Heat Transfer Correlations for compressible flow in Micro Heat Exchangers

The paper discusses the definition of dimensionless parameters useful to define a local correlation for convective heat transfer in compressible, micro scale gaseous flows. A combination of static and stagnation temperatures is chosen, as it allows to weight the temperature change related to the heat transfer and that induced by conversion of internal energy into kinetic one. The correlation offers a purely convective local Nusselt number, i.e. correlating the heat flow rate with the local flow parameters and wall surface temperature. The correlation is validated through a series of numerical computations in both counter-current and co-current micro heat exchanger configurations. The numerical computations take into account rarefaction and conjugate heat transfer effects

Surface roughness effect on ultracold neutron interaction with a wall and implications for computer simulations

We review the diffuse scattering and the loss coefficient in ultracold neutron reflection from slightly rough surfaces, report a surprising reduction in loss coefficient due to roughness, and discuss the possibility of transition from quantum treatment to ray optics. The results are used in a computer simulation of neutron storage in a recent neutron lifetime experiment that re-ported a large discrepancy of neutron lifetime with the current particle data value. Our partial re-analysis suggests the possibility of systematic effects that were not included in this publication.Comment: 39 pages, 9 figures; additional calculations include

Validating a method for the estimate of gait spatio-temporal parameters with IMUs data on healthy and impaired people from two clinical centers

Instrumented gait analysis offers objective clinical outcome assessment. To this purpose, inertial measurement units (IMUs) represent nowadays a very effective solution due to their limited cost, ease of use and improved wearability. The aim of this study was to apply a well-documented IMU-based method to measure gait spatio-temporal parameters in a large number of healthy and gait-impaired subjects, and evaluate its robustness and validity across two clinical centers. Overall, the results of this work represent a robust and reliable foundation for the clinical use of the proposed IMU based method for gait parameters estimation

Eventos: ferramentas estratégicas de comunicação.

A Comunicação Organizacional na Empresa Brasileira de Pesquisa Agropecuária (Embrapa) é definida, em sua política, como um processo gerencial permanente e sistêmico, que integra as atividades de relacionamento entre organização e públicos, tendo como objetivo criar e manter os fluxos de informação. Nesse contexto a promoção e realização de eventos é uma das ferramentas de comunicação usadas estrategicamente com o objetivo de criar e reforçar relacionamentos entre empresa e públicos de interesse, bem como apoiar o processo de transferência de tecnologia na Embrapa

From Natural Woods to High Density Materials: An Ecofriendly Approach

Densified wood are a woody materials which an increase in density and mechanical properties. The materials obtained in this work, using less pollutant reagents, showed an increase in density from 200% to 400%. The characterizations determine the chemical and structural change compositions after every step. These characterizations showed how different woods have comparable densities and final mechanical properties (+300% the initial one) after densification process

Romano, Santi

Santi Romano was born in Palermo, Sicily on January 31, 1875. His origins had a notable impact on his legal training, as Palermo was the cradle of a host of renewed legal studies that changed once and for all the way of approaching public law in Italy. His teacher, Vittorio Emanuele Orlando, was both a leading statesman and an innovator of the notion and practice of public and administrative law. The young Romano contributed to a seminal collection of volumes, edited by Orlando, devoted to Italian administrative law, Primo trattato completo di diritto amministrativo italiano (First Complete Treatise on Italian Administrative Law), published between 1900 and 1915. The importance Orlando and his many collaborators attached to such a monumental scholarly enterprise should not go unnoticed: in his preface to the first volume, Orlando emphasized his and the other contributors’ conscious, and eventually successful, attempt at constructing an Italian school of public law. This collection of writings, he claimed, was the necessary counterpoint to the growing expansion of the state’s competences in the public realm. While in the past, Italian scholars had been heavily influenced by the French lawyers who had been working and mulling over the Code Napoléon and, subsequently, by the German pandectists, Orlando insisted that the specialization and evolution of the Italian state called for a full-fledged “homegrown” scholarly apparatus. After obtaining his degree at the University of Palermo, Romano wholeheartedly adhered to this ambitious project

Cyclic Pitch Control for the Reduction of Ultimate Loads on Wind Turbines

In this paper we study the use of individual blade pitch control as a way to reduce ultimate loads. This load alleviation strategy exploits the fact that cyclic pitching of the blades induces in general a reduction of the average loading of a wind turbine, at least for some components as the main bearing, the yaw bearing, or the tower. When ultimate loads are generated during shutdowns, the effect of the use of cyclic pitch results in reduced peak loads. In fact, as the machine starts from a less stressed condition, the response to an extreme gust or other event will result in reduced loading on its components. This form of load mitigation can be seen as a preventative load mitigation strategy: the effect on load reduction is obtained without the need to detect and react to an extreme event, but by simply unloading the machine so that, in case an extreme event happens, the result will be less severe. The effect of peak load mitigation by preventative cyclic pitch is investigated with reference to a multi-MW wind turbine, by using high-fidelity aeroelastic simulations in a variety of operating conditions

Extension of the rigid‐constraint method for the heuristic suboptimal parameter tuning to ten sensor fusion algorithms using inertial and magnetic sensing

The orientation of a magneto‐inertial measurement unit can be estimated using a sensor fusion algorithm (SFA). However, orientation accuracy is greatly affected by the choice of the SFA parameter values which represents one of the most critical steps. A commonly adopted approach is to fine‐tune parameter values to minimize the difference between estimated and true orientation. However, this can only be implemented within the laboratory setting by requiring the use of a concurrent gold‐standard technology. To overcome this limitation, a Rigid‐Constraint Method (RCM) was proposed to estimate suboptimal parameter values without relying on any orientation reference. The RCM method effectiveness was successfully tested on a single‐parameter SFA, with an average error increase with respect to the optimal of 1.5 deg. In this work, the applicability of the RCM was evaluated on 10 popular SFAs with multiple parameters under different experimental scenarios. The average residual between the optimal and suboptimal errors amounted to 0.6 deg with a maximum of 3.7 deg. These encouraging results suggest the possibility to properly tune a generic SFA on different scenarios without using any reference. The synchronized dataset also including the optical data and the SFA codes are available online

Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells

Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas (NB-MSCs) to define interactions with the tumor microenvironment. Methods: Specimens were obtained from 7 pediatric patients diagnosed with neuroblastoma (NB). Morphology, immunophenotype, differentiation capacity, proliferative growth, expression of stemness and neural differentiation markers were evaluated. Moreover, the ability of cells to modulate the immune response, i.e. inhibition of phytohemagglutinin (PHA) activated peripheral blood mononuclear cells (PBMCs) and natural killer (NK) cytotoxic function, was examined. Gene expression profiles, known to be related to tumor cell stemness, Wnt pathway activation, epithelial-mesenchymal transition (EMT) and tumor metastasis were also evaluated. Healthy donor bone marrow-derived MSCs (BM-MSC) were employed as controls. Results: NB-MSCs presented the typical MSC morphology and phenotype. They showed a proliferative capacity superimposable to BM-MSCs. Stemness marker expression (Sox2, Nanog, Oct3/4) was comparable to BM-MSCs. NB-MSC in vitro osteogenic and chondrogenic differentiation was similar to BM-MSCs, but NB-MSCs lacked adipogenic differentiation capacity. NB-MSCs reached senescence phases at a median passage of P7 (range, P5-P13). NB-MSCs exhibited greater immunosuppressive capacity on activated T lymphocytes at a 1:2 (MSC: PBMC) ratio compared with BM-MSCs (p = 0.018). NK cytotoxic activity was not influenced by co-culture, either with BM-MSCs or NB-MSCs. Flow-cytometry cell cycle analysis showed that NB-MSCs had an increased number of cells in the G0-G1 phase compared to BM-MSCs. Transcriptomic profiling results indicated that NB-MSCs were enriched with EMT genes compared to BM-MSCs. Conclusions: We characterized the biological features, the immunomodulatory capacity and the gene expression profile of NB-MSCs. The NB-MSC gene expression profile and their functional properties suggest a potential role in promoting tumor escape, invasiveness and metastatic traits of NB cancer cells. A better understanding of the complex mechanisms underlying the interactions between NB cells and NB-derived MSCs should shed new light on potential novel therapeutic approaches