1 research outputs found
Determinants of the Presence and Size of Intracranial Aneurysms in the General Population The Rotterdam Study
BACKGROUND AND PURPOSE: The prevalence of unruptured intracranial aneurysms (UIAs) in the adult population is β3%.
Rupture of an intracranial aneurysm can have devastating consequences, which emphasizes the importance of identification
of potentially modifiable determinants for the presence and size of UIAs. Our aim was to study the association of a broad
spectrum of potential determinants with the presence and size of UIAs in a general adult population.
METHODS: Between 2005 and 2015, 5841 participants from the population-based Rotterdam Study (mean age, 64.4
years, 45.0% male) underwent brain magnetic resonance imaging (1.5T). These scans were evaluated for the presence of
incidental UIAs. We determined number and volume of the UIAs. Using logistic and linear regression models, we assessed
the association of cardiovascular, lifestyle and emerging inflammatory and hormonal determinants with the presence and
volume of UIAs.
RESULTS: In 134 (2.3%) participants, β₯1 UIAs were detected (149 UIAs in total), with a median volume of 61.1 mm3
(interquartile range, 33.2β134.0). In multivariable models, female sex (odds ratio, 1.92 [95% CI, 1.33β2.84]), hypertension
(odds ratio, 1.73 [95% CI, 1.13β2.68]), and current smoking (odds ratio, 3.75 [95% CI, 2.27β6.33]) were associated with
the presence of UIAs. We found no association of alcohol use, physical activity, or diet quality with UIA presence. Finally, we
found white blood cell count to relate to larger aneurysm volume (difference in volume of 33.6 mm3 per 109/L increase in
white blood cell [95% CI, 3.92β63.5]).
CONCLUSIONS: In this population-based study, female sex, hypertension, and smoking, but no other lifestyle determinants, were
associated with the presence of UIAs. White blood cell count is associated with size of UIAs. Preventive strategies should
focus on treating hypertension and promoting cessation of smoking