645 research outputs found
Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes
Evaluation of molecularly imprinted polymers for selective extraction of methotrexate from human plasma prior to its LC determination
Development and validation of an LC method for the determination of six corticosteroids, salicylic acid and parabens in different pharmaceutical formulations
peer reviewedaudience: researcher, professional, student, popularizationMise au point de méthodes d’analyse en vue de l’étude de stabilité des principes actifs dans des formes dermopharmaceutiques dans le cadre de l’établissement d’un Nouveau Formulaire Thérapeutique valid
Développement d’une méthode de dosage automatisé du méthotrexate dans le plasma humain par couplage direct à la chromatographie liquide de l’extraction sur phase solide à empreintes moléculaires
Peer reviewe
Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis
PPERFORMANCE EVALUATION OF TWO MIPS FOR THE SPE-LC-UV DETERMINATION OF p-[18F]MPPF IN PLASMA
FP6 STRP 516984 MI-lab-on-chi
Separation of aminoglutethimide enantiomers using single and dual cyclodextrin system in capillary electrophoresis
peer reviewedaudience: researcher, professional, student, popularizatio
Automated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography
A fully automated liquid chromatographic method was developed for the determination of Ro 28-2653, a new synthetic inhibitor of matrix metalloproteinases (MMPs), in ovine serum and plasma. The method was based on the coupling of a pre-column packed with restricted access material, namely LiChrospher RP-8 ADS (alkyl diol silica), for sample clean-up to an analytical column containing octyl silica stationary phase. One hundred mul of biological sample, to which 2-propanol was automatically added, were injected onto the ADS pre-column, which was then washed with a washing liquid consisting of a mixture of 25 mM phosphate buffer (pH 7.0) and acetonitrile (90: 10; v/v) for 10 min. By rotation of the switching valve, the analyte was then eluted in the back-flush mode with the LC mobile phase composed of a mixture of acetonitrile and 25 mM phosphate buffer (pH 7.0) (57:43; v/v). The UV detection was performed at 395 nm. The main parameters likely to influence the sample preparation technique were investigated. The method was then validated over a concentration range from 17.5 to 1950 ng/mI, the first concentration level corresponding to the lower limit of quantitation. At this concentration level, the mean bias and the R.S.D. value for intermediate precision were -2.4% and 4.2%, respectively. (C) 2004 Elsevier B.V. All rights reserved
DEVELOPMENT AND VALIDATION OF A METHOD FOR THE LC DETERMINATION p-[18F]MPPF IN PLASMA USING A MISPE
Peer reviewe
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