The tidyomics ecosystem: Enhancing omic data analyses

The growth of omic data presents evolving challenges in data manipulation, analysis, and integration. Addressing these challenges, Bioconductor1 provides an extensive community-driven biological data analysis platform. Meanwhile, tidy R programming2 offers a revolutionary standard for data organisation and manipulation. Here, we present the tidyomics software ecosystem, bridging Bioconductor to the tidy R paradigm. This ecosystem aims to streamline omic analysis, ease learning, and encourage cross-disciplinary collaborations. We demonstrate the effectiveness of tidyomics by analysing 7.5 million peripheral blood mononuclear cells from the Human Cell Atlas3, spanning six data frameworks and ten analysis tools.Competing Interest StatementR.G. has received consulting income from Takeda and Sanofi, and declares ownership in Ozette Technologies. M.K. is an employee of and declares ownership in Achilles Therapeutics. ​​The remaining authors declare no competing interests

Encryption and Information Assurance

Moderator: Peter D. Feaver, Assistant Professor, Department of Political Science, Duke University Panelists: F. Lynn McNulty, Director of Government Affairs, RSA Data Security William P. Crowell, Vice President for Product Management and Strategy, Cylink Corporation Marc Rotenberg, Director, Electronic Privacy and Information Cente

Psychosocial Correlates of Religious Approaches to Same-Sex Attraction: A Mormon Perspective

This study examined the psychosocial correlates of following various church-based approaches for dealing with same-sex attraction, based on a large sample (1,612) of same-sex attracted current and former members of the Church of Jesus Christ of Latter-day Saints (LDS, or Mormon). Overall, this study found that biologically based views about the etiology of same-sex attraction (vs. psychosocial views), LDS church disaffiliation (vs. activity), sexual activity (vs. celibacy), and legal same-sex marriage (vs. remaining single or mixed-orientation marriage) were all associated with significantly higher levels of self-esteem and quality of life, and lower levels of internalized homophobia, sexual identity distress, and depression. The divorce rate for mixed-orientation marriages was 51% at the time of survey completion, with projections suggesting an eventual divorce rate of 69%

Sexual Orientation Change Efforts Through Psychotherapy for LGBQ Individuals Affiliated with the Church of Jesus Christ of Latter-Day Saints

This study reports the results of a comprehensive online survey of 1,612 current or former members of the Church of Jesus Christ of Latter-day Saints, many of whom engaged in psychotherapy to cope with (i.e., understand, accept, or change) their same-sex attractions. Data obtained from written and quantitative responses showed that therapy was initiated over a very wide age range and continued for many years. However, counseling was largely ineffective; less than 4% reported any modification of core same-sex erotic attraction. Moreover, 42% reported that their change-oriented therapy was not at all effective, and 37% found it to be moderately to severely harmful. In contrast, affirming psychotherapeutic strategies were often found to be beneficial in reducing depression, increasing self-esteem, and improving family and other relationships. Results suggest that the very low likelihood of a modification of sexual orientation and the ambiguous nature of any such change should be important considerations for highly religious sexual minority individuals considering reorientation therapy

A Mixed Methods Analysis of the Family Support Experiences of GLBQ Latter Day Saints

A burgeoning vein of research assesses links between familial support and psychosocial health among gay, lesbian, bisexual, and queer or questioning (GLBQ) individuals. This study is a cross-sectional, multimethod survey that examined these associations in highly religious families. Participants were 587 individuals who identified as GLBQ, were affiliated with the Church of Jesus Christ of Latter Day Saints (LDS), and were between the ages of 18 and 30. Reports of early support from families were significantly associated with various measures of psychosocial health, more consistently for men than women. In addition, participants provided written narratives in response to an open-ended question asking about the reactions of their parents, family members, and faith community when they disclosed their nonheterosexual orientation. Analyses yielded a continuum of reactions with an overarching religious influence: (1) positive or affirming (2) a conditionally positive response (3) avoidance (4) distress or guilt and (5) anger or hostility. Within the nonaffirming range of responses, subthemes emerged related to specific patterns of condemnation of the person\u27s nonheterosexual identity, including (1) change over time, and (2) embracing myth. Participants\u27 own words are used to provide depth and richness to the observed themes

Sexual Orientation Change Efforts Among Current or Former LDS Church Members

This study examined sexual orientation change efforts (SOCE) by 1,612 individuals who are current or former members of the Church of Jesus Christ of Latter-day Saints (LDS). Data were obtained through a comprehensive online survey from both quantitative items and open-ended written responses. A minimum of 73% of men and 43% of women in this sample attempted sexual orientation change, usually through multiple methods and across many years (on average). Developmental factors associated with attempts at sexual orientation change included higher levels of early religious orthodoxy (for all) and less supportive families and communities (for men only). Among women, those who identified as lesbian and who reported higher Kinsey attraction scores were more likely to have sought change. Of the 9 different methods surveyed, private and religious change methods (compared with therapist-led or group-based efforts) were the most common, started earlier, exercised for longer periods, and reported to be the most damaging and least effective. When sexual orientation change was identified as a goal, reported effectiveness was lower for almost all of the methods. While some beneficial SOCE outcomes (such as acceptance of same-sex attractions and reduction in depression and anxiety) were reported, the overall results support the conclusion that sexual orientation is highly resistant to explicit attempts at change and that SOCE are overwhelmingly reported to be either ineffective or damaging by participants