20 research outputs found
Knotted vs. Unknotted Proteins: Evidence of Knot-Promoting Loops
- Author
- AE Eriksson
- AL Mallam
- AL Mallam
- AL Mallam
- AL Mallam
- AV Vologodskii
- B Marcone
- C Das
- C Micheletti
- C Micheletti
- C Micheletti
- CA Orengo
- CC Adams
- CM Spahn
- Cristian Micheletti
- D Bölinger
- D Marenduzzo
- D Saadat
- D Shi
- DW Sumners
- E Orlandini
- EC Webb
- EJ Janse van Rensburg
- G Kolesov
- GM Crippen
- Henri Orland
- HL Frisch
- HM Berman
- II Mathews
- J Kyte
- J Michels
- JD Thompson
- JI Sulkowska
- JI Sulkowska
- JI Sulkowska
- JM Mato
- JW Schmidberger
- K Millet
- KI Varughese
- L Xie
- M Delbruck
- ML Mansfield
- N Saitou
- NP King
- P Virnau
- Raffaello Potestio
- RC Lua
- Ruth Nussinov
- S Mika
- S Misaghi
- S Wallin
- SF Altschul
- T Bornschlögl
- V Biou
- VM Levdikov
- VV Rybenkov
- W Humphrey
- WR Taylor
- WR Taylor
- X Yang
- YL Lai
- Z Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2010
- Field of study
Knotted proteins, because of their ability to fold reversibly in the same topologically entangled conformation, are the object of an increasing number of experimental and theoretical studies. The aim of the present investigation is to assess, on the basis of presently available structural data, the extent to which knotted proteins are isolated instances in sequence or structure space, and to use comparative schemes to understand whether specific protein segments can be associated to the occurrence of a knot in the native state. A significant sequence homology is found among a sizeable group of knotted and unknotted proteins. In this family, knotted members occupy a primary sub-branch of the phylogenetic tree and differ from unknotted ones only by additional loop segments. These "knot-promoting" loops, whose virtual bridging eliminates the knot, are found in various types of knotted proteins. Valuable insight into how knots form, or are encoded, in proteins could be obtained by targeting these regions in future computational studies or excision experiments
Lawson criterion for ignition exceeded in an inertial fusion experiment
- Author
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- Zimmerman GB
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Advances and Perspectives of the use of the entomopathogenic fungi beauveria bassiana and metarhizium anisopliae for the control of arthropod pests in poultry production
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ICU Resource Allocation in the New Millennium: Will We Say “No”?
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Nursing management of extradural haematoma
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T HE C ALIFORNIA 500: M EDICAL C ARE AT A NASCAR W INSTON C UP R ACE
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- 'Informa UK Limited'
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Estimating viability of plant protoplasts using double and single staining
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- 'Springer Science and Business Media LLC'
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- Field of study
Aging as a predictor of nursing workload in Intensive Care Unit: results from a Brazilian Sample
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The lesser mealworm Alphitobius diaperinus
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- 'Wiley'
- Publication date
- Field of study