Crustal architecture and geodynamics of North Queensland, Australia: insights from deep seismic reflection profiling

A deep crustal seismic reflection and magnetotelluric survey, conducted in 2007, established the architecture and geodynamic framework of north Queensland, Australia. Results based on the interpretation of the deep seismic data include the discovery of a major, west-dipping, Paleoproterozoic (or older) crustal boundary, considered to be an ancient suture zone, separating relatively nonreflective, thick crust of the Mount Isa Province from thinner, two layered crust to the east. Farther to the east, a second major crustal boundary also dips west or southwest, offsetting the Moho and extending below it, and is interpreted as a fossil subduction zone. Across the region, the lower crust is mostly highly reflective and is subdivided into three mappable seismic provinces, but they have not been tracked to the surface. In the east, the Greenvale and Charters Towers Provinces, part of the Thomson Orogen, have been mapped on the surface as two discrete provinces, but the seismic interpretation raises the possibility that these two provinces are continuous in the subsurface, and also extend northwards to beneath the Hodgkinson Province, originally forming part of an extensive Neoproterozoic– Cambrian passive margin. Continuation of the Thomson Orogen at depth beneath the Hodgkinson and Broken River Provinces suggests that these provinces (which formed in an oceanic environment, possibly as an accretionary wedge at a convergent margin) have been thrust westwards onto the older continental passive margin. The Tasman Line, originally defined to represent the eastern limit of Precambrian rocks in Australia, has a complicated geometry in three dimensions, which is related to regional deformational events during the Paleozoic. Overall, the seismic data show evidence for a continental margin with a long history (Paleoproterozoic to early Mesozoic) but showing only limited outward growth by crustal accretion, because of a repeated history of overthrust shortening during repeated phases of orogenesis

High Diagnostic Accuracy of Nitrite Test Paired with Urine Sediment can Reduce Unnecessary Antibiotic Therapy

Abstract: Background: Urinary tract infections (UTIs) are common bacterial infections dominated by lower UTI in women (LUTIW). Symptoms only are insufficient for diagnosis and accordingly, near patient diagnostic tests confidently confirming significant bacteriuria are desirable. The nitrite test (NIT) has low sensitivity, while bacterial and leukocyte counts disjunctively paired in urine sediment microscopy (SED) have high sensitivity. Similar symptomatic cure rates are found post antibiotic vs. placebo therapy in patients with negative cultures. Consequently, prescription on symptoms only implies unnecessary antibiotic therapy. Aims: to evaluate the diagnostic outcomes of NIT, SED and NIT disjunctively paired with SED (NIT+SED) vs. urine culture, with special focus on bladder incubation time (BIT), and to assess if NIT+SED can reduce unnecessary antibiotic therapy. Methods: A diagnostic, primary care, multicentre study including 1070 women with symptoms suggestive of lower UTI. Results: Significant bacteriuria was found in 77%. The BIT highly influenced the diagnostic outcomes and the optimal duration was 4h with sensitivity of 66, 90 and 95% for NIT, SED and NIT+SED, respectively. SED performed only in NIT negative specimens could reduce unnecessary antibiotics by 10% vs. prescription on symptoms only. The number needed to test with SED to reduce one unnecessary antibiotic course was five patients at BIT 4h and six patients at 3h or overall. Conclusion: The BIT highly influences the diagnostic outcomes with the highest accuracy of NIT+SED. Diagnosis of LUTIW with NIT+SED can reduce unnecessary antibiotic therapy and subsequently decrease antimicrobial resistance. Trial registration: The Swedish Medical Product Agency 1995 03 01:151:01783/94