In order to improve the accuracy of ozone (O-3) prediction in coastal environment, the relative contribution of RONO2 from oceanic emissions versus photochemical formation and their coupling effects on O-3 production should be taken into account in future studies. (C) 2017 Elsevier Ltd. All rights reserved