[Duo fratres consagnuinei. Anna, & Christoforus Despuig, possessione> opidorum Alcantere Benexidas, et Rafol, coram Regio Senatu Valentino petierunt... ] [Texto impreso]

Ejemplar falto de portadaTitulo tomado de comienzo de texto en sign. A2Texto fechado en Valencia, 1608Sign.: A-D6, E

Por la villa de Gandia con los acreedores censalistas [Texto impreso] : ... por quenta de los Duques señores de aquel Estado.

En v. de h. 5 consta la fecha de 1609Port. con grab. xi

Hydromorphological control of phosphorus in a large free-flowing gravel bed river: the Garonne river (France)

The objective of this paper is to relate phosphorus (P) transport dynamics and hydromorphological characteristics of a large human-influenced river, the River Garonne within a sector receiving the waste water of a sewage treatment plant for a population of 600 000. Two studies were conducted in 1997 and 1999 during two different hydrological conditions at low-flow periods. The 1997 study was carried out on an 18-km stretch with discharges varying between 33 and 53 m3/s and with very small fluctuations. The 1999 study concerned a longer stretch of 47 km, divided into four smaller reaches, and with discharges fluctuating rapidly from 40 to 108 m3/s. Downstream of the sewage treatment plant, total phosphorus (TP) concentrations ranged from 0.19 to 0.27 mg/L and were mainly in the dissolved form: between 60 and 78% of TP was dissolved reactive phosphorus (DRP). P concentrations were significantly lower upstream of the sewage treatment plant. By a mass-balance approach, we estimated that the sewage treatment plant represents more than half the input (between 59 and 67%) of the studied sector. TP dynamic is linked to suspended solids for discharges above 60 m3/s. During established low-flow period in the 1997 study (<60 m3/s), 22 and 27% of TP and DRP were retained by the river bed. In the 1999 study, under different low-water period hydraulic conditions, we calculate that particulate P retention occurred in two reaches among the four under study and only for discharges below 60 m3/s. We show that for established discharges below 60 m3/s, there is an active uptake of transported P by functional compartments (i.e. the hyporheic zone and the periphyton). During the low-water period with relatively high hydraulic fluctuations, and for discharges >60 m3/s, P retention is controlled as expected by suspended matter dynamics

Current Therapeutic Approaches from Imidazoline and Opioid Receptors Modulators in Neuroprotection

Due to brain plasticity, the nervous system is capable of manifesting behavioral variations, adapted to the influences from both external and internal environment. Multiple neurotransmitters are involved in the mediation of pathological processes at the molecular, cellular, regional, and interregional levels participating in cerebral plasticity, their intervention being responsible for various structural, functional, and behavioral disturbances. The current therapeutic strategies in neuroprotection aim at blocking on different levels, the molecular cascades of the pathophysiological mechanisms responsible for neuronal dysfunctions and ultimately for neuronal death. Different agents influencing these neurotransmitters have demonstrated beneficial effects in neurogenesis and neuroprotection, proved in experimental animal models of focal and global ischemic injuries. Serotonin, dopamine, glutamate, N-methyl-D-aspartate, and nitric oxide have been shown to play a significant role in modulating nervous system injuries. The imidazoline system is one of the important systems involved in human brain functioning. Experimental investigations have revealed the cytoprotective effects of imidazoline I2 receptor ligands against neuronal injury induced by hypoxia in experimental animals. The neuroprotective effects were also highlighted for kappa and delta receptors, whose agonists demonstrated the ability to reduce architectural lesions and to recover neuronal functions of animals with experimentally induced brain ischemia

New Antidepressant Medication: Benefits Versus Adverse Effects

Depression [major depressive disorder (MDD)] is a mood disturbance of multifactorial origin, associated with high rates of morbidity and mortality, lack of work productivity, adverse health behaviors, and increased healthcare expenses. MDD is a leading cause of suicide, and it affects the prognosis of chronic conditions (heart diseases, diabetes, and cancer, among others). Current pharmacological treatment for MDD covers different classes of drugs, including tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and atypical antidepressants. The aim of this chapter is to review the literature, highlight the side effects of newer antidepressants, and especially point out the most important aspects of the latest agents approved for the treatment of MDD in adults: desvenlafaxine, levomilnacipran, vilazodone, and vortioxetine. Desvenlafaxine is a SNRI and the primary active metabolite of venlafaxine; also a SNRI, levomilnacipran is an enantiomer of the racemate milnacipran. Vilazodone and vortioxetine are multimodal antidepressants, which combine SSRI activity with additional receptor activity. Although they have proven efficacy in treating MDD and are being investigated for other possible indications, further detailed clinical trials are needed to establish their pharmaco-toxicological profile, following prolonged administration in patients who may suffer from various comorbidities

Galois Connections and Data Mining

We investigate the application of Galois connections to the identification of frequent item sets, a central problem in data mining. Starting from the notion of closure generated by a Galois connection, we define the notion of extended closure, and we use these notions to improve the classical Apriori algorithm. Our experimental study shows that in certain situations, the algorithms that we describe outperform the Apriori algorithm. Also, these algorithms scale up linearly. 1 C.S.Calude and G.Stefanescu (eds.). Automata, Logic, and Computability. Special issue dedicated to Professor Sergiu Rudeanu Festschrift