“Venid a suspirar al verde prado”: saudade e melancolia em uma canção ibérica (séc. XVI)

This article by employing the use of musical analysis, investigating the possibility of music porting an objective basis for the production of sensations, feelings and meanings. Thus, it is inscribed in the traditional discussion, often engendered by neo- Kantian and the Husserlian phenomenology, around the categorical joints involved in the subject-object relationship. The analyzed example is the Iberian anonymous “Venid a suspirar al verde prado”. Through its analysis, we concluded that the constitution's own musical time lie the foundations that sustain affective production and signifying that common sense attributes to the Iberian repertoire, especially the Portuguese songbook.O presente artigo, empregando o recurso da análise musical, investiga a possibilidade de a música portar uma base objetiva para a produção de sensações, sentimentos e significados. Desse modo, ele se inscreve na tradicional discussão, frequentemente engendrada pelo neo-kantismo e pea fenomenologia husserliana, em torno das articulações categóricas envolvidas na relação sujeito-objeto. O exemplo analisado é o anônimo ibérico Venid a suspirar al verde prado. Por meio de sua análise, pudemos concluir que na constituição do próprio tempo musical residem as bases que sustentam a produção afetiva e significadora que o senso comum atribui ao cancioneiro ibérico, sobretudo, ao cancioneiro portugu

Social impact bond feasibility study tackling migrants’ unemployment: capacitação4job

Capacitação4Job (C4Job) is a project of the Jesuit Refugee Service (JRS) that implements a solution to address the social problem of migrants’ unemployment. This thesis is the result of participating on the fourth Social Impact Bond (SIB) Research Program at Laboratório de Investimento Social and it assesses the feasibility of using a SIB to finance JRS to scale to Oporto and to expand its target population. In addition, this thesis aims at contributing towards mobilizing private investors and public entities to work together with an innovative solution for the employability of migrants

La Estética de la Interpretación de los sueños

Trata-se de um estudo filosófico sobre as tensões e articulações entre a Estética e a Lógica na A Interpretação dos Sonhos de Sigmund Freud (1856-1939). Procuramos demonstrar como Freud, nesse texto que é estratégico para o estabelecimento da práxis psicanalítica e que repercute nos movimentos artísticos contemporâneos, estabelece um método amparado no rigor da observação e da lógica e, ao mesmo tempo, chama em auxílio a este método noções provenientes da Estética, quais sejam, as noções de representação, de forma, de conteúdo e de unidade, parecendo contrariar, desse modo, a tradição filosófica idealista, que estipulara historicamente a distinção entre o inteligível e o sensível.This paper presents a philosophical study of the tensions and interconections between Aesthetics and Logic in The Interpretation of Dreams by Sigmund Freud (1856-1939). We wish to demonstrate how Freud in this text which is strategic for the establishment of psychoanalytic praxis and that resonates in contemporary artistic movements, establishes a method supported in the accuracy of observation and logic and, at the same time, invocates in aid to this method notions of representation, form, content and unit, seemingly opposing thus the idealist philosophical tradition, historically founded in the distinction between the intelligible and the sensible

La tormentosa relación entre las grasas y el desarrollo de la diabetes mellitus de tipo 2: actualizado: parte 1

En esta parte de la revisión se describe la relación funcional entre el metabolismo de los lípidos y los hidratos de carbono y su interdependencia, desde el ciclo glucosa-ácido grasos y la hipótesis portal de la insulinorresistencia a los nuevos conocimientos sobre los adipocitos marrones y beiges, con énfasis en el normal funcionamiento de un patrón endocrino cuya disfunción es clave en la fisiopatología de la DMT2 y la obesidad. Se discute la ectopia o el asiento de grasa en el tejido magro por incapacidad del tejido adiposo para seguir acopiando lípidos y la actividad endocrina del adipocito, con la producción de moléculas (adipoquinas) que influyen sobre los mecanismos inductores de insulinorresistencia (leptina, adiponectina, TNF-α, resistina, etc.) y disfunción de la célula beta. Se describen la disminución de la capacidad oxidativa en la cadena respiratoria mitocondrial y el renacer del concepto de lipogénesis de novo, ambas favoreciendo el acopie de lípido intracelular. En tejidos magros existen pequeñas reservas intracelulares de lípidos que mantienen la regulación de funciones esenciales, aunque si aparece una sobrecarga lipídica el fenómeno conduciría a una disfunción (lipotoxicidad) y a la muerte celular (lipoapoptosis). La tormentosa relación entre los lípidos y el islote de Langerhans va más allá del esfuerzo funcional que impone la insulinorresistencia periférica sobre la célula β, por efectos directos de los lípidos o de sus derivados sobre la función del islote pancreático. Sin déficit de insulina no se desarrolla diabetes.Fil: Costa Gil, José Esteban. Universidad Favaloro. Facultad de Medicina; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentin

The stormy relationship between fats and the development of type 2 diabetes mellitus: Updated. Part 2

En esta parte de la revisión se describe la relación funcional entre el metabolismo de los lípidos y los hidratos de carbono y su interdependencia, desde el ciclo glucosa-ácido grasos y la hipótesis portal de la insulinorresistencia a los nuevos conocimientos sobre los adipocitos marrones y beiges, con énfasis en el normal funcionamiento de un patrón endocrino cuya disfunción es clave en la fisiopatología de la DMT2 y la obesidad. Se discute la ectopia o el asiento de grasa en el tejido magro por incapacidad del tejido adiposo para seguir acopiando lípidos y la actividad endocrina del adipocito, con la producción de moléculas (adipoquinas) que influyen sobre los mecanismos inductores de insulinorresistencia (leptina, adiponectina, TNF-α, resistina, etc.) y disfunción de la célula beta. Se describen la disminución de la capacidad oxidativa en la cadena respiratoria mitocondrial y el renacer del concepto de lipogénesis de novo, ambas favoreciendo el acopie de lípido intracelular. En tejidos magros existen pequeñas reservas intracelulares de lípidos que mantienen la regulación de funciones esenciales, aunque si aparece una sobrecarga lipídica el fenómeno conduciría a una disfunción (lipotoxicidad) y a la muerte celular (lipoapoptosis). La tormentosa relación entre los lípidos y el islote de Langerhans va más allá del esfuerzo funcional que impone la insulinorresistencia periférica sobre la célula β, por efectos directos de los lípidos o de sus derivados sobre la función del islote pancreático. Sin déficit de insulina no se desarrolla diabetes.In this part of the review, the functional relationship between lipid and carbohydrate metabolisms and their interdependence is described, from the glucose-fatty acid cycle and the portal hypothesis of insulin resistance to the new knowledge on brown and beige adipocytes, with emphasis on the normal functioning of an endocrine pattern in which its dysfunction is a key factor in the pathophysiology of T2DM and obesity. Ectopic fat deposition in lean tissues due to the inability of the adipose tissue to continuously collect lipids and the endocrine activity of adipocytes is discussed. The production of molecules (adipokines) influencing some of the mechanisms involved in the development of insulin resistance (leptin, adiponectin, TNF-α, resistin, etc.) and beta cell dysfunction is also revisited. The decrease in the oxidative capacity in the mitochondrial respiratory chain and the rebirth of the concept of de novo lipogenesis are described, both effects favouring intracellular lipid accumulation. In lean tissues there are small intracellular lipid reserves that help to maintain the regulation of essential functions; however, when a lipid overload occurs the phenomenon could lead to severe cell dysfunction (lipotoxicity), and death (lipo-apoptosis). The stormy relationship between lipids and the Langerhans’ islets goes beyond the functional effort imposed by peripheral insulin-resistance on the β cells, either by the direct effect of lipids or by their derivatives on overall pancreatic islet function. Within a scenario of no insulin deficit, diabetes does not develop.Fil: Costa Gil, José Esteban. Universidad Favaloro. Facultad de Medicina; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentin

Análise do polimorfismo genético do Paracoccidioides brasiliensis e Paracoccidioides cerebriformis "Moore" pela técnica de amplificação aleatória do polimorfismo do DNA (RAPD) e sequenciamento do DNA ribossomal 28S: Paracoccidioides cerebriformis revisitado

Our purpose was to compare the genetic polymorphism of six samples of P. brasiliensis (113, 339, BAT, T1F1, T3B6, T5LN1), with four samples of P. cerebriformis (735, 741, 750, 361) from the Mycological Laboratory of the Instituto de Medicina Tropical de São Paulo, using Random Amplified Polymorphic DNA Analysis (RAPD). RAPD profiles clearly segregated P. brasiliensis and P. cerebriformis isolates. However, the variation on band patterns among P. cerebriformis isolates was high. Sequencing of the 28S rDNA gene showed nucleotide conservancy among P. cerebriformis isolates, providing basis for taxonomical grouping, and disclosing high divergence to P. brasiliensis supporting that they are in fact two distinct species. Moreover, DNA sequence suggests that P. cerebriformis belongs in fact to the Aspergillus genus.Nosso propósito foi comparar o polimorfismo genético de seis amostras de P. brasiliensis (113, 339, BAT, T1F1, T3B6, T5LN1), com quatro amostras de P. cerebriformis (735, 741, 750, 361) do laboratório de micologia do Instituto de Medicina Tropical de São Paulo, utilizando a técnica de Amplificação Aleatória do Polimorfismo de DNA (RAPD). O perfil de bandas do RAPD diferenciou claramente os isolados de P. brasiliensis de P. cerebriformis. Entretanto, ocorreu uma variação significativa no padrão de bandas das amostras de P. cerebriformis. O sequenciamento do gene ribossomal 28S revelou seqüências de nucleotídeos bastante conservadas entre os isolados de P. cerebriformis, fornecendo subsídio para o agrupamento taxonômico destas amostras, diferenciando estas de P. brasiliensis e mostrando que de fato são espécies distintas. A seqüência de DNA sugere que P. cerebriformis pertence ao gênero Aspergillus

Hornos hallados en el campamento romano de Cidadela (Sobrado dos Monxes, A Coruña)

Las excavaciones que, de manera ininterrumpida, se desarrollaron entre los años 2006 y 2010 nos han permitido conocer algo mejor el ordenamiento del antiguo campamento romano de Cidadela. Tres áreas han sido objeto de especiales atenciones durante las mismas: las edificaciones más occidentales de los latera praetorii, una nueva construcción frente a éstas al sur de la uia principalis y la muralla perimetral en su sector noroeste. En este último espacio se documentaron durante la campaña de 2009 los restos de una estructura que identificamos como un homo. La ampliación de la excavación durante el año 2010 trajo consigo el descubrimiento de un nuevo ejemplar que fue completamente exhumado entonces. Debido tanto a su localización "en el inteuallum" como al carácter militar del yacimiento ambos han sido interpretados como hornos de pan.The archaeological campaigns developed between the years 2006 and 2010 at the Roman fort of Cidadela have revealed a little bit more from its original planning. The efforts were focused in three areas: the western buildings of the latera praetorii; the structure which lays in front of them beside the southern edge of the uia principalis; and the defensive wall in its northwestern sector. In this area were located in 2009 the remains of a structure later identified as an oven. Further excavations here revealed the presence of another one oven which was completely exhumed in 2010. Due to their location "at the interuallum" and the military character of the site we have identified both them as bread ovens

A cable-driven robot for architectural constructions: a visual-guided approach for motion control and path-planning

Cable-driven robots have received some attention by the scientific community and, recently, by the industry because they can transport hazardous materials with a high level of safeness which is often required by construction sites. In this context, this research presents an extension of a cable-driven robot called SPIDERobot, that was developed for automated construction of architectural projects. The proposed robot is formed by a rotating claw and a set of four cables, enabling four degrees of freedom. In addition, this paper proposes a new Vision-Guided Path-Planning System (V-GPP) that provides a visual interpretation of the scene: the position of the robot, the target and obstacles location; and optimizes the trajectory of the robot. Moreover, it determines a collision-free trajectory in 3D that takes into account the obstacles and the interaction of the cables with the scene. A set of experiments make possible to validate the contribution of V-GPP to the SPIDERobot while operating in realistic working conditions, as well as, to evaluate the interaction between the V-GPP and the motion controlling system. The results demonstrated that the proposed robot is able to construct architectural structures and to avoid collisions with obstacles in their working environment. The V-GPP system localizes the robot with a precision of 0.006 m, detects the targets and successfully generates a path that takes into account the displacement of cables. Therefore, the results demonstrate that the SPIDERobot can be scaled up to real working conditions.This work is partly funded by the project PTDC/ ATP-AQI/5124/2012 - Robotic Technologies for Non-Standard Design and Construction in Architecture. This work is also financed by the ERDF European Regional Development Fund through the COMPETE Programme (operational programme for competitiveness) and by National Funds through the FCT Portuguese Foundation for Science and Technology within project “FCOMP - 01-0124-FEDER-022701”.info:eu-repo/semantics/publishedVersio

Riesgo de cáncer oral y marcadores moleculares

El aspecto clínico y en especial el grado de displasia que pueden presentar las lesiones precancerosas de la cavidad oral sugieren su capacidad potencial de malignización. Cada vez es más frecuente encontrar investigaciones orientadas hacia la búsqueda de nuevos marcadores, más específicos, que contribuyan a determinar el grado de alteración celular y permitan una mayor aproximación al conocimiento del grado de degeneración maligna de aquellas lesiones. En el presente trabajo de revisión se repasan los conceptos más actuales de estos marcadores, agrupados por familias: marcadores de crecimiento tumoral; marcadores de supresión tumoral y de respuesta antitumoral; marcadores de angiogénesis; marcadores de invasión tumoral y de potencial metastatizante; marcadores celulares de superficie; marcadores intracelulares; marcadores derivados del ácido araquidónico y marcadores enzimáticos.The clinical appearance and, especially, the degree of dysplasia that may be shown by pre-cancerous lesions in the oral cavity suggest a potential for malignisation. An increasing number of studies are seeking new, more specific markers that would help to determine the degree of cell alteration and enable a better understanding of the degree of malignant degeneration of these cells. The present review considers the most recent findings for these markers, grouping them into families: tumour growth markers; markers of tumour suppression and anti-tumour response; angiogenesis markers; markers of tumour invasion and metastatic potential; cell surface markers; intracellular markers; markers derived from arachidonic acid; and enzymatic markers