Second-line treatment in advanced gastric cancer : Data from the Spanish AGAMENON registry

Second-line treatments boost overall survival in advanced gastric cancer (AGC). However, there is a paucity of information as to patterns of use and the results achieved in actual clinical practice. The study population comprised patients with AGC in the AGAMENON registry who had received second-line. The objective was to describe the pattern of second-line therapies administered, progression-free survival following second-line (PFS-2), and post-progression survival since first-line (PPS). 2311 cases with 2066 progression events since first-line (89.3%) were recorded; 245 (10.6%) patients died during first-line treatment and 1326/2066 (64.1%) received a second-line. Median PFS-2 and PPS were 3.1 (95% CI, 2.9-3.3) and 5.8 months (5.5-6.3), respectively. The most widely used strategies were monoCT (56.9%), polyCT (15.0%), ramucirumab+CT (12.6%), platinum-reintroduction (8.3%), trastuzumab+CT (6.1%), and ramucirumab (1.1%). PFS-2/PPS medians gradually increased in monoCT, 2.6/5.1 months; polyCT 3.4/6.3 months; ramucirumab+CT, 4.1/6.5 months; platinum-reintroduction, 4.2/6.7 months, and for the HER2+ subgroup in particular, trastuzumab+CT, 5.2/11.7 months. Correlation between PFS since first-line and OS was moderate in the series as a whole (Kendall's τ = 0.613), lower in those subjects who received second-line (Kendall's τ = 0.539), especially with ramucirumab+CT (Kendall's τ = 0.413). This analysis reveals the diversity in second-line treatment for AGC, highlighting the effectiveness of paclitaxel-ramucirumab and, for a selected subgroup of patients, platinum reintroduction; both strategies endorsed by recent clinical guidelines

Plant Hosts of Botrytis spp.

A list of known plant species that serve as hosts of Botrytis spp. is presented. Botrytis species are reported to attack a total of 596 genera of vascular plants (tracheophytes), representing over 1400 plant species, although the host range is most probably much wider since there are limited reports of diseases on wild plants. B. cinerea was found on 586 genera, while the other species have narrower host ranges. Of the 596 genera, the majority (580) belongs to the Spermatophyta, 15 to the Pteridophyta and only 1 to the Lycopodiophyta. In the Spermatophyta, one genus belongs to Cycadophyta (cycads), 18 genera to the Pinophyta (conifers), one genus to the Ginkgophyta (ginkgo), and 562 genera to the Magnoliophyta (also known as fl owering plants or Angiospermae). Geographically, Botrytis spp. occur wherever their host plants are grown, ranging from tropical and subtropical areas to cold temperate zones of Northern and Southern globe regions including regions where plants are grown in extreme cold weather or where agriculture is practiced in the desert