Acute Care Physical Therapy Management Of A Former Professional Athlete Following Unicompartmental Knee Arthroplasty: A Case Report

Background: Unicompartmental knee arthroplasty (UKA): replacement of one compartment of the tibiofemoral joint. A balance between an ambitious plan of care and mindfulness of the acute inflammatory process poses a challenge for acute care physical therapists. There is a lack of literature that addresses the acute care physical therapy management of patients who have undergone this procedure. Specifically, little is known about the acute care physical therapy management of former elite athletes who undergo UKA in middle age. Purpose: To describe the acute care physical therapy management of a former professional tennis player immediately following UKA.https://dune.une.edu/pt_studcrposter/1005/thumbnail.jp

Habitat-mediated dive behavior in free-ranging grey seals

Understanding the links between foraging behaviour and habitat use of key species is essential to addressing fundamental questions about trophic interactions and ecosystem functioning. Eight female grey seals (Halichoerus grypus) were equipped with time-depth recorders linked to Fastloc GPS tags following the annual moult in southwest Ireland. Individual dives were coupled with environmental correlates to investigate the habitat use and dive behaviour of free-ranging seals. Dives were characterised as either pelagic, benthic, or shallow (where errors in location and charted water depth made differentiating between pelagic and benthic dives unreliable). Sixty-nine percent of dives occurring in water >50 m were benthic. Pelagic dives were more common at night than during the day. Seals performed more pelagic dives over fine sediments (mud/sand), and more benthic dives when foraging over more three-dimensionally complex rock substrates. We used Markov chain analysis to determine the probability of transiting between dive states. A low probability of repeat pelagic dives suggests that pelagic prey were encountered en route to the seabed. This approach could be applied to make more accurate predictions of habitat use in data-poor areas, and investigate contentious issues such as resource overlap and competition between top predators and fisheries, essential for the effective conservation of these key marine species

Spatial overlap of grey seals and fisheries in Irish waters, some new insights using telemetry technology and VMS

Seals and humans often target the same food resource, leading to competition. This is of mounting concern with fish stocks in global decline. Grey seals were tracked from southeast Ireland, an area of mixed demersal and pelagic fisheries, and overlap with fisheries on the Celtic Shelf and Irish Sea was assessed. Overall, there was low overlap between the tagged seals and fisheries. However, when we separate active (e.g. trawls) and passive gear (e.g. nets, lines) fisheries, a different picture emerged. Overlap with active fisheries was no different from that expected under a random distribution, but overlap with passive fisheries was significantly higher. This suggests that grey seals may be targeting the same areas as passive fisheries and/or specifically targeting passive gear. There was variation in foraging areas between individual seals suggesting habitat partitioning to reduce intra-specific competition or potential individual specialisation in foraging behaviour. Our findings support other recent assertions that seal/fisheries interactions in Irish waters are an issue in inshore passive fisheries, most likely at the operational and individual level. This suggests that seal population management measures would be unjustifiable, and mitigation is best focused on minimizing interactions at nets

Development of a luciferase-based reporter system to monitor Bifidobacterium breve UCC2003 persistence in mice

<p>Abstract</p> <p>Background</p> <p>Probiotics such as bifidobacteria have been shown to maintain a healthy intestinal microbial balance and help protect against infections. However, despite these benefits, bifidobacteria still remain poorly understood at the biochemical, physiological and especially the genetic level. Herein we describe, for the first time, the development of a non-invasive luciferase-based reporter system for real-time tracking of <it>Bifidobacterium </it>species <it>in vivo</it>.</p> <p>Results</p> <p>The reporter vector pLuxMC1 is based on the recently described theta-type plasmid pBC1 from <it>B. catenatulatum </it><abbrgrp><abbr bid="B1">1</abbr></abbrgrp> and the <it>luxABCDE </it>operon from pPL2lux <abbrgrp><abbr bid="B2">2</abbr></abbrgrp>. Derivatives of pLuxMC1, harbouring a bifidobacterial promoter (pLuxMC2) as well as a synthetically derived promoter (pLuxMC3) <abbrgrp><abbr bid="B3">3</abbr></abbrgrp> placed upstream of <it>luxABCDE</it>, were constructed and found to stably replicate in <it>B. breve </it>UCC2003. The subsequent analysis of these strains allowed us to assess the functionality of pLuxMC1 both <it>in vitro </it>and <it>in vivo</it>.</p> <p>Conclusion</p> <p>Our results demonstrate the potential of pLuxMC1 as a real-time, non-invasive reporter system for <it>Bifidobacterium</it>. It has also allowed us, for the first time, to track the colonisation potential and persistence of this probiotic species in real time. An interesting and significant outcome of the study is the identification of the caecum as a niche environment for <it>B. breve </it>UCC2003 within the mouse gastrointestinal tract (GI) tract.</p

Using population viability analysis to examine the potential long-term impact of fisheries bycatch on protected species

Fisheries bycatch is recognised as the dominant anthropogenic threat facing many protected species globally. Estimates of total bycatch are often associated with wide confidence intervals as a result of limited coverage by on-board observers. This makes it difficult for managers to assess risk and design effective management plans. Here, we present a case study of grey seal (Halichoerus grypus) bycatch in static net fisheries across Irish waters, where potentially unsustainable bycatch levels have been reported with typically wide confidence intervals. We used Population Viability Analysis (PVA) to explore potential bycatch scenarios at a national level in order to inform future monitoring and management efforts; including (i) a baseline scenario where the probability of seals becoming bycaught was independent of age and sex; (ii) probability was biased towards juvenile, male, or female seals; (iii) there was net immigration of seals from outside of the national population; and (iv) colony-specific bycatch rates were applied to assess the relative vulnerability of the major grey seal breeding colonies to bycatch mortality. Results demonstrated that (i) higher levels of bycatch reduced population growth, with bycatch of 800 seals per year reducing the national population by 99% over 100 years; (ii) population viability was most sensitive to bycatch mortality of female seals, and more robust to juvenile or male mortality; (iii) recruitment of 500 seals per year prevented population decline despite a worst-case bycatch scenario of 800 seals bycaught per year; (iv) colonies in the south and southwest were the first to show signs of decline under increasing bycatch pressure. PVA provides a clear justification for improved monitoring of seal bycatch to obtain more precise bycatch estimates, and highlights the need for future studies to identify appropriate grey seal management units

Comparison of SEER Treatment Data With Medicare Claims

The population-based Surveillance, Epidemiology, and End Results (SEER) registries collect information on first-course treatment, including surgery, chemotherapy, radiation therapy, and hormone therapy. However, the SEER program does not release data on chemotherapy or hormone therapy due to uncertainties regarding data completeness. Activities are ongoing to investigate the opportunity to supplement SEER treatment data with other data sources

Beyond the conference: Singing our SSONG

The International Society for the Scholarship of Teaching and Learning (ISSOTL) annual conference presents an exciting opportunity to meet with international colleagues from diverse backgrounds and situations to commune on our common interest in the Scholarship of Teaching and Learning (SoTL). As with every ISSOTL conference, the enthusiasm for SoTL was palpable in Los Angeles in 2016. Rich discussions took place, networks were formed, and promises to keep in touch were made. Unfortunately, previous conference experiences have taught us that these good intentions often fall short once the conference bubble has burst and the reality of daily life sets in once more. In an attempt to circumvent this phenomenon, we—seven colleagues from three different countries—embarked on a research project that enabled us to maintain the relationships and fruitful discussions we had initiated at ISSOTL16. We established Small, Significant Online Network Group, or SSONG, inspired by a conference workshop on small significant networks. As a group, we met regularly online using Adobe Connect© and engaged in significant conversations around SoTL that were private, trustful, and intellectually intriguing. This article reflects our experiences in establishing and maintaining the group. We discuss how the group was formed; its alignment with the concept of small, significant networks; and the benefits and challenges we encountered. Four key principles of the group that have emerged will also be discussed in detail, enabling readers to consider how they could adapt the concept for their own purposes

A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

Adenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this post-translational modification during early vertebrate development.https://doi.org/10.1186/s12864-019-5773-