Feasibility study of a hand guided robotic drill for cochleostomy

The concept of a hand guided robotic drill has been inspired by an automated, arm supported robotic drill recently applied in clinical practice to produce cochleostomies without penetrating the endosteum ready for inserting cochlear electrodes. The smart tactile sensing scheme within the drill enables precise control of the state of interaction between tissues and tools in real-time. This paper reports development studies of the hand guided robotic drill where the same consistent outcomes, augmentation of surgeon control and skill, and similar reduction of induced disturbances on the hearing organ are achieved. The device operates with differing presentation of tissues resulting from variation in anatomy and demonstrates the ability to control or avoid penetration of tissue layers as required and to respond to intended rather than involuntary motion of the surgeon operator. The advantage of hand guided over an arm supported system is that it offers flexibility in adjusting the drilling trajectory. This can be important to initiate cutting on a hard convex tissue surface without slipping and then to proceed on the desired trajectory after cutting has commenced. The results for trials on phantoms show that drill unit compliance is an important factor in the design

Using a Grid-Enabled Wireless Sensor Network for Flood Management

Flooding is becoming an increasing problem. As a result there is a need to deploy more sophisticated sensor networks to detect and react to flooding. This paper outlines a demonstration that illustrates our proposed solution to this problem involving embedded wireless hardware, component based middleware and overlay networks

Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing.

Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear. However, inaccessibility of inner ear tissue in humans severely restricts possibilities for experimental manipulation to develop therapies to ameliorate this loss. We provide a structural and functional analysis of human vestibular sensory epithelia harvested at trans-labyrinthine surgery. We demonstrate the viability of the tissue and labeling with specific markers of hair cell function and of ion homeostasis in the epithelium. Samples obtained from the oldest patients revealed a significant loss of hair cells across the tissue surface, but we found immature hair bundles present in epithelia harvested from patients >60 years of age. These results suggest that the environment of the human vestibular sensory epithelium could be responsive to stimulation of developmental pathways to enhance hair cell regeneration, as has been demonstrated successfully in the vestibular organs of adult mice

Cosmic Strings in an Open Universe with Baryonic and Non-Baryonic Dark Matter

We study the effects of cosmic strings on structure formation in open universes. We calculate the power spectrum of density perturbations for two class of models: one in which all the dark matter is non baryonic (CDM) and one in which it is all baryonic (BDM). Our results are compared to the 1 in 6 IRAS QDOT power spectrum. The best candidates are then used to estimate $\mu$, the energy per unit length of the string network. Some comments are made on mechanisms by which structures are formed in the two theories.Comment: uu-encoded compressed tar of postscript files, Imperial/TP/94-95/0

p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells

Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we show, using flow cytometry, that a small population of cells (0.3%) within the stem cell niche of the rat subventricular zone (SVZ) expresses the p75 neurotrophin receptor (p75(NTR)) and that these cells are responsible for neuron production in both newborn and adult animals. In the adult, the p75(NTR)-positive population contains all of the neurosphere-producing precursor cells, whereas in the newborn many of the precursor cells are p75(NTR) negative. However, at both ages, only the neurospheres derived from p75(NTR)-positive cells are neurogenic. We also show that neuron production from p75(NTR)-positive but not p75(NTR)-negative precursors is greatly enhanced after treatment with brain-derived neurotrophic factor (BDNF) or nerve growth factor. This effect appears to be mediated specifically by p75(NTR), because precursor cells from p75(NTR)-deficient mice show a 70% reduction in their neurogenic potential in vitro and fail to respond to BDNF treatment. Furthermore, adult p75(NTR)-deficient mice have significantly reduced numbers of PSA-NCAM ( polysialylated neural cell adhesion molecule)-positive SVZ neuroblasts in vivo and a lower olfactory bulb weight. Thus, p75(NTR) defines a discrete population of highly proliferative SVZ precursor cells that are able to respond to neurotrophin activation by increasing neuroblast generation, making this pathway the most likely mechanism for the increased neurogenesis that accompanies raised BDNF levels in a variety of disease and behavioral situations

Cepheid Period-Radius and Period-Luminosity Relations and the Distance to the LMC

We have used the infrared Barnes-Evans surface brightness technique to derive the radii and distances of 34 Galactic Cepheid variables. Radius and distance results obtained from both versions of the technique are in excellent agreement. The radii of 28 variables are used to determine the period-radius relation. This relation is found to have a smaller dispersion than in previous studies, and is identical to the period-radius relation found by Laney & Stobie from a completely independent method, a fact which provides persuasive evidence that the Cepheid period-radius relation is now determined at a very high confidence level. We use the accurate infrared distances to determine period-luminosity relations in the V, I, J, H and K passbands from the Galactic sample of Cepheids. We derive improved slopes of these relations from updated LMC Cepheid samples and adopt these slopes to obtain accurate absolute calibrations of the PL relation. By comparing these relations to the ones defined by the LMC Cepheids, we derive strikingly consistent and precise values for the LMC distance modulus in each of the passbands which yield a mean value of DM (LMC) = 18.46 +- 0.02. Our results show that the infrared Barnes-Evans technique is very insensitive to both Cepheid metallicity and adopted reddening, and therefore a very powerful tool to derive accurate distances to nearby galaxies by a direct application of the technique to their Cepheid variables, rather than by comparing PL relations of different galaxies, which introduces much more sensitivity to metallicity and absorption corrections which are usually difficult to determine.Comment: LaTeX, AASTeX style, 9 Figures, 10 Tables, The Astrophysical Journal in press (accepted Oct. 14, 1997). Fig. 3 replace

The Doppler Peaks from Cosmic Texture

We compute the angular power spectrum of temperature anisotropies on the microwave sky in the cosmic texture theory, with standard recombination assumed. The spectrum shows `Doppler' peaks analogous to those in scenarios based on primordial adiabatic fluctuations such as `standard CDM', but at quite different angular scales. There appear to be excellent prospects for using this as a discriminant between inflationary and cosmic defect theories.Comment: 14 pages, latex, 3 figures, compressed and uuencoded, replaced version has minor typographical correction

Global Defects in Field Theory with Applications to Condensed Matter

We review investigations on defects in systems described by real scalar fields in (D,1) space-time dimensions. We first work in one spatial dimension, with models described by one and two real scalar fields, and in higher dimensions. We show that when the potential assumes specific form, there are models which support stable global defects for D arbitrary. We also show how to find first-order differential equations that solve the equations of motion, and how to solve models in D dimensions via soluble problems in D=1. We illustrate the procedure examining specific models and showing how they may be used in applications in different contexts in condensed matter physics, and in other areas.Comment: 15 pages, 9 figure

Non-Gaussian CMBR angular power spectra

In this paper we show how the prediction of CMBR angular power spectra $C_l$ in non-Gaussian theories is affected by a cosmic covariance problem, that is $(C_l,C_{l'})$ correlations impart features on any observed $C_l$ spectrum which are absent from the average $C^l$ spectrum. Therefore the average spectrum is rendered a bad observational prediction, and two new prediction strategies, better adjusted to these theories, are proposed. In one we search for hidden random indices conditional to which the theory is released from the correlations. Contact with experiment can then be made in the form of the conditional power spectra plus the random index distribution. In another approach we apply to the problem a principal component analysis. We discuss the effect of correlations on the predictivity of non-Gaussian theories. We finish by showing how correlations may be crucial in delineating the borderline between predictions made by non-Gaussian and Gaussian theories. In fact, in some particular theories, correlations may act as powerful non-Gaussianity indicators