Un programa de Tratamiento de corte Cognitivo-Comportamental basado en las TIC para la prevención y el tratamiento de la depresión: Descripción del programa y datos preliminares

Introducción: En el año 2020 la depresión alcanzará el segundo lugar del ranking de los DALYs (Disability Adjusted Life Years), por ello su prevención es un punto central en el Pacto Europeo para la Salud Mental y el Bienestar. Actualmente, menos del 50 % de las personas afectadas recibe el tratamiento correcto. El uso de internet facilita el acceso a los Tratamientos Basados en la Evidencia. Además, es importante desarrollar programas de prevención. Nuestro grupo ha desarrollado un programa preventivo, de corte cognitivo comportamental, auto-aplicado a través de Internet. Sonreír es Divertido combina los procedimientos eficaces para el manejo del estrés, la regulación emocional, la capacidad de afrontamiento y la resiliencia. Metodología: La muestra está compuesta por nueve participantes varones desempleados. La media de edad es de 36-33 (SD = 10–759), con un rango de 22 a 50 años. Se utilizaron: Escala general de Gravedad e Interferencia de la Ansiedad y de la Depresión, Inventario de Depresión de Beck-II y Escala Multidimensional de Estilos de Afrontamiento. Resultados: No hay diferencias estadísticamente significativas del pre al postratamiento, a excepción de la subescala de Aceptación del Brief Cope (z = –2, 27; p < ,05). En el resto de variables, las medias muestran una tendencia a la mejoría. Conclusión: Este programa puede ser útil como estrategia para la prevención, ya que, a pesar de que los participantes estaban pasando por una situación difícil, se observa una tendencia a la mejoría.In 2020, depression will reach the second place in the DALYs (Disability Adjusted Life Years), ranking, so prevention is a central point for the European Pact for Mental Health and Wellbeing. Currently, less than 50 % of those people affected receive the correct treatment. Using Internet facilitates the access to evidence-based treatments. It is also important to develop prevention programs. Our group has ellaborated a cognitive-behavioural preventive program, self-applied through the Internet. Smiling is Fun combines effective procedures for stress management, emotional regulation, coping ability and resilience. Methodology: The sample consists of nine participants. They are all unemployed men, and their mean age is 36’33 (SD = 10’759), with a range of 22-50 years. We used: Overall Anxiety Severity and Impairment Scale, Overall Depression Severity and Impairment Scale, Beck Depression Inventory II and Brief cope. Results: There aren’t statistically significant differences between pre and post-treatment, except for the Acceptance subscale of the Brief Cope (z = –2, 27, p <.05). For all other variables, means show a tendency to improve. Conclusion: This program can be useful as a prevention strategy considering that even though the participants were going through a difficult situation, there is a trend towards improvement

Efficacy of Three Low-Intensity, Internet-Based Psychological Interventions for the Treatment of Depression in Primary Care: Randomized Controlled Trial

Background: Primary care is a major access point for the initial treatment of depression, but the management of these patients is far from optimal. The lack of time in primary care is one of the major difficulties for the delivery of evidence-based psychotherapy. During the last decade, research has focused on the development of brief psychotherapy and cost-effective internet-based interventions mostly based on cognitive behavioral therapy (CBT). Very little research has focused on alternative methods of treatment for depression using CBT. Thus, there is a need for research into other therapeutic approaches. Objective: This study aimed to assess the effectiveness of 3 low-intensity, internet-based psychological interventions (healthy lifestyle psychoeducational program [HLP], focused program on positive affect promotion [PAPP], and brief intervention based on mindfulness [MP]) compared with a control condition (improved treatment as usual [iTAU]). Methods: A multicenter, 4-arm, parallel randomized controlled trial was conducted between March 2015 and March 2016, with a follow-up of 12 months. In total, 221 adults with mild or moderate major depression were recruited in primary care settings from 3 Spanish regions. Patients were randomly distributed to iTAU (n=57), HLP (n=54), PAPP (n=56), and MP (n=54). All patients received iTAU from their general practitioners. The main outcome was the Spanish version of the Patient Health Questionnaire-9 (PHQ-9) from pretreatment (time 1) to posttreatment (time 2) and up to 6 (time 3) and 12 (time 4) months’ follow-up. Secondary outcomes included the visual analog scale of the EuroQol, the Short-Form Health Survey (SF-12), the Positive and Negative Affect Schedule (PANAS), and the Pemberton Happiness Index (PHI). We conducted regression models to estimate outcome differences along study stages. Results: A moderate decrease was detected in PHQ-9 scores from HLP (β=–3.05; P=.01) and MP (β=–3.00; P=.01) compared with iTAU at posttreatment. There were significant differences between all intervention groups and iTAU in physical SF-12 scores at 6 months after treatment. Regarding well-being, MP and PAPP reported better PHI results than iTAU at 6 months post treatment. PAPP intervention significantly decreased PANAS negative affect scores compared with iTAU 12 months after treatment. Conclusions: The low-intensity, internet-based psychological interventions (HLP and MP) for the treatment of depression in primary care are more effective than iTAU at posttreatment. Moreover, all low-intensity psychological interventions are also effective in improving medium- and long-term quality of life. PAPP is effective for improving health-related quality of life, negative affect, and well-being in patients with depression. Nevertheless, it is important to examine possible reasons that could be implicated for PAPP not being effective in reducing depressive symptomatology; in addition, more research is still needed to assess the cost-effectiveness analysis of these interventions

Plantes ornamentals tòxiques

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Plantes medicinals, etnobotànica i bioprospecció, Curs: 2013-2014, Coordinadors: Carles Benedí i Joan SimonAquesta obra és el resultat de la tasca col·laborativa feta pels estudiants de l’assignatura optativa de l’ensenyament de Farmàcia «Plantes Medicinals, Etnobotànica i Bioprospecció» del curs 2013-2014. El seu contingut se centra en unes monografies didàctiques sobre quinze plantes ornamentals tòxiques, per a les quals es detalla la nomenclatura, l’origen i la distribució geogràfica, la descripció botànica, la toxicitat i la bibliografia utilitzada

Curs 0: preparació per als estudis a l’EEBE

Aquest article presenta el desenvolupament i primers resultats d'ús d'un conjunt de cursos virtuals que pretenen proporcionar uns coneixements inicials bàsics de Matemàtiques, Física i !ímica als estudiants que accedeixen a estudis de grau a l'Escola d'Enginyeria de Barcelona Est (EEBE). Els cursos han estat desenvolupats sobre la plataforma Atenea (Moodle). El seu nucli el constitueixen un conjunt de materials per a autoaprenentatge que inclouen documents escrits, vídeos i tests d'autoavaluació. Els documents escrits i els vídeos corresponen tant a explicacions de teoria com a la resolució detallada d'exercicis. En el marc d'una prova pilot, els cursos, de seguiment voluntari durant el període transcorregut entre la matricula (mitjans de juliol) i l'inici de les classes (mitjans de setembre), van ser publicitats a tots els estudiants de nou accés del curs 2021-2022. Encara que la participació va ser més limitada del que s'esperava (únicament el 22% dels estudiants de nou accés es van inscriure), cal destacar que els estudiants que sí que van seguir els cursos van expressar majoritàriament una bona valoració dels mateixos (al respondre un qüestionari de satisfacció). Del desenvolupament dels cursos i de la realització de la prova pilot s'han obtingut unes quantes conclusions que també queden reflectides al final de l'article

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

TFG 2012/2013

Amb aquesta publicació, EINA, Centre universitari de Disseny i Art adscrit a la Universitat Autònoma de Barcelona, dóna a conèixer el recull dels Treballs de Fi de Grau presentats durant el curs 2012-2013. Voldríem que un recull com aquest donés una idea més precisa de la tasca que es realitza a EINA per tal de formar nous dissenyadors amb capacitat de respondre professionalment i intel·lectualment a les necessitats i exigències de la nostra societat. El treball formatiu s’orienta a oferir resultats que responguin tant a paràmetres de rigor acadèmic i capacitat d’anàlisi del context com a l’experimentació i la creació de nous llenguatges, tot fomentant el potencial innovador del disseny.Con esta publicación, EINA, Centro universitario de diseño y arte adscrito a la Universidad Autónoma de Barcelona, da a conocer la recopilación de los Trabajos de Fin de Grado presentados durante el curso 2012-2013. Querríamos que una recopilación como ésta diera una idea más precisa del trabajo que se realiza en EINA para formar nuevos diseñadores con capacidad de responder profesional e intelectualmente a las necesidades y exigencias de nuestra sociedad. El trabajo formativo se orienta a ofrecer resultados que respondan tanto a parámetros de rigor académico y capacidad de análisis, como a la experimentación y la creación de nuevos lenguajes, al tiempo que se fomenta el potencial innovador del diseño.With this publication, EINA, University School of Design and Art, ascribed to the Autonomous University of Barcelona, brings to the public eye the Final Degree Projects presented during the 2012-2013 academic year. Our hope is that this volume might offer a more precise idea of the task performed by EINA in training new designers, able to speak both professionally and intellectually to the needs and demands of our society. The educational task is oriented towards results that might respond to the parameters of academic rigour and the capacity for contextual analysis, as well as to considerations of experimentation and the creation of new languages, all the while reinforcing design’s innovative potential

Patients with Thyroid Dyshormonogenesis and DUOX2 Variants: Molecular and Clinical Description and Genotype–Phenotype Correlation

Congenital hypothyroidism; Phenotypic variability; Thyroid dyshormonogenesisHipotiroidismo congénito; Variabilidad fenotípica; Dishormonogénesis tiroideaHipotiroïdisme congènit; Variabilitat fenotípica; Dishormonogènesi tiroideaThyroid dyshormonogenesis (THD) is a heterogeneous group of genetic diseases caused by the total or partial defect in the synthesis or secretion of thyroid hormones. Genetic variants in DUOX2 can cause partial to total iodination organification defects and clinical heterogeneity, from transient to permanent congenital hypothyroidism. The aim of this study was to undertake a molecular characterization and genotype–phenotype correlation in patients with THD and candidate variants in DUOX2. A total of 31 (19.38%) patients from the Catalan Neonatal Screening Program presented with variants in DUOX2 that could explain their phenotype. Fifteen (48.39%) patients were compound heterozygous, 10 (32.26%) heterozygous, and 4 (12.90%) homozygous. In addition, 8 (26.67%) of these patients presented variants in other genes. A total of 35 variants were described, 10 (28.57%) of these variants have not been previously reported in literature. The most frequent variant in our cohort was c.2895_2898del/p.(Phe966SerfsTer29), classified as pathogenic according to reported functional studies. The final diagnosis of this cohort was permanent THD in 21 patients and transient THD in 10, according to reevaluation and/or need for treatment with levothyroxine. A clear genotype–phenotype correlation could not be identified; therefore, functional studies are necessary to confirm the pathogenicity of the variants.This work was supported by the Instituto de Salud Carlos III (Madrid, Spain) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, U-712 to N.B.-R. and M.F.-C.)