Transapical off-pump mitral valve repair with Neochord Implantation (TOP-MINI): step-by-step guide

open10openColli, Andrea; Zucchetta, Fabio; Torregrossa, Gianluca; Manzan, Erica; Bizzotto, Eleonora; Besola, Laura; Bellu, Roberto; Sarais, Cristiano; Pittarello, Demetrio; Gerosa, GinoColli, Andrea; Zucchetta, Fabio; Torregrossa, Gianluca; Manzan, Erica; Bizzotto, Eleonora; Besola, Laura; Bellu, Roberto; Sarais, Cristiano; Pittarello, Demetrio; Gerosa, Gin

Non-viral approaches to gene therapy

Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses. In addition, investigators have demonstrated that direct application of DNA via injection or particle bombardment can be used for vaccination. Analysis of the mechanisms employed by viruses to invade cells has demonstrated a crucial role for membrane-active proteins or peptides in the entry process. Several non-viral systems that include membrane-active elements are now available

Probing the order parameter symmetry in the cuprate high temperature superconductors by SQUID microscopy

The orbital component of the order parameter in the cuprate high-Tc cuprate superconductors is now well established, in large part because of phase sensitive tests. Although it would be desirable to use such tests on other unconventional superconductors, there are a number of favorable factors associated with the properties of the cuprates, and a number of technical advances, that were required for these tests to be successful. In this review I will describe the development of phase sensitive pairing symmetry tests using SQUID microscopy, underlining the factors favoring these experiments in the cuprates and the technical advances that had to be made.Comment: 12 pages, 7 figure, invited review to be published in Comptes Rendus de l'Academie des Sciences (Comptes Rendus Physique

An original framework for understanding human actions and body language by using deep neural networks

The evolution of both fields of Computer Vision (CV) and Artificial Neural Networks (ANNs) has allowed the development of efficient automatic systems for the analysis of people's behaviour. By studying hand movements it is possible to recognize gestures, often used by people to communicate information in a non-verbal way. These gestures can also be used to control or interact with devices without physically touching them. In particular, sign language and semaphoric hand gestures are the two foremost areas of interest due to their importance in Human-Human Communication (HHC) and Human-Computer Interaction (HCI), respectively. While the processing of body movements play a key role in the action recognition and affective computing fields. The former is essential to understand how people act in an environment, while the latter tries to interpret people's emotions based on their poses and movements; both are essential tasks in many computer vision applications, including event recognition, and video surveillance. In this Ph.D. thesis, an original framework for understanding Actions and body language is presented. The framework is composed of three main modules: in the first one, a Long Short Term Memory Recurrent Neural Networks (LSTM-RNNs) based method for the Recognition of Sign Language and Semaphoric Hand Gestures is proposed; the second module presents a solution based on 2D skeleton and two-branch stacked LSTM-RNNs for action recognition in video sequences; finally, in the last module, a solution for basic non-acted emotion recognition by using 3D skeleton and Deep Neural Networks (DNNs) is provided. The performances of RNN-LSTMs are explored in depth, due to their ability to model the long term contextual information of temporal sequences, making them suitable for analysing body movements. All the modules were tested by using challenging datasets, well known in the state of the art, showing remarkable results compared to the current literature methods

Modeling of the transient interstitial diffusion of implanted atoms during low-temperature annealing of silicon substrates

It has been shown that many of the phenomena related to the formation of "tails" in the low-concentration region of ion-implanted impurity distribution are due to the anomalous diffusion of nonequilibrium impurity interstitials. These phenomena include boron implantation in preamorphized silicon, a "hot" implantation of indium ions, annealing of ion-implanted layers et cetera. In particular, to verify this microscopic mechanism, a simulation of boron redistribution during low-temperature annealing of ion-implanted layers has been carried out under different conditions of transient enhanced diffusion suppression. Due to the good agreement with the experimental data, the values of the average migration length of nonequilibrium impurity interstitials have been obtained. It has been shown that for boron implanted into a silicon layer preamorphized by germanium ions the average migration length of impurity interstitials at the annealing temperature of 800 Celsius degrees be reduced from 11 nm to approximately 6 nm due to additional implantation of nitrogen. The further shortening of the average migration length is observed if the processing temperature is reduced to 750 Celsius degrees. It is also found that for implantation of BF2 ions into silicon crystal, the value of the average migration length of boron interstitials is equal to 7.2 nm for thermal treatment at a temperature of 800 Celsius degrees.Comment: 10 pages, 6 figures, RevTe

Branch-entangled polariton pairs in planar microcavities and photonic wires

A scheme is proposed for the generation of branch-entangled pairs of microcavity polaritons through spontaneous inter-branch parametric scattering. Branch-entanglement is achievable when there are two twin processes, where the role of signal and idler can be exchanged between two different polariton branches. Branch-entanglement of polariton pairs can lead to the emission of frequency-entangled photon pairs out of the microcavity. In planar microcavities, the necessary phase-matching conditions are fulfilled for pumping of the upper polariton branch at an arbitrary in-plane wave-vector. The important role of nonlinear losses due to pair scattering into high-momentum exciton states is evaluated. The results show that the lack of protection of the pump polaritons in the upper branch is critical. In photonic wires, branch-entanglement of one-dimensional polaritons is achievable when the pump excites a lower polariton sub-branch at normal incidence, providing protection from the exciton reservoir.Comment: Under review at PR

On the many saddle points description of quantum black holes

Considering two dimensional gravity coupled to a CFT, we show that a semiclassical black hole can be described in terms of two Liouville theories matched at the horizon. The black hole exterior corresponds to a space-like while the interior to a time-like Liouville theory. This matching automatically implies that a semiclassical black hole has an infinite entropy. The path integral description of the time-like Liouville theory (the Black Hole interior) is studied and it is found that the correlation functions of the coupled CFT-gravity system are dominated by two (complex) saddle points, even in the semiclassical limit. We argue that this system can be interpreted as two interacting Bose-Einstein condensates constructed out of two degenerate quantum states. In AdS/CFT context, the same system is mapped into two interacting strings intersecting inside a three-dimensional BTZ black hole. Finally, we discuss why, beyond the semiclassical approximation, we expect no firewalls appearing in our system.Comment: 11 pages, RevTeX; v2 clarifications and references adde