Quelques Desmidiées (Algae, Zygophyceae) de Guyane française étudiées au M.E.B.

Les auteurs étudient à l'aide du M.E.B. vingt taxons appartenant à la famille des Desmidiacées et aux genres #Actinotaenium, #Cosmarium, #Desmidium, #Euastrum, #Micrasterias, #Phymatodocis, #Staurastrum, #Streptonema et #Xanthidium. Quarante documents photographiques, réunis en cinq planches, présentent des vues originales d'ensemble et de détails, en particulier de cinq espèces ou variétés récemment décrites. Trois nouvelles variétés sont proposées pour les genres #Euastrum et #Micrasterias$. (Résumé d'auteur

Argonaute Autoantibodies as Biomarkers in Autoimmune Neurologic Diseases

OBJECTIVE: To identify and characterize autoantibodies (Abs) as novel biomarkers for an autoimmune context in patients with central and peripheral neurologic diseases. METHODS: Two distinct approaches (immunoprecipitation/mass spectrometry-based proteomics and protein microarrays) and patients' sera and CSF were used. The specificity of the identified target was confirmed by cell-based assay (CBA) in 856 control samples. RESULTS: Using the 2 methods as well as sera and CSF of patients with central and peripheral neurologic involvement, we identified Abs against the family of Argonaute proteins (mainly AGO1 and AGO2), which were already reported in systemic autoimmunity. AGO-Abs were mostly of immunoglobulin G 1 subclass and conformation dependent. Using CBA, AGO-Abs were detected in 21 patients with a high suspicion of autoimmune neurologic diseases (71.4% were women; median age 57 years) and only in 4/856 (0.5%) controls analyzed by CBA (1 diagnosed with small-cell lung cancer and the other 3 with Sjögren syndrome). Among the 21 neurologic patients identified, the main clinical presentations were sensory neuronopathy (8/21, 38.1%) and limbic encephalitis (6/21, 28.6%). Fourteen patients (66.7%) had autoimmune comorbidities and/or co-occurring Abs, whereas AGO-Abs were the only autoimmune biomarker for the remaining 7/21 (33.3%). Thirteen (61.9%) patients were treated with immunotherapy; 8/13 (61.5%) improved, and 3/13 (23.1%) remained stable, suggesting an efficacy of these treatments. CONCLUSIONS: AGO-Abs might be potential biomarkers of autoimmunity in patients with central and peripheral nonparaneoplastic neurologic diseases. In 7 patients, AGO-Abs were the only biomarkers; thus, their identification may be useful to suspect the autoimmune character of the neurologic disorder. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that AGO-Abs are more frequent in patients with autoimmune neurologic diseases than controls

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells

Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process. Ribosome biogenesis is a very complex process involving transcriptional a

A Protein Inventory of Human Ribosome Biogenesis Reveals an Essential Function of Exportin 5 in 60S Subunit Export

A systematic search for human ribosome biogenesis factors shows conservation of many aspects of eukaryotic ribosome synthesis with the well-studied process in yeast and identifies an export route of 60S subunits that is specific for higher eukaryotes

Quelques Desmidiées (Algae, Zygophyceae) de Guyane française étudiées au M.E.B.

Les auteurs étudient à l'aide du M.E.B. vingt taxons appartenant à la famille des Desmidiacées et aux genres #Actinotaenium, #Cosmarium, #Desmidium, #Euastrum, #Micrasterias, #Phymatodocis, #Staurastrum, #Streptonema et #Xanthidium. Quarante documents photographiques, réunis en cinq planches, présentent des vues originales d'ensemble et de détails, en particulier de cinq espèces ou variétés récemment décrites. Trois nouvelles variétés sont proposées pour les genres #Euastrum et #Micrasterias$. (Résumé d'auteur

Algues d'eau douce des iles Kerguelen et Crozet (a l'exclusion des diatomees). II. Examen des recoltes effectuees en 1973 et 1974

National audienc

Chlamydomonas reinhardtii Chloroplasts Contain a Homodimeric Pyruvate:Ferredoxin Oxidoreductase That Functions with FDX1

Chlamydomonas reinhardtii Chloroplasts Contain a Homodimeric Pyruvate:Ferredoxin Oxidoreductase That Functions with FDX

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction

International audienc