Culture des jardins maraîchers du Midi de la France / par M. Maffre,...

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Additional file 3: Figure S3. of The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles

Phylogenetic analysis of TOMM D proteins. A maximum likelihood tree was constructed using the D protein sequence from all TOMM producers. The class of characterized TOMM was then mapped on with colored circles as represented in the legend. Similar TOMM clusters seen in the sequence similarity network (Fig. 2) are seen grouping here. (TIFF 1844 kb

Additional file 5: Figure S5. of The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles

The prevalence and phylogenetic distribution of enzymes involved in TOMM biosynthesis. A sequence similarity network with all proteins in the TOMM biosynthetic gene clusters visualized at a BLAST expectation value of 10−30. All proteins with 100 % identity were removed and are represented as larger nodes on the network (size is dependent on the number of removed proteins). (TIFF 9992 kb

Rux largely restores lungs in Iraq PM-exposed mice, Up-regulating regulatory T-cells (Tregs)

<p><b>Background</b> Military personnel post-deployment to Iraq and Afghanistan have noted new-onset respiratory illness. This study's primary objective was to further develop an animal model of Iraq Afghanistan War Lung Injury (IAW-LI) and to test a novel class of anti-injury drug called RuX. <b>Methods</b> Particulate Matter (PM) samples were obtained in Iraq then characterized by spectromicroscopy. C57BL/6 mice underwent orotracheal instillation with PM, followed by drinkable treatment with RuX. Lung histology, inspiratory capacity (FlexiVent), thymic/splenic regulatory T cell (Treg) number, and whole-lung genomics were analyzed. <b>Results</b> Tracheal instillation of Iraq PM led to lung septate thickening and lymphocytic inflammation. PM-exposed mice had suppression of thymic/splenic regulatory T-cells (Tregs). Drinking RuX after PM exposure attenuated the histologic lung injury response, improved lung inspiratory capacity, and increased Tregs. Pooled whole lung genomics suggest differences among gene expression of IL-15 among control, PM, and PM + RuX groups. <b>Conclusions</b> RuX, a ruthenium and alpha-lipoic acid complex, attenuates lung injury by improving histology and inspiratory capacity via upregulation of Tregs in Iraq PM-exposed C57BL/6. Plausible genomic effects may involve IL-15 whole lung gene expression.</p