The state of gender diversity in medical physics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154924/1/mp14035.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154924/2/mp14035_am.pd

Exact microscopic analysis of a thermal Brownian motor

We study a genuine Brownian motor by hard disk molecular dynamics and calculate analytically its properties, including its drift speed and thermal conductivity, from microscopic theory.Comment: 4 pages, 5 figure

Low-energy quasiparticle states near extended scatterers in d-wave superconductors and their connection with SUSY quantum mechanics

Low-energy quasiparticle states, arising from scattering by single-particle potentials in d-wave superconductors, are addressed. Via a natural extension of the Andreev approximation, the idea that sign-variations in the superconducting pair-potential lead to such states is extended beyond its original setting of boundary scattering to the broader context of scattering by general single-particle potentials, such as those due to impurities. The index-theoretic origin of these states is exhibited via a simple connection with Witten's supersymmetric quantum-mechanical model.Comment: 5 page

Zero-energy Andreev surface bound states in the lattice model

The conditions for zero-energy Andreev surface bound states to exist are found for the lattice model of d-wave superconductor with arbitrary surface orientation. Both nearest neighbors and next nearest neighbors models are considered. It is shown that the results are very sensitive to the surface orientation. In particular, for half-filled $(hl0)$-surface zero-energy Andreev surface states only appear under the condition that $h$ and $l$ are odd simultaneouslyComment: 9 pages, 1 figur

Spontaneous flux in a d-wave superconductor with time-reversal-symmetry-broken pairing state at {110} boundaries

The induction of an s-wave component in a d-wave superconductor is considered. Near the {110}-oriented edges of such a sample, the induced s-wave order parameter together with d-wave component forms a complex combination d+e^{i\phi} s, which breaks the time reversal symmetry (BTRS) of the pairing state. As a result, the spontaneous current is created. We numerically study the current distribution and the formation of the spontaneous flux induced by the current. We show that the spontaneous flux formed from a number of defect lines with {110} orientation has a measurable strength. This result may provide a unambiguous way to check the existence of BTRS pairing state at {110}-oriented boundaries.Comment: 4 pages, 2 ps-figures, content changed, references adde

Discrete-Lattice Model for Surface Bound States and Tunneling in d-Wave Superconductors

Surface bound states in a discrete-lattice model of a $d_{x^2 - y^2}$ cuprate superconductor are shown to be, in general, coherent superpositions of an incoming excitation and more than one outgoing excitation, and a simple graphical construction based on a surface Brillouin zone is developed to describe their nature. In addition, a momentum-dependent lifetime contribution to the width of these bound states as observed in tunneling experiments is derived and elucidated in physical terms.Comment: 4 pages, 1 figure, revte

The effect of galaxy mass ratio on merger--driven starbursts

We employ numerical simulations of galaxy mergers to explore the effect of galaxy mass ratio on merger--driven starbursts. Our numerical simulations include radiative cooling of gas, star formation, and stellar feedback to follow the interaction and merger of four disk galaxies. The galaxy models span a factor of 23 in total mass and are designed to be representative of typical galaxies in the local Universe. We find that the merger--driven star formation is a strong function of merger mass ratio, with very little, if any, induced star formation for large mass ratio mergers. We define a burst efficiency that is useful to characterize the merger--driven star formation and test that it is insensitive to uncertainties in the feedback parameterization. In accord with previous work we find that the burst efficiency depends on the structure of the primary galaxy. In particular, the presence of a massive stellar bulge stabilizes the disk and suppresses merger--driven star formation for large mass ratio mergers. Direct, co--planar merging orbits produce the largest tidal disturbance and yield that most intense burst of star formation. Contrary to naive expectations, a more compact distribution of gas or an increased gas fraction both decrease the burst efficiency. Owing to the efficient feedback model and the newer version of SPH employed here, the burst efficiencies of the mergers presented here are smaller than in previous studies.Comment: 26 pages, 21 figures, submitted to MNRA

Radar plots: A novel modality for displaying disparate data on the efficacy of eluxadoline for the treatment of irritable bowel syndrome with diarrhea

BackgroundPatients with irritable bowel syndrome with diarrhea (IBS‐D) experience a range of abdominal and bowel symptoms; successful management requires alleviation of this constellation of symptoms. Eluxadoline, a locally active mixed μ‐ and κ‐opioid receptor agonist and δ‐opioid receptor antagonist, is approved for the treatment of IBS‐D in adults based on the results of 2 Phase 3 studies. Radar plots can facilitate comprehensive, visual evaluation of diverse but interrelated efficacy endpoints.MethodsTwo double‐blind, placebo‐controlled, Phase 3 trials (IBS‐3001 and IBS‐3002) randomized patients meeting Rome III criteria for IBS‐D to twice‐daily eluxadoline 75 or 100 mg or placebo. Radar plots were prepared showing pooled Weeks 1‐26 response rates for the primary efficacy composite endpoint (simultaneous improvement in abdominal pain and stool consistency), stool consistency, abdominal pain, urgency‐free days, and adequate relief, and change from baseline to Week 26 in IBS‐D global symptom score, abdominal discomfort, abdominal pain, abdominal bloating, and daily number of bowel movements.Key ResultsThe studies enrolled 2428 patients. Eluxadoline increased Weeks 1‐26 responder proportions vs placebo for the composite endpoint, stool consistency, abdominal pain, urgency‐free days, and adequate relief. Changes from baseline to Week 26 in IBS‐D global symptom score, abdominal discomfort, abdominal pain, abdominal bloating, and number of bowel movements were greater with eluxadoline vs placebo.Conclusions and InferencesData presentation in radar plot format facilitates interpretation across multiple domains, demonstrating that eluxadoline treatment led to improvements vs placebo across 13 endpoints representing the range of symptoms experienced by patients with IBS‐D.Data presentation in radar plot format can facilitate evaluation of the diverse array of symptoms and outcomes that are relevant to a symptom‐based condition like irritable bowel syndrome with diarrhea (IBS‐D). In 2 Phase 3 trials, eluxadoline treatment improved stool consistency and frequency, abdominal pain, bloating and discomfort, feelings of urgency, global symptom score, and adequate relief. Radar plots provide a visual demonstration of improvements with eluxadoline across 13 endpoints encompassing the diverse constellation of symptoms experienced by patients with IBS‐D.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145265/1/nmo13331_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145265/2/nmo13331.pd

Realistic Surface Scattering and Surface Bound State Formation in the High T_c Superconductor YBa_2Cu_3O_{6+x}

Surface Umklapp scattering of quasiparticles, and surface roughness are shown to play essential roles in the formation of the surface bound states in realistic models for YBa_2Cu_3O_{6+x}. The results account for the shape, the impurity dependence of the height, and for a proposed universal width of the zero bias conductance peak.Comment: 4 pages, 1 figur