Single nucleotide polymorphisms in the bovine leptin gene and their association with carcass and efficiency traits, and endocrine profiles, in female Angus cows

One hundred and fifty female Angus cattle were genotyped for the bovine leptin gene SNPs UASMS1, UASMS2, E2FB and E2JW. Net Feed Intake (NFI) Estimated Breeding Values (EBVs) and E2JW SNP data was also acquired from 169 Angus cattle that originated from Trangie Research Station, NSW, and were selected for a divergence in feed efficiency. The E2JW SNP was associated with NFI, NFI EBV and P8 fatness. The UASMS1 and UASMS2 SNPs were associated with circulating leptin concentrations. These particular associations have not been reported previously but similar associations have reported in North American studies. The inconsistent associations suggest that these SNPs are not good candidates for marker-assisted selection for NFI. Also, the investigation of associations with endocrine profiles that reflect body composition such as leptin, requires genotyping of a larger number of Australian cattle than was possible in this experiment

Vacuum effects in an asymptotically uniformly accelerated frame with a constant magnetic field

In the present article we solve the Dirac-Pauli and Klein Gordon equations in an asymptotically uniformly accelerated frame when a constant magnetic field is present. We compute, via the Bogoliubov coefficients, the density of scalar and spin 1/2 particles created. We discuss the role played by the magnetic field and the thermal character of the spectrum.Comment: 17 pages. RevTe

Background Thermal Contributions in Testing the Unruh Effect

We consider inertial and accelerated Unruh-DeWitt detectors moving in a background thermal bath and calculate their excitation rates. It is shown that for fast moving detectors such a thermal bath does not affect substantially the excitation probability. Our results are discussed in connection with a possible proposal of testing the Unruh effect in high energy particle accelerators.Comment: 13 pages, (REVTEX 3.0), 3 figures available upon reques

Energetics, forces, and quantized conductance in jellium modeled metallic nanowires

Energetics and quantized conductance in jellium modeled nanowires are investigated using the local density functional based shell correction method, extending our previous study of uniform in shape wires [C. Yannouleas and U. Landman, J. Phys. Chem. B 101, 5780 (1997)] to wires containing a variable shaped constricted region. The energetics of the wire (sodium) as a function of the length of the volume conserving, adiabatically shaped constriction leads to formation of self selecting magic wire configurations. The variations in the energy result in oscillations in the force required to elongate the wire and are directly correlated with the stepwise variations of the conductance of the nanowire in units of 2e^2/h. The oscillatory patterns in the energetics and forces, and the correlated stepwise variation in the conductance are shown, numerically and through a semiclassical analysis, to be dominated by the quantized spectrum of the transverse states at the narrowmost part of the constriction in the wire.Comment: Latex/Revtex, 11 pages with 5 Postscript figure

A 4 year observation of gastrointestinal nematode egg counts, nemabiomes and the benzimidazole resistance genotypes of Teladorsagia circumcincta on a Scottish sheep farm

Anthelmintic resistance threatens the sustainability of sheep production globally. Advice regarding strategies to reduce the development of anthelmintic resistance incorporates the outcomes of modelling exercises. Further understanding of gastrointestinal nematode species diversity, and population dynamics and genetics (which may vary between species) is required to refine these models; and field studies combining faecal egg outputs, species composition and resistance genetics are needed to calibrate them. In this study, faecal samples were taken from ewes and lambs on a commercial farm in south-eastern Scotland at approximately 3 t-4 week intervals between spring and autumn over a period of 4 years. Faecal egg counts were performed on these samples, and L3 were collected from pooled coprocultures. Deep amplicon sequencing was used to determine both the species composition of these L3 and the proportions of benzimidazole-resistant single nucleotide polymorphisms in the isotype-1 β-tubulin locus of the predominant species, Teladorsagia circumcincta L3. Despite consistent management throughout the study, the results show variation in gastrointestinal nematode species composition with time and between age groups, that was potentially associated with weather conditions. The F200Y benzimidazole resistance mutation is close to genetic fixation in the T. circumcincta population on this farm. There was no evidence of variation in isotype-1 β-tubulin single nucleotide polymorphisms frequency between age groups, and no genetic evidence of reversion to benzimidazole susceptibility, despite targeted benzimidazole usage. This study highlights the need to include speciation when investigating gastrointestinal nematode epidemiology and anthelmintic resistance, and serves as an example of how genetic data may be analysed alongside species diversity and faecal egg counts, when markers for other anthelmintic classes are identified

A first-principles approach to electrical transport in atomic-scale nanostructures

We present a first-principles numerical implementation of Landauer formalism for electrical transport in nanostructures characterized down to the atomic level. The novelty and interest of our method lies essentially on two facts. First of all, it makes use of the versatile Gaussian98 code, which is widely used within the quantum chemistry community. Secondly, it incorporates the semi-infinite electrodes in a very generic and efficient way by means of Bethe lattices. We name this method the Gaussian Embedded Cluster Method (GECM). In order to make contact with other proposed implementations, we illustrate our technique by calculating the conductance in some well-studied systems such as metallic (Al and Au) nanocontacts and C-atom chains connected to metallic (Al and Au) electrodes. In the case of Al nanocontacts the conductance turns out to be quite dependent on the detailed atomic arrangement. On the contrary, the conductance in Au nanocontacts presents quite universal features. In the case of C chains, where the self-consistency guarantees the local charge transfer and the correct alignment of the molecular and electrode levels, we find that the conductance oscillates with the number of atoms in the chain regardless of the type of electrode. However, for short chains and Al electrodes the even-odd periodicity is reversed at equilibrium bond distances.Comment: 14 pages, two-column format, submitted to PR

Production and detection of three-qubit entanglement in the Fermi sea

Building on a previous proposal for the entanglement of electron-hole pairs in the Fermi sea, we show how 3 qubits can be entangled without using electron-electron interactions. As in the 2-qubit case, this electronic scheme works even if the sources are in (local) thermal equilibrium -- in contrast to the photonic analogue. The 3 qubits are represented by 4 edge-channel excitations in the quantum Hall effect (2 hole excitations plus 2 electron excitations with identical channel index). The entangler consists of an adiabatic point contact flanked by a pair of tunneling point contacts. The irreducible 3-qubit entanglement is characterized by the tangle, which is expressed in terms of the transmission matrices of the tunneling point contacts. The maximally entangled Greenberger-Horne-Zeilinger (GHZ) state is obtained for channel-independent tunnel probabilities. We show how low-frequency noise measurements can be used to determine an upper and lower bound to the tangle. The bounds become tighter the closer the electron-hole state is to the GHZ state.Comment: 8 pages including 4 figures; [2017: fixed broken postscript figures

Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction

The purpose of this study was to investigate the acute effects of multi-joint resistance exercises (MJRE) with blood flow restriction on hormonal responses. Ten men participated in the study and underwent two experimental protocols in random order: four sets (30, 15, 15, and 15 reps, respectively) of MJRE (half squat and horizontal chest press) were performed with 20% of 1RM and a rest time between sets of 30 s, combined with intermittent blood flow restriction (LI + BFR protocol); and four sets (8, 8, 8, 20 reps, respectively) of the same MJRE performed with 75% of 1RM load (HI protocol), with a 90 s rest between the first three sets and 30 s between the third to the fourth set. Blood samples were collected before (PRE), immediately after (POST), and 15 min after the performance of MJRE (POST15). A time effect was observed for growth hormone (GH) and insulin-like-growth-factor-1-binding-protein-3 (IGFPB-3), but no protocol effects or interactions between protocol and times were observed (p > 0.05). There was no effect of either protocol or time (p > 0.05) on total testosterone, free testosterone, or cortisol concentrations. However, significant (p < 0.05) increases were observed in the GH serum concentrations of 2072.73% and 2278.5%, HI, and LI + BFR protocols, respectively, from the PRE to POST15 test. In addition, there was an increase of 15.30% and 13.29% in the IGFPB-3 concentrations (p < 0.05) from PRE to POST0 times for HI and LI + BFR protocols, respectively. Furthermore, there was a decrease of 6.17% and 11.54%, p = 0.00, between the times POST0 to POST15 in the IGFPB-3 for the HI and LI + BFR protocols, respectively. It is concluded that multi-joint resistance exercises combined with intermittent blood flow restriction seemed to promote acute hormonal responses in a manner similar to traditional exercise with high loads. Future studies may investigate whether chronic use of LI + BFR with MJRE may promote muscle hypertrophy