Experimental studies on the aerodynamic performance and dynamic response of flow direction sensing vanes

Systematic investigations were performed on a variety of aerodynamic surfaces to obtain their potential for possible application to wind vanes. Among the surfaces tested were: (1) single vanes consisting of flat plates of various planforms having aspect ratios between 0.5 and 5; (2) bi-vanes with aspect ratio 2.5; (3) various cone and box vanes; and (4) various cruciform configurations. The models were subjected to windtunnel tests. In addition to lift and drag force measurements, damping and frequency test were performed under a variety of flow conditions

Fast response vanes for sensing flow patterns in helicopter rotor environment

Wind tunnel experiments were conducted on four small-scale flow-direction vanes for the determination of aerodynamic response. The tests were further extended to include a standard sized low-inertia vane currently employed in aircraft flight testing. The four test vanes had different aspect ratios and were about 35 percent of the surface area of the standard vane. The test results indicate satisfactory damping and frequency response for all vanes tested and compare favorably with the standard design

Power requirement of rotating rods in airflow

Experiments were performed to determine the power required for rotating a rotor disc fitted with a number of radially arranged rods placed into a ducted airflow. An array of stationary rods, also radially arranged, were placed upstream close to the rotor with a small gap between the rods to cause wake interference. The results show that power increased with increasing airflow and the rate of increase varied considerably. At lower values of airflow the rate of increase was larger than at higher airflow and definite power peaks occurred at certain airflow rates, where the power attained a maximum within the test airflow range. During the test a maximum blade passage frequency of 2037 Hz was attained

Fragment screening reveals salicylic hydroxamic acid as an inhibitor of <em>Trypanosoma brucei</em> GPI GlcNAc-PI de-N-acetylase

The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. We screened a focused library of zinc-binding fragments and identified salicylic hydroxamic acid as a GlcNAc-PI de-N-acetylase inhibitor with high ligand efficiency. This is the first small molecule inhibitor reported for the trypanosome GPI pathway. Investigating the structure activity relationship revealed that hydroxamic acid and 2-OH are essential for potency, and that substitution is tolerated at the 4- and 5-positions

Wave equations for the perturbations of a charged black hole

A pair of simple wave equations is presented for the symmetric gravitational and electromagnetic perturbations of a charged black hole. One of the equations is uncoupled, and the other has a source term given by the solution of the first equation. The derivation is presented in full detail for either axially symmetric or stationary perturbations, and is quite straightforward. This result is expected to have important applications in astrophysical models.Comment: 4 page

Changes in Assortative Matching and Inequality in Income: Evidence for the UK

The extent to which like‐with‐like marry is important for inequality as well as for the outcomes of children who result from the union. In this paper, we present evidence on changes in assortative mating and its implications for household inequality in the UK. Our approach contrasts with others in the literature in that it is consistent with an underlying model of the marriage market. We argue that a key advantage of this approach is that it creates a direct connection between changes in assortativeness in marriage and changes in the value of marriage for the various possible matches by education group. Our empirical results do not show a clear direction of change in assortativeness in the UK between the birth cohorts of 1945–54 and 1965–74. We find that changes in assortativeness pushed income inequality up slightly, but that the strong changes in education attainment across the two cohorts contributed to scale down inequality

Microdosimetry of photoneutrons around medical linear accelerators.

Photoneutrons produced in the vicinity of medical linear accelerators for therapy, constitute a hazard which is difficult to assess and monitor. The aims of the project were to develop new techniques, using microdosimetry, which would be suitable for the improved quality control of pulsed photon beams and for the assessment of the associated photoneutron hazard in typical treatment facilities from the perspective of the patients and staff. The measurements of photoneutron yields and equivalent doses were obtained using activation analysis detectors around a 10 MV LINAC. To obtain adequate statistical precision, an optimum thickness of 2.5 cm of polyethylene was used that doubled the detector's sensitivity. This enabled the yields and spatial distribution of the low intensity field to be recorded. Photoneutron equivalent dose-rates of up to 0.104 Sv.h-1, or 0.1% of the useful photon dose- rates, were measured. In the literature, however, it was found that equivalent dose-rates could reach as high as 1 % of the useful photon treatment dose-rate for machines operating at X ray energies of &ge;18 MV. Thus it is recommended that to uphold the principle of ALARA, such high energies (&ge;18 MV) should only be used when no lower energy machine is available. Microdosimetry with a tissue equivalent proportional counter (TEPC) microdosimeter, enabled the photoneutron contribution to the quality spectrum to be identified in the maze to the treatment room of the 10 MV LIN AC, and the photoneutrons there were assigned a radiation weighting factor of 20. The known problems concerning the rf interference and very high pulsed dose-rates inside the treatment room proved too severe to obtain meaningful results with the TEPC. The microdosimeter did however provide useful diagnostic information. Furthermore, a novel calibration technique for TEPC's was developed and an established one, the proton-edge method, was improved. A new approach was adopted to conduct microdosimetry in the vicinity of medical accelerators. This involved the design of a condensed phase microdosimeter comprising, a miniature CsI(T1) scintillator coupled to an optical fibre 20 m long, for conducting in-beam, on-line measurements of quality spectra. However, Cerenkov light and scintillation light produced in the optical fibre by the radiation fields was the cause of strong interference that has yet to be overcome. The application of the microdosimeter, which is still under development, to brachytherapy is proposed for in-vivo measurements

Drought: Understanding and reducing vulnerability through monitoring and early warning systems. Report of the DrIVER workshop, 17 March 2015.

As part of the Belmont Forum funded international DRIVER research project on linking indicators to impacts to improve drought monitoring and early warning systems (MEWs), a stakeholder workshop was held on 17th March 2015 in Wallingford, UK. The workshop was attended by representatives of various UK organisations with an interest in drought and MEWs and DRIVER researchers from the Centre for Ecology and Hydrology (UK), Open University (UK), University of Freiburg (Germany), National Drought Mitigation Center (USA) and CSIRO (Australia). The aims of the workshop were to introduce participants to the DRIVER project and recent RCUK drought projects; engage with stakeholders’ experiences, understandings and needs in relation to droughts; and identify needs for future MEWs. The design of the workshop was based on a commitment to social learning. It comprised a mix of presentations and interactive sessions using innovative techniques to develop collective insights, enabling participants to learn from others and contribute their experiences and ideas and concerns in relation to drought and MEWs. Themes emerging findings from the workshop were wide-ranging, but point to a range of issues, concerns and suggestions for improving drought management and MEWs centred on: recognition of different types of drought; uncertainties and risks relating to indicators; forecasting; impacts; politics of drought; public communication; role of stakeholders; and resilience strategies. The workshop suggests different ways of thinking and acting are required about drought and MEWs in particular. The discussions and presentations also suggest the complexity of droughts requires a more systemic understanding of drought policy, processes and practices in order to determine the role of MEWs and how these can be improved by linking indicators to impacts. The output of the workshop constitute a key source for informing and shaping ongoing DRIVER research activities and other events convened by RCUK drought research projects

Using mental-modelling to explore how irrigators in the Murray-Darling Basin make water-use decisions

Study region: Water stress and over-allocation are at the forefront of water management and policy challenges in Australia, especially in the Murray–Darling Basin (MDB). Because irrigated agriculture is a major social and economic component of the MDB, farmer decision-making plays a major role in water sustainability in the region. Study focus: This study used a fuzzy cognitive mapping methodology, ‘mental modeling’, to understand the perceived constraints of irrigator water-use decisions in the MDB, for two different types of irrigation: permanent and annual crops. The approach elicits and documents irrigator insights into the complex and networked nature of irrigation water use decisions in relation to farm-based dynamics. New hydrological insights for the region: Results suggest support for greater local and irrigator involvement in water management decisions. Many, if not most, of the irrigators understood the need for, or at least the inevitability of, governmental policies and regulations. However, a lack of accountability, predictability, and transparency has added to the uncertainty in farm-based water decision-making. Irrigators supported the concept of environmental sustainability, although they might not always agree with how the concept is implemented. The mental modelling approach facilitated knowledge sharing among stakeholders and can be used to identify common goals. Future research utilizing the mental modelling approach may encourage co-management and knowledge partnerships between irrigators, water managers and government officials.Ellen M. Douglas, Sarah Ann Wheeler, David J. Smith, Ian C. Overton, Steven A. Gray, Tanya M. Doody, Neville D. Crossma

A novel mouse model of in situ stenting

AIMS: Animal models of stenting are mostly limited to larger animals or involve substantial abdominal surgery in rodents. We aimed to develop a simple, direct model of murine stenting. METHODS AND RESULTS: We designed a miniature, self-expanding, nitinol wire coil stent that was pre-loaded into a metal stent sheath. This was advanced into the abdominal aorta of the mouse, via femoral access, and the stent deployed. In-stent restenosis was investigated at 1, 3, 7, and 28 days post-stenting. The model was validated by investigation of neointima formation in mice deficient in signalling via the interleukin-1 receptor (IL-1R1), compared with other injury models. Ninety-two per cent of mice undergoing the procedure were successfully stented. All stented vessels were patent. Inflammatory cells were seen in the adventitia and around the stent strut up to 3 days post-stenting. At 3 days, an early neointima was present, building to a mature neointima at 28 days. In mice lacking IL-1R1, the neointima was 64% smaller than that in wild-type controls at the 28-day timepoint, in agreement with other models. CONCLUSION: This is the first description of a successful model of murine in situ stenting, using a stent specifically tailored for use in small thin-walled arteries. The procedure can be undertaken by a single operator without the need for an advanced level of microsurgical skill and is reliable and reproducible. The utility of this model is demonstrated by a reduction in in-stent restenosis in IL-1R1-deficient mice