15 research outputs found

    Practical Parallel Algorithms for Non-Monotone Submodular Maximization

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    Submodular maximization has found extensive applications in various domains within the field of artificial intelligence, including but not limited to machine learning, computer vision, and natural language processing. With the increasing size of datasets in these domains, there is a pressing need to develop efficient and parallelizable algorithms for submodular maximization. One measure of the parallelizability of a submodular maximization algorithm is its adaptive complexity, which indicates the number of sequential rounds where a polynomial number of queries to the objective function can be executed in parallel. In this paper, we study the problem of non-monotone submodular maximization subject to a knapsack constraint, and propose the first combinatorial algorithm achieving an (8+ϵ)(8+\epsilon)-approximation under O(logn)\mathcal{O}(\log n) adaptive complexity, which is \textit{optimal} up to a factor of O(loglogn)\mathcal{O}(\log\log n). Moreover, we also propose the first algorithm with both provable approximation ratio and sublinear adaptive complexity for the problem of non-monotone submodular maximization subject to a kk-system constraint. As a by-product, we show that our two algorithms can also be applied to the special case of submodular maximization subject to a cardinality constraint, and achieve performance bounds comparable with those of state-of-the-art algorithms. Finally, the effectiveness of our approach is demonstrated by extensive experiments on real-world applications.Comment: Part of the contribution appears in AAAI-202

    Single-nanowire spectrometers.

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    Spectrometers with ever-smaller footprints are sought after for a wide range of applications in which minimized size and weight are paramount, including emerging in situ characterization techniques. We report on an ultracompact microspectrometer design based on a single compositionally engineered nanowire. This platform is independent of the complex optical components or cavities that tend to constrain further miniaturization of current systems. We show that incident spectra can be computationally reconstructed from the different spectral response functions and measured photocurrents along the length of the nanowire. Our devices are capable of accurate, visible-range monochromatic and broadband light reconstruction, as well as spectral imaging from centimeter-scale focal planes down to lensless, single-cell-scale in situ mapping.EPSRC (EP/M013812/1, EP/L016087/1), the Royal Commission for the Exhibition of 1851, CRUK Pioneer Award (C55962/A24669), , Business Finland (A-Photonics), Academy of Finland, ERC (834742), EU Horizon 2020 (820423), the Cambridge Trust, the Royal Society

    Joint Optimization of Trajectory and Discrete Reflection Coefficients for UAV-Aided Backscatter Communication System with NOMA

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    Backscatter communication is a promising technology for the Internet of Things (IoT) systems with low-energy consumption, in which the data transmission of the backscatter devices relies on reflecting the incident signal. However, limited by the low power characteristic of the reflected signal from backscatter devices, achieving efficient data collection for the widely distributed backscatter devices is a thorny problem. Considering that unmanned aerial vehicles (UAVs) have flexible deployment capability, employing UAVs in a backscatter communication network can achieve feasible data collection for backscatter devices. In this paper, we consider a UAV-aided backscatter system and introduce Non-orthogonal multiple access (NOMA) to enable the UAV to collect signals from multiple backscatter devices simultaneously. We formulate an optimization problem to maximize the communication throughput of the considered system by jointly designing the backscatter device matching, the trajectory of the UAV, and the reflection coefficients of the backscatter devices, which is a non-convex optimization problem and challenging to solve. Hence, we decouple the original problem into three sub-problems and propose an efficient iterative algorithm based on Block Coordinate Descent (BCD) to solve them. In detail, a game-based matching algorithm is designed to ensure the transmission needs of remote backscatter devices. The UAV trajectory and reflection coefficients of backscatter devices are optimized through the Successive Convex Approximation (SCA) algorithm and relaxation algorithm. By iterative optimization of the sub-problems, the original problem is solved. The simulation results show that the proposed scheme can obtain a significant throughput gain compared to benchmark schemes

    Spatial evolution investigation and analysis of traditional dwellings in Dongzhu Island village of Jiaodong region

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    The seaweed cottage is a traditional residence in the Jiaodong (胶东) region that has existed for hundreds of years. During its development, its architectural form was evidently reconstructed and redeveloped. Based on historical documents, interviews, field investigations, and mapping, the author summarizes the village environment, overall layout, and architectural attributes of Dongchu Island Village (东褚岛村, DIV) to address the common needs of historical heritage protection. In order to examine in depth, the spatial evolution of the five stages in the past one hundred years, the Wangs’ grocery seaweed courtyard located on the southwest corner of Middle Street was selected as a typical research object. Analyzed as two clues, the village and dwelling, three key factors are identified as influencing spatial change: Characteristics of the time, economic industry, and personnel structure

    Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells

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    Autophagy has been recognized as a stress tolerance mechanism that maintains cell viability, which contributes to tumor progression, dormancy, and treatment resistance. The inhibition of autophagy in cancer has the potential to improve the therapeutic efficacy. It is therefore of great significance to search for new autophagy inhibitors. In the present study, after screening a series of curcumin derivatives synthesized in our laboratory, (E)-3-((E)-4-chlorobenzylidene)-5-((5-methoxy-1H-indol-3-yl)methylene)-1-methylpiperidin-4-one (CB-2) was selected as a candidate for further study. We found that CB-2 increased the LC3B-II and SQSTM1 levels associated with the accumulation of autophagosomes in non-small cell lung cancer (NSCLC) A549 cells. The increased level of LC3B-II induced by CB-2 was neither eliminated when autophagy initiation was suppressed by wortmannin nor further increased when autophagosome degradation was inhibited by chloroquine (CQ). CB-2 enhanced the accumulation of LC3B-II under starvation conditions. Further studies revealed that CB-2 did not affect the levels of the key proteins involved in autophagy induction but significantly blocked the fusion of autophagosomes with lysosomes. High-dose CB-2 induced the apoptosis and necrosis of A549 cells, while a lower dose of CB-2 mainly impaired the migrative capacity of A549 cells, which only slightly induced cell apoptosis. CB-2 increased the levels of mitochondrial-derived reactive oxygen species (ROS) while decreasing the mitochondrial membrane potential (MMP). Scavenging ROS via N-acetylcysteine (NAC) reversed CB-2-induced autophagy inhibition and its inhibitory effect against A549 cells. In conclusion, CB-2 serves as a new late-stage autophagy inhibitor, which has a strong inhibitory potency against A549 cells

    Miniaturized Spectrometers with a Tunable van der Waals Junction

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    Miniaturized computational spectrometers, which can obtain incident spectra using a combination of device spectral response and reconstruction algorithms, are essential for on-chip and implantable applications. Highly sensitive spectral measurement using a single detector allows the footprints of such spectrometers to be scaled down while achieving spectral resolution approaching that of benchtop systems. We report a high-performance computational spectrometer based on a single van der Waals junction with an electrically tunable transport-mediated spectral response. We achieve high peak wavelength accuracy (~0.36 nanometers), high spectral resolution (~3 nanometers), broad operation bandwidth (from ~405 to 845 nanometers), and proof-of-concept spectral imaging. Our approach provides a route toward ultraminiaturization and offers unprecedented performance in accuracy, resolution, and operation bandwidth for single-detector computational spectrometers.EP/T014601/
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