Intelligent search for distributed information sources using heterogeneous neural networks

As the number and diversity of distributed information sources on the Internet exponentially increase, various search services are developed to help the users to locate relevant information. But they still exist some drawbacks such as the difficulty of mathematically modeling retrieval process, the lack of adaptivity and the indiscrimination of search. This paper shows how heteroge-neous neural networks can be used in the design of an intelligent distributed in-formation retrieval (DIR) system. In particular, three typical neural network models - Kohoren's SOFM Network, Hopfield Network, and Feed Forward Network with Back Propagation algorithm are introduced to overcome the above drawbacks in current research of DIR by using their unique properties. This preliminary investigation suggests that Neural Networks are useful tools for intelligent search for distributed information sources

A multi-layered Bayesian network model for structured document retrieval

New standards in document representation, like for example SGML, XML, and MPEG-7, compel Information Retrieval to design and implement models and tools to index, retrieve and present documents according to the given document structure. The paper presents the design of an Information Retrieval system for multimedia structured documents, like for example journal articles, e-books, and MPEG-7 videos. The system is based on Bayesian Networks, since this class of mathematical models enable to represent and quantify the relations between the structural components of the document. Some preliminary results on the system implementation are also presented

Methane activation and exchange by titanium-carbon multiple bonds

We demonstrate that a titanium-carbon multiple bond, specifically an alkylidyne ligand in the transient complex, (PNP)Ti≡C^(t)Bu (A) (PNP^− = N[2-P(CHMe_2)_(2)-4-methylphenyl]_2), can cleanly activate methane at room temperature with moderately elevated pressures to form (PNP)Ti=CHtBu(CH_3). Isotopic labeling and theoretical studies suggest that the alkylidene and methyl hydrogens exchange, either via tautomerization invoking a methylidene complex, (PNP)Ti=CH_(2)(CH_(2)^(t)Bu), or by forming the methane adduct (PNP)Ti≡C^(t)Bu(CH_4). The thermal, fluxional and chemical behavior of (PNP)Ti=CH^(t)Bu(CH_3) is also presented in this study

Atomistic to Circuit Level Modeling of Defective Doped SWCNTs with Contacts for On-Chip Interconnect Application

Carbon nanotubes (CNTs) due to their high electrical/thermal conductivity, high ampacity, high tolerance to electro-migration [1] and small dimensions make them an ideal candidate for future on-chip interconnects [2]. Fabricating the CNTs, random chirality and some defects are introduced which can degrade the CNT electrical properties [3]. Additionally, the contact resistance between metal and CNT presents additional parasitics that impose restraints on the electron transport. Electrical models of CNT for interconnect application were developed several years ago [4-5]. In this paper, we explored on doped and defective single-wall CNTs (SWCNT (24,0)) including contact resistance as important physical parameters to assess the performance of fabricated SWCNTs realistically for back-end-of-line (BEOL) on-chip interconnects on VLSI circuit application

When the Earth trembles in the americas: the experience of haiti and chile 2010.

The response of the nephrological community to the Haiti and Chile earthquakes which occurred in the first months of 2010 is described. In Haiti, renal support was organized by the Renal Disaster Relief Task Force (RDRTF) of the International Society of Nephrology (ISN) in close collaboration with Médecins Sans Frontières (MSF), and covered both patients with acute kidney injury (AKI) and patients with chronic kidney disease (CKD). The majority of AKI patients (19/27) suffered from crush syndrome and recovered their kidney function. The remaining 8 patients with AKI showed acute-to-chronic renal failure with very low recovery rates. The intervention of the RDRTF-ISN involved 25 volunteers of 9 nationalities, lasted exactly 2 months, and was characterized by major organizational difficulties and problems to create awareness among other rescue teams regarding the availability of dialysis possibilities. Part of the Haitian patients with AKI reached the Dominican Republic (DR) and received their therapy there. The nephrological community in the DR was able to cope with this extra patient load. In both Haiti and the DR, dialysis treatment was able to be prevented in at least 40 patients by screening and adequate fluid administration. Since laboratory facilities were destroyed in Port-au-Prince and were thus lacking during the first weeks of the intervention, the use from the very beginning on of a point-of-care device (i-STAT®) was very efficient for the detection of aberrant kidney function and electrolyte parameters. In Chile, nephrological problems were essentially related to difficulties delivering dialysis treatment to CKD patients, due to the damage to several units. This necessitated the reallocation of patients and the adaptation of their schedules. The problems could be handled by the local nephrologists. These observations illustrate that local and international preparedness might be life-saving if renal problems occur in earthquake circumstances

StarHorse: A Bayesian tool for determining stellar masses, ages, distances, and extinctions for field stars

Understanding the formation and evolution of our Galaxy requires accurate distances, ages and chemistry for large populations of field stars. Here we present several updates to our spectro-photometric distance code, that can now also be used to estimate ages, masses, and extinctions for individual stars. Given a set of measured spectro-photometric parameters, we calculate the posterior probability distribution over a given grid of stellar evolutionary models, using flexible Galactic stellar-population priors. The code (called {\tt StarHorse}) can acommodate different observational datasets, prior options, partially missing data, and the inclusion of parallax information into the estimated probabilities. We validate the code using a variety of simulated stars as well as real stars with parameters determined from asteroseismology, eclipsing binaries, and isochrone fits to star clusters. Our main goal in this validation process is to test the applicability of the code to field stars with known {\it Gaia}-like parallaxes. The typical internal precision (obtained from realistic simulations of an APOGEE+Gaia-like sample) are $\simeq 8\%$ in distance, $\simeq 20\%$ in age,$\simeq 6\$ in mass, and $\simeq 0.04$ mag in $A_V$. The median external precision (derived from comparisons with earlier work for real stars) varies with the sample used, but lies in the range of $\simeq [0,2]\%$ for distances, $\simeq [12,31]\%$ for ages, $\simeq [4,12]\%$ for masses, and $\simeq 0.07$ mag for $A_V$. We provide StarHorse distances and extinctions for the APOGEE DR14, RAVE DR5, GES DR3 and GALAH DR1 catalogues.Comment: 21 pages, 12 figures, accepte

Toxidez por alumínio e a seleção de plantas tolerantes com base na expressão fenotípica.

bitstream/CPACT-2010/12324/1/documento-265.pd

The fall and rise of group B Streptococcus in dairy cattle: reintroduction due to human-to-cattle host jumps?

Group B Streptococcus (GBS; Streptococcus agalactiae ) is a major neonatal and opportunistic bacterial pathogen of humans and an important cause of mastitis in dairy cattle with significant impacts on food security. Following the introduction of mastitis control programmes in the 1950s, GBS was nearly eradicated from the dairy industry in northern Europe, followed by re-emergence in the 21st century. Here, we sought to explain this re-emergence based on short and long read sequencing of historical (1953–1978; n=44) and contemporary (1997–2012; n=76) bovine GBS isolates. Our data show that a globally distributed bovine-associated lineage of GBS was commonly detected among historical isolates but never among contemporary isolates. By contrast, tetracycline resistance, which is present in all major GBS clones adapted to humans, was commonly and uniquely detected in contemporary bovine isolates. These observations provide evidence for strain replacement and suggest a human origin of newly emerged strains. Three novel GBS plasmids were identified, including two showing >98 % sequence similarity with plasmids from Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis , which co-exist with GBS in the human oropharynx. Our findings support introduction of GBS into the dairy population due to human-to-cattle jumps on multiple occasions and demonstrate that reverse zoonotic transmission can erase successes of animal disease control campaigns

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

BACKGROUND: Oxidative stress, resulting from the increased oxidative burden and decreased level of antioxidant proteins, plays a role in the pathophysiology of smoking-related pulmonary emphysema. Expression of several antioxidant proteins, such as heme oxygenase-1 (HO-1), glutathione peroxidase 2 (GPX2) and NAD(P)H:quinone oxidoreductase 1 (NQO1), results from an equilibrium created by positive or negative regulation by the transcription factors Nrf2, Keap1 and Bach1, respectively. However, whether the expression of these transcription factors is altered in emphysema and could account for decreased expression of antioxidant proteins is not known. A study was undertaken to investigate the expression and subcellular localisation of Nrf2, Keap1 and Bach1 as potential regulators of HO-1, GPX2 and NQO1 in alveolar macrophages, a key cell in oxidative stress, in lung surgical specimens from non-smokers without emphysema and smokers with and without emphysema. METHODS AND RESULTS: Western blot, immunohistochemical and laser scanning confocal analysis revealed that the Nrf2 protein level decreased significantly in whole lung tissue and alveolar macrophages (cytosol and nucleus) in patients with emphysema compared with those without emphysema. Conversely, Bach1 and Keap1 levels were increased in patients with emphysema. These modifications were associated with a parallel decrease in the expression of HO-1, GPX2 and NQO1 at the cellular level, which was inversely correlated with airway obstruction and distension indexes, and increased macrophage expression of the lipid peroxidation product 4-hydroxy-2-nonenal. Silencing RNA experiments in vitro in THP-1 cells were performed to confirm the cause-effect relation between the loss of Nrf2 and the decrease in HO-1, NQO1 and GPX2 expression. Nrf2/Keap1-Bach1 equilibrium was altered in alveolar macrophages in pulmonary emphysema, which points to a decreased stress response phenotype. CONCLUSIONS: This finding opens a new view of the pathophysiology of emphysema and could provide the basis for new therapeutic approaches based on preservation and/or restoration of such equilibrium