Metabolism, excretion, and tissue distribution of [¹⁴C]photodieldrin in nonhuman primates following oral administration and intravenous injection.

Metabolism, excretion, and body distribution of [14C]photodieldrin were studied in the rhesus monkey (Macaca mulatta) after single intravenous and repeated oral administration. After iv administration about 45 and 34% of the dose were excreted by the male and the female, respectively, during 21 days following dosing. Approximately two-thirds of the excreted radioactivity was detected in the urine. The body distribution showed high concentrations of photodieldrin and/or metabolites in adipose tissue, liver, bile, bone marrow, mesenteric lymph nodes, and adrenal cortex. Analysis of feces and urine showed the presence of several metabolites. The major metabolite was identified by mass spectrometry, infrared spectrometry, and gas chromatographical comparison as trans-photoaldrindiol which appears in the urine as glucuronic acid conjugate and as free metabolite. A second metabolite, occurring in feces and urine, appears to be a monohydroxy substituted derivative of photodieldrin

Absorption, transport and organotropism of dichlorobiphenyl (DCB), Dieldrin, and hexachlorobenzene (HCB) in rats.

Sprague-Dawley rats were given a single dose of 150 μg of 14C-labeled DCB, Dieldrin, or HCB by stomach tube. At 1, 3, 5, 12, and 48 hour following dosing, one male and one female were killed. Samples of each organ or tissue were combusted and the 14CO2 content determined and the results averaged and recorded. DCB was rapidly absorbed from the gastrointestinal tract and transported to the liver mainly via the portal venous system, metabolized rapidly by the liver and excreted without significant storage. Dieldrin was similarly absorbed and transported to the liver; however, only a portion was metabolized and excreted, with redistribution and subsequent storage of most Dieldrin in the adipose tissue. HCB was more slowly absorbed with minor involvement of the portal venous system, and major absorption by the lymphatic system with subsequent deposition in the fat