Donald M. Crader to Dr. Silver, 12 July 1963

Professional correspondenc

The relationship of the pastors\u27 sermon preparation methods to average worship attendance in the churches of the Missouri East Conference of the United Methodist Church

https://place.asburyseminary.edu/ecommonsatsdissertations/1107/thumbnail.jp

Increased GABAA Receptor ε-Subunit Expression on Ventral Respiratory Column Neurons Protects Breathing during Pregnancy

GABAergic signaling is essential for proper respiratory function. Potentiation of this signaling with allosteric modulators such as anesthetics, barbiturates, and neurosteroids can lead to respiratory arrest. Paradoxically, pregnant animals continue to breathe normally despite nearly 100-fold increases in circulating neurosteroids. ε subunit-containing GABAARs are insensitive to positive allosteric modulation, thus we hypothesized that pregnant rats increase ε subunit-containing GABAAR expression on brainstem neurons of the ventral respiratory column (VRC). In vivo, pregnancy rendered respiratory motor output insensitive to otherwise lethal doses of pentobarbital, a barbiturate previously used to categorize the ε subunit. Using electrode array recordings in vitro, we demonstrated that putative respiratory neurons of the preBötzinger Complex (preBötC) were also rendered insensitive to the effects of pentobarbital during pregnancy, but unit activity in the VRC was rapidly inhibited by the GABAAR agonist, muscimol. VRC unit activity from virgin and post-partum females was potently inhibited by both pentobarbital and muscimol. Brainstem ε subunit mRNA and protein levels were increased in pregnant rats, and GABAAR ε subunit expression co-localized with a marker of rhythm generating neurons (neurokinin 1 receptors) in the preBötC. These data support the hypothesis that pregnancy renders respiratory motor output and respiratory neuron activity insensitive to barbiturates, most likely via increased ε subunit-containing GABAAR expression on respiratory rhythm-generating neurons. Increased ε subunit expression may be critical to preserve respiratory function (and life) despite increased neurosteroid levels during pregnancy

Utilisation préhistorique du castor sur la côte du Maine (Etats-Unis)

En s\u27appuyant sur les données fauniques et archéologiques, cet article éxamine l\u27utilisation préhistorique du castor par les indigènes de la côte du Maine. Il est centré sur la faune de Richards, un site de la période céramique d\u27avanl le contact avec les Européens, situé au centre de la côte du Maine. L\u27assemblage faunique est dominé par le castor et représente le plus important échantillon d\u27os de castor préhistoriques non calcinés jamais rassemblé et analysé. Cette collection nous fournit des indications directes sur l\u27utilisation que les indigènes faisaient du castor dans la période antérieure au contact avec les Européens. Les données sur la représentation des différentes parties du corps, le nombre minimum d\u27animaux et les traces de découpe révèlent que des carcasses entières étaient traitées sur le site, et que les animaux adultes ou les animaux de grande taille n\u27ayant pas atteint l\u27âge adulte étaient sélectionnés. Une comparaison de l\u27étude des données sur les castors du site de Richards avec d\u27autres sites préhistoriques de la région montre un accroissement de l\u27utilisation du castor dès avant la demande de fourrures des Européens.ln this paper the prehistoric use of beaver by native peoples along the coast of Maine is examined using archaeological faunal evidence. The focus of the puper is the fauna from the Richards site, a pre-contact Ceramic Period site located on the central coast of Maine, The faunal assemblage is dominated by heaver and is the largest, non-calcined sample of prehistoric beaver bone in the region ever to be recovered and analyzed, providing direct evidence for how beavers were used by native peoples before European contact. Data on body part representation, minimum number of individuals and butchery marks reveal that whole carcasses were being processed at the site and that adults or large subadults were preferred. A comparison of the Richards beaver data with other prehistoric sites in the region shows that, through time, a shift toward increased utilization of beaver occurred prior to the European demand for pelts.</p

Faculty Recitals

Faculty Recital performance at UNT's College of Music Concert Hal

Microcontroller Educational Device (MED)

Deathstar Engineering took on the task of creating a microcontroller kit in the form of a portable demonstration. In the project proposal, the main objective was to teach microcontroller programming to users. The original sponsors of the project were interested in learning to program a variety of outputs for three controllers in particular: Arduino, Beaglebone, and Raspberry Pi. It was also intended that the product would need to be interactive and easy to use for beginners. The product, designed by Deathstar Engineering, differentiates itself from the currently available choices by combining all of the different hardware programming interfaces into a single, easy to use system that will allow the user to experiment with several units, thus increasing the learning potential and value of the product. The product also mainly targets K-12 schools while keeping the design open and flexible to allow anyone who has an interest in programming microcontrollers to use the product. By creating the product in this way, it will fill a niche in the market that does not exist at this time. Fig. 1 shows the completed product, the Microcontroller Educational Device (MED)