IL CARCINOMA DEL COLON-RETTO METASTATICO: ANALISI EPIDEMIOLOGICA E FARMACOECONOMICA ALLA LUCE DELLA LETTERATURA E DELLE DISPOSIZIONI AIFA SUI FARMACI SOTTOPOSTI A REGISTRO DI MONITORAGGIO

Negli ultimi anni i farmaci innovativi si sono affiancati ai chemioterapici classici andando a modificare in modo radicale non solo le terapie, ma anche la capacità delle stesse di ottenere un buon controllo della patologia a fronte di profili di tossicità prevedibili e gestibili, allungando in modo apprezzabile e migliorando la qualità della vita dei pazienti affetti dalla malattia oncologica. E proprio questi farmaci hanno rappresentato una novità non solo per quel che riguarda la clinica ma anche per la loro gestione e per gli innovativi strumenti di acquisizione, pagamento e rimborso introdotti dall’AIFA che hanno attribuito al Farmacista Ospedaliero nuove competenze e responsabilità di gestione. L’aspetto forse più importante e innovativo è che la continua evoluzione dello strumento gestionale dei farmaci oncologici innovativi voluto da AIFA, ha portato il Farmacista Ospedaliero a stretto contatto con i reparti per condividere le novità via via introdotte dall’Agenzia nel monitoraggio di nuovi farmaci e per gestire insieme ai Medici la prescrizione e l’erogazione delle terapie, avvicinandolo sempre di più alla figura del Farmacista di Dipartimento ampiamente testata e con risultati fortemente positivi nel mondo anglosassone in termini di appropriatezza nell’uso dei farmaci e di risparmio per il Servizio Pubblico, in un momento storico in cui la sostenibilità e l’uso efficace ed efficiente delle risorse disponibili è un fattore imprescindibile per continuare a garantire in futuro un Sistema universalistico e gratuito

Elastic properties of concrete at early age : monitoring of the e-modulus and the poisson's ratio with cyclic loadings and ultrasonic measurements

Knowledge of early age evolutions of the concrete properties is of a great interest for predictions of cracking risks. In this period, from the time of setting, disorders govern the future durability of concrete. Numerical computations coupled with Experimental investigations on samples are common strategies to predict the behaviour of structures. Heat release, strength evolutions, autogenous and thermal strains, time of setting, elastic and delayed deformations have to be taken into account. Among these properties, the Poisson's ratio is scarcely evaluated. Measurements are tricky even on hardened materials. At early age, accurate determinations are even more delicate. Some results can be found in the literature on early age evolutions of Young's modulus and Poisson's ratio either with static testing (e.g. [De Schutter & Taerwe, 1996], [Boulay et al., 2010]) or ultrasonic measurements ([Boumiz et al., 1996] for example). In this paper a comparison is achieved between these two techniques applied to an ordinary concrete (CEM I, w/c: 0.5). The comparison between static and dynamic Poisson's ratio show a linear relationship. Static and dynamic Young's modulus evolutions are also compared. Classically, on hardened concrete, it is reported that dynamic values are greater than static values. It is naturally confirmed here and it is observed that the Edyn/Estat ratio decreases during the hardening process of the material. This evolution is attributed to the water content linked to the hydration process

Monitoring of the creep and the relaxation behaviour of concrete since setting time, part 1: compression

This paper (part 1& 2) presents an experimental methodology using two different test rigs enabling a monitoring of the stiffness, the creep or the relaxation of a concrete sample since setting time. Tension and compressive tests realized on a revisited Temperature Stress Testing Machine TSTM [1] at ULB are presented in a second part while compressive tests, realized on another test rig called BTJASPE [2] designed at IFSTTAR, are presented in the first one. In each part, rheological models are used for the description of the experimental set of data. The purpose of this study is to investigate the question of the equivalence between the early age creep and relaxation behaviour of concrete in tension and in compression for a typical reference ordinary concrete in sealed conditions

Monitoring of the Creep and the Relaxation Behavior of Concrete Since Setting Time, Part 2: Tension

info:eu-repo/semantics/publishe

Monitoring of the creep and the relaxation behaviour of concrete since setting time, part 1 :compression

info:eu-repo/semantics/publishe

Elastic properties of concrete at early age: monitoring of the e-modulus and the poisson's ratio with cyclic loadings and ultrasonic measurements

Knowledge of early age evolutions of the concrete properties is of a great interest for predictions of cracking risks. In this period, from the time of setting, disorders govern the future durability of concrete. Numerical computations coupled with Experimental investigations on samples are common strategies to predict the behaviour of structures. Heat release, strength evolutions, autogenous and thermal strains, time of setting, elastic and delayed deformations have to be taken into account. Among these properties, the Poisson's ratio is scarcely evaluated. Measurements are tricky even on hardened materials. At early age, accurate determinations are even more delicate. Some results can be found in the literature on early age evolutions of Young's modulus and Poisson's ratio either with static testing (e.g. [De Schutter & Taerwe, 1996], [Boulay et al. 2010]) or ultrasonic measurements ([Boumiz et al. 1996] for example). In this paper a comparison is achieved between these two techniques applied to an ordinary concrete (CEM I, w/c: 0.5). The comparison between static and dynamic Poisson's ratio show a linear relationship. Static and dynamic Young's modulus evolutions are also compared. Classically, on hardened concrete, it is reported that dynamic values are greater than static values. It is naturally confirmed here and it is observed that the Edyn/Estat ratio decreases during the hardening process of the material. This evolution is attributed to the water content linked to the hydration process.info:eu-repo/semantics/publishe