2,537 research outputs found
Opportunity for All: How the American Public Benefits From Internet Access at U.S. Libraries
Examines the use of free computer and Internet access in public libraries, by income level, age, race/ethnicity, and online activity. Explores libraries' role as a community resource for social media, education, employment, e-government, and other areas
An overview of Viscosity Solutions of Path-Dependent PDEs
This paper provides an overview of the recently developed notion of viscosity
solutions of path-dependent partial di erential equations. We start by a quick
review of the Crandall- Ishii notion of viscosity solutions, so as to motivate
the relevance of our de nition in the path-dependent case. We focus on the
wellposedness theory of such equations. In partic- ular, we provide a simple
presentation of the current existence and uniqueness arguments in the
semilinear case. We also review the stability property of this notion of
solutions, in- cluding the adaptation of the Barles-Souganidis monotonic scheme
approximation method. Our results rely crucially on the theory of optimal
stopping under nonlinear expectation. In the dominated case, we provide a
self-contained presentation of all required results. The fully nonlinear case
is more involved and is addressed in [12]
Dynamical response of the "GGG" rotor to test the Equivalence Principle: theory, simulation and experiment. Part I: the normal modes
Recent theoretical work suggests that violation of the Equivalence Principle
might be revealed in a measurement of the fractional differential acceleration
between two test bodies -of different composition, falling in the
gravitational field of a source mass- if the measurement is made to the level
of or better. This being within the reach of ground based
experiments, gives them a new impetus. However, while slowly rotating torsion
balances in ground laboratories are close to reaching this level, only an
experiment performed in low orbit around the Earth is likely to provide a much
better accuracy.
We report on the progress made with the "Galileo Galilei on the Ground" (GGG)
experiment, which aims to compete with torsion balances using an instrument
design also capable of being converted into a much higher sensitivity space
test.
In the present and following paper (Part I and Part II), we demonstrate that
the dynamical response of the GGG differential accelerometer set into
supercritical rotation -in particular its normal modes (Part I) and rejection
of common mode effects (Part II)- can be predicted by means of a simple but
effective model that embodies all the relevant physics. Analytical solutions
are obtained under special limits, which provide the theoretical understanding.
A simulation environment is set up, obtaining quantitative agreement with the
available experimental data on the frequencies of the normal modes, and on the
whirling behavior. This is a needed and reliable tool for controlling and
separating perturbative effects from the expected signal, as well as for
planning the optimization of the apparatus.Comment: Accepted for publication by "Review of Scientific Instruments" on Jan
16, 2006. 16 2-column pages, 9 figure
On the Path Integral in Imaginary Lobachevsky Space
The path integral on the single-sheeted hyperboloid, i.e.\ in -dimensional
imaginary Lobachevsky space, is evaluated. A potential problem which we call
``Kepler-problem'', and the case of a constant magnetic field are also
discussed.Comment: 16 pages, LATEX, DESY 93-14
Dynamics of a lattice Universe
We find a solution to Einstein field equations for a regular toroidal lattice
of size L with equal masses M at the centre of each cell; this solution is
exact at order M/L. Such a solution is convenient to study the dynamics of an
assembly of galaxy-like objects. We find that the solution is expanding (or
contracting) in exactly the same way as the solution of a
Friedman-Lema\^itre-Robertson-Walker Universe with dust having the same average
density as our model. This points towards the absence of backreaction in a
Universe filled with an infinite number of objects, and this validates the
fluid approximation, as far as dynamics is concerned, and at the level of
approximation considered in this work.Comment: 14 pages. No figure. Accepted version for Classical and Quantum
Gravit
Expansion Dating: Calibrating Molecular Clocks in Marine Species from Expansions onto the Sunda Shelf Following the Last Glacial Maximum
The rate of change in DNA is an important parameter for understanding molecular evolution and hence for inferences drawn from studies of phylogeography and phylogenetics. Most rate calibrations for mitochondrial coding regions in marine species have been made from divergence dating for fossils and vicariant events older than 1-2 My and are typically 0.5-2% per lineage per million years. Recently, calibrations made with ancient DNA (aDNA) from younger dates have yielded faster rates, suggesting that estimates of the molecular rate of change depend on the time of calibration, decaying from the instantaneous mutation rate to the phylogenetic substitution rate. aDNA methods for recent calibrations are not available for most marine taxa so instead we use radiometric dates for sea-level rise onto the Sunda Shelf following the Last Glacial Maximum (starting similar to 18,000 years ago), which led to massive population expansions for marine species. Instead of divergence dating, we use a two-epoch coalescent model of logistic population growth preceded by a constant population size to infer a time in mutational units for the beginning of these expansion events. This model compares favorably to simpler coalescent models of constant population size, and exponential or logistic growth, and is far more precise than estimates from the mismatch distribution. Mean rates estimated with this method for mitochondrial coding genes in three invertebrate species are elevated in comparison to older calibration points (2.3-6.6% per lineage per million years), lending additional support to the hypothesis of calibration time dependency for molecular rates
Inhibition of Nitric Oxide Inhibition of Nitric Oxide Synthase Does Not Alter Dynamic Cerebral Autoregulation in Humans
The aim of this study was to determine whether inhibition of nitric oxide synthase (NOS) alters dynamic cerebral autoregulation in humans. Beat-to-beat blood pressure (BP) and cerebral blood flow (CBF) velocity (transcranial Doppler) were measured in eight healthy subjects in the supine position and during 60° head-up tilt (HUT). NOS was inhibited by intravenous N G-monomethyl-L-arginine (L-NMMA) infusion. Dynamic cerebral autoregulation was quantified by transfer function analysis of beat-to-beat changes in BP and CBF velocity. Pressor effects of L-NMMA on cerebral hemodynamics were compared with those of phenylephrine infusion. In the supine position, L-NMMA increased mean BP from 83 ± 3 to 94 ± 3 mmHg (P \u3c 0.01). However, CBF velocity remained unchanged. Consequently, cerebrovascular resistance index (CVRI) increased by 15% (P \u3c 0.05). BP and CBF velocity variability and transfer function gain at the low frequencies of 0.07-0.20 Hz did not change with L-NMMA infusion. Similar changes in mean BP, CBF velocity, and CVRI were observed after phenylephrine infusion, suggesting that increase in CVRI after L-NMMA was mediated myogenically by increase in arterial pressure rather than a direct effect of cerebrovascular NOS inhibition. During baseline tilt without L-NMMA, steady-state BP increased and CBF velocity decreased. BP and CBF velocity variability at low frequencies increased in parallel by 277% and 217%, respectively (P \u3c 0.05). However, transfer function gain remained unchanged. During tilt with L-NMMA, changes in steady-state hemodynamics and BP and CBF velocity variability as well as transfer gain and phase were similar to those without L-NMMA. These data suggest that inhibition of tonic production of NO does not appear to alter dynamic cerebral autoregulation in humans
Nitric Oxide Synthase Inhibition Does Not Affect Regulation of Muscle Sympathetic Nerve Activity During Head-Up Tilt
To test the hypothesis that systemic inhibition of nitric oxide (NO) synthase does not alter the regulation of sympathetic outflow during head-up tilt in humans, in eight healthy subjects NO synthase was blocked by intravenous infusion of NG-monomethyl-L-arginine (L-NMMA). Blood pressure, heart rate, cardiac output, total peripheral resistance (TPR), and muscle sympathetic nerve activity (MSNA) were recorded in the supine position and during 60° head-up tilt. In the supine position, infusion of L-NMMA increased blood pressure, via increased TPR, and inhibited MSNA. However, the increase in MSNA evoked by head-up tilt during L-NMMA infusion (change in burst rate: 24 ± 4 bursts/min; change in total activity: 209 ± 36 U/min) was similar to that during head-up tilt without L-NMMA (change in burst rate: 23 ± 4 bursts/min; change in total activity: 251 ± 52 U/min, n = 6, all P \u3e 0.05). Moreover, changes in TPR and heart rate during head-up tilt were virtually identical between the two conditions. These results suggest that systemic inhibition of NO synthase with L-NMMA does not affect the regulation of sympathetic outflow and vascular resistance during head-up tilt in humans
Expansion Dating: Calibrating Molecular Clocks in Marine Species from Expansions onto the Sunda Shelf following the Last Glacial Maximum
The rate of change in DNA is an important parameter for understanding molecular evolution, and hence for inferences drawn from studies of phylogeography and phylogenetics. Most rate calibrations for mitochondrial coding regions in marine species have been made from divergence dating for fossils and vicariant events older than 1-2 million years, and are typically 0.5% - 2% per lineage per million years. Recently, calibrations made with ancient DNA from younger dates have yielded faster rates, suggesting that estimates of the molecular rate of change depend on the time of calibration, decaying from the instantaneous mutation rate to the phylogenetic substitution rate. Ancient DNA methods for recent calibrations are not available for most marine taxa so instead we use radiometric dates for sea-level rise onto the Sunda Shelf following the Last Glacial Maximum (starting ~18,000 years ago), which led to massive population expansions for marine species. Instead of divergence dating, we use a two epoch coalescent model of logistic population growth preceded by a constant population size to infer a time in mutational units for the beginning of these expansion events. This model compares favorably to simpler coalescent models of constant population size, and exponential or logistic growth, and is far more precise than estimates from the mismatch distribution. Mean rates estimated with this method for mitochondrial coding genes in three invertebrate species are elevated in comparison to older calibration points (2.3% - 6.6% per lineage per million years), lending additional support to the hypothesis of calibration time-dependency for molecular rates
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