Community-based malaria screening and treatment for pregnant women receiving standard intermittent preventive treatment with sulfadoxine-pyrimethamine: a multicentre (The Gambia, Burkina Faso and Benin) cluster randomised controlled trial

Background We investigated whether adding community scheduled malaria screening and treatment (CSST) with artemether-lumefantrine by community health workers (CHWs) to standard intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) would improve maternal and infant health. Methods In this 2-arm cluster-randomized, controlled trial, villages in Burkina Faso, The Gambia, and Benin were randomized to receive CSST plus IPTp-SP or IPTp-SP alone. CHWs in the intervention arm performed monthly CSST during pregnancy. At each contact, filter paper and blood slides were collected, and at delivery, a placental biopsy was collected. Primary and secondary endpoints were the prevalence of placental malaria, maternal anemia, maternal peripheral infection, low birth weight, antenatal clinic (ANC) attendance, and IPTp-SP coverage. Results Malaria infection was detected at least once for 3.8% women in The Gambia, 16.9% in Benin, and 31.6% in Burkina Faso. There was no difference between study arms in terms of placenta malaria after adjusting for birth season, parity, and IPTp-SP doses (adjusted odds ratio, 1.06 [95% confidence interval, .78–1.44]; P = .72). No difference between the study arms was found for peripheral maternal infection, anemia, and adverse pregnancy outcomes. ANC attendance was significantly higher in the intervention arm in Burkina Faso but not in The Gambia and Benin. Increasing number of IPTp-SP doses was associated with a significantly lower risk of placenta malaria, anemia at delivery, and low birth weight. Conclusions Adding CSST to existing IPTp-SP strategies did not reduce malaria in pregnancy. Increasing the number of IPTp-SP doses given during pregnancy is a priority. Clinical Trials Registration NCT01941264; ISRCTN37259296

Leading nucleon and inelasticity in hadron-nucleus interactions

We present in this paper a calculation of the average proton-nucleus ine- lasticity. Using an Iterative Leading Particle Model and the Glauber model, we relate the leading particle distribution in nucleon-nucleus interactions with the respective one in nucleon-proton collisions. To describe the leading particle distribution in nucleon-proton collisions, we use the Regge-Mueller formalism. To appear in Journal of Physics G.Comment: 11 pages, 2 figure

Constraints on growth index parameters from current and future observations

We use current and future simulated data of the growth rate of large scale structure in combination with data from supernova, BAO, and CMB surface measurements, in order to put constraints on the growth index parameters. We use a recently proposed parameterization of the growth index that interpolates between a constant value at high redshifts and a form that accounts for redshift dependencies at small redshifts. We also suggest here another exponential parameterization with a similar behaviour. The redshift dependent parametrizations provide a sub-percent precision level to the numerical growth function, for the full redshift range. Using these redshift parameterizations or a constant growth index, we find that current available data from galaxy redshift distortions and Lyman-alpha forests is unable to put significant constraints on any of the growth parameters. For example both $\Lambda$CDM and flat DGP are allowed by current growth data. We use an MCMC analysis to study constraints from future growth data, and simulate pessimistic and moderate scenarios for the uncertainties. In both scenarios, the redshift parameterizations discussed are able to provide significant constraints and rule out models when incorrectly assumed in the analysis. The values taken by the constant part of the parameterizations as well as the redshift slopes are all found to significantly rule out an incorrect background. We also find that, for our pessimistic scenario, an assumed constant growth index over the full redshift range is unable to rule out incorrect models in all cases. This is due to the fact that the slope acts as a second discriminator at smaller redshifts and therefore provide a significant test to identify the underlying gravity theory.Comment: 13 pages, 5 figures, matches JCAP accepted versio