Kuća o batani = Casa della batana

Jedinstveni multidisciplinarni projekt na Jadranu Kuća o batani / Casa della batana nastao je s ciljem istraživanja, zaštite, prenošenja i prezentacije materijalne i nematerijalne pomorske baštine povezane s rovinjskom ribarskom brodicom batanom, te radi obogaćivanja ponude kulturnog turizma Rovinja, Istre i Hrvatske. Misao vodilja projekta sagledava batanu kao lokalnu pojavu oko koje se sustavno njeguje i učvršćje lokalni identitet grada i njegovih građana, ali za projekt nije ništa manje važno sagledavanje batane kao medija komunikacije i međukulturne razmjene na Jadranu i Mediteranu

A study on parking availability index within the vicinity of De La Salle University-Manila

Parking facilities within the vicinity of De La Salle University-Manila are increasing in demand but the capacity is always limited to accommodate few automobiles at a time from the dozens of students, faculty, and staff members coming to the institution. As a result, alternatives such as on-street parking and idling contributes to traffic not to mention inconveniences brought by these alternatives and its effects. Hence, statistical analysis and data gathering were conducted on mostly frequented parking facilities with a high rate of turnover per quarter of an hour which determines the most probable facility to find a parking space during peak hours. Tha parking facilities observed were the Gonzales Hall and the Razon Sports Complex of the University, Harrison Plaza, Green Court, McDonalds-Taft, Beach parking area, Barn parking area, Leon Guinto parking and Burgundy condominium with a vehicular capacity of 94, 242, 334, 48, 25, 100, 34, 84 and 40 respectively. To generalize the findings for the several parking facilities around campus, a program called Quantum Global Information System (QGIS) is used to create a visual representation of the vicinity including parking spaces available. The software would benefit the community as it aims to inform car parkers of the availability of various parking facilities including available slots and the turnover rate

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

BACKGROUND: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. METHODS: To identify genetic loci associated with ischaemic stroke, we did a two-stage GWAS. In the first stage, we included 16 851 cases with state-of-the-art phenotyping data and 32 473 stroke-free controls. Cases were aged 16 to 104 years, recruited between 1989 and 2012, and subtypes of ischaemic stroke were recorded by centrally trained and certified investigators who used the web-based protocol, Causative Classification of Stroke (CCS). We constructed case-control strata by identifying samples that were genotyped on nearly identical arrays and were of similar genetic ancestral background. We cleaned and imputed data by use of dense imputation reference panels generated from whole-genome sequence data. We did genome-wide testing to identify stroke-associated loci within each stratum for each available phenotype, and we combined summary-level results using inverse variance-weighted fixed-effects meta-analysis. In the second stage, we did in-silico lookups of 1372 single nucleotide polymorphisms identified from the first stage GWAS in 20 941 cases and 364 736 unique stroke-free controls. The ischaemic stroke subtypes of these cases had previously been established with the Trial of Org 10 172 in Acute Stroke Treatment (TOAST) classification system, in accordance with local standards. Results from the two stages were then jointly analysed in a final meta-analysis. FINDINGS: We identified a novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke (first stage odds ratio [OR] 1·21, 95% CI 1·13-1·30, p=4·50 × 10-8; joint OR 1·19, 1·12-1·26, p=1·30 × 10-9). Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10-19; joint OR 1·37, 1·30-1·45, p=2·79 × 10-32) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10-7; joint OR 1·17, 1·11-1·23, p=2·29 × 10-10) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10-8; joint OR 1·24, 1·15-1·33, p=4·52 × 10-9) for large artery atherosclerosis stroke. The 12q24 locus near ALDH2, which has previously been associated with all ischaemic stroke but not with any specific subtype, exceeded genome-wide significance in the meta-analysis of small artery stroke (first stage OR 1·20, 1·12-1·28, p=6·82 × 10-8; joint OR 1·17, 1·11-1·23, p=2·92 × 10-9). Other loci associated with stroke in previous studies, including NINJ2, were not confirmed. INTERPRETATION: Our results suggest that all ischaemic stroke-related loci previously implicated by GWAS are subtype specific. We identified a novel gene associated with large artery atherosclerosis stroke susceptibility. Follow-up studies will be necessary to establish whether the locus near TSPAN2 can be a target for a novel therapeutic approach to stroke prevention. In view of the subtype-specificity of the associations detected, the rich phenotyping data available in the Stroke Genetics Network (SiGN) are likely to be crucial for further genetic discoveries related to ischaemic stroke