4 research outputs found
Bibliography of secondary sources on the history of dermatology III. Books, monographs, and chapters in English supplemented through 2005.
Providing supplements to the history of dermatology bibliographic record has been a continuous project for the past four decades. When the endeavor was initiated, the original authors decided that only contributions in English and those directly related to dermatology, excluding sexually transmitted diseases as such, would be indexed.
There is the perennial question of whether such a manually created bibiliographic project has a need. The obvious answer remains yes. While Index Medicus has expanded the number of journals that are indexed, the number of dermatology publications currently included by Index Medicus is just over fifty. Granted, most of the papers of dermatologic interest are included in these journals, some contributions are to be found in non-indexed publications. In addition, many documents of an historical interest or of a biographical nature are not necessarily selected for indexing in Index Medicus.
These installments are the first since 1980 for which the late John Thorne Crissey (1924-2009) has not contributed. His knowledge of the history of dermatology and his intellectual support are greatly missed
Bibliography of Secondary Sources on the History of Dermatology II. Obituaries and Biographies in English before 1973
Bibliography of Secondary Sources on the History of Dermatology
II. Obituaries and Biographies in English before 197
Divergent role of nitric oxide in insulinâstimulated aortic vasorelaxation between lowâ and highâintrinsic aerobic capacity rats
Lowâintrinsic aerobic capacity is associated with increased risk for cardiovascular and metabolic diseases and is a strong predictor of early mortality. The effects of intrinsic aerobic capacity on the vascular response to insulin are largely unknown. We tested the hypothesis that rats selectively bred for a low capacity to run (LCR) exhibit vascular dysfunction and impaired vascular reactivity to insulin compared to high capacity running (HCR) rats. Mature female LCR (n = 21) and HCR (n = 17) rats were maintained under sedentary conditions, and in vitro thoracic aortic vascular function was assessed. LCR exhibited greater body mass (13%), body fat (35%), and subcutaneous, perigonadal, and retroperitoneal adipose tissue mass, than HCR. During an intraperitoneal glucose tolerance test, glucose area under the curve (AUC) was not different but insulin AUC was 2âfold greater in LCR than HCR. Acetylcholine and insulinâstimulated aortic vasorelaxation was significantly greater in LCR (65.2 ± 3.8%, and 32.7 ± 4.1%) than HCR (55.0 ± 3.3%, and 16.7 ± 2.8%). Inhibition of nitric oxide synthase (NOS) with LâNAME entirely abolished insulinâmediated vasorelaxation in the aorta of LCR, with no effect in HCR. LCR rats exhibited greater expression of Insulin Receptor protein, lower Endothelin ReceptorâA protein, a downâregulation of transcripts for markers of immune cell infiltration (CD11C, CD4, and F4/80) and upâregulation of proâatherogenic inflammatory genes (VCAMâ1 and MCPâ1) in the aorta wall. Contrary to our hypothesis, lowâaerobic capacity was associated with enhanced aortic endothelial function and NOâmediated reactivity to insulin, despite increased adiposity and evidence of whole body insulin resistance.Rats selectively bred for lowâaerobic capacity displayed enhanced aortic endothelial function and nitric oxideâmediated insulinâstimulated vasorelaxation, despite increased adiposity and evidence of whole body insulin resistance. The vascular reactivity to insulin in highâintrinsic aerobic capacity rats was independent of nitric oxide. Our findings demonstrate that endothelial and nitric oxide insulinâmediated vasomotor function in the rat aorta is not always associated with aerobic capacity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112223/1/phy212459.pd