Not all Online Sexual Activities Are the Same

Young people's use and participation in online sexual activities (OSA) has increased in the past two decades and has changed their behavior in the area of sexuality. The existing literature has some important limitations, concerning the assessment of the construct and its orientation toward problematic use, while ignoring its healthy use or social participation and its relationship with well-being. The main objective of this study was to analyze the relationships between the three types of OSA (compulsive, isolated, and social) proposed by Delmonico and Miller, as well as offline sexual behavior, and psychosexual well-being. It was also necessary to evaluate the factor structure of the Internet Sexual Screening Test (ISST). Participants were 1, 147 university students of both sexes, aged between 18 and 26 years, who completed a battery of online questionnaires. The main finding of the study is that, when controlling for other online sexual behavior, different types of OSA evaluated relate differently to offline sexual behavior and to psychosexual well-being, and that most young people made healthy use and participation of OSA. It also presents a new structure of the ISST. The discussion emphasizes the need to recognize the positive consequences of OSA to implement programs for the promotion of sexual health

A preliminary study about treg cells phenotypic alteration

Las células T reguladoras son una subpoblación de los linfocitos T CD4+ de gran importancia en el establecimiento y mantenimiento de la tolerancia y la homeostasis del sistema inmune. Muchos estudios han analizado la frecuencia de las Treg en pacientes infectados por VIH. Sin embargo, los resultados no son concluyentes y existe una gran controversia sobre el papel que juegan las Treg en el curso de la infección. Recientemente se ha demostrado que el VIH puede infectar las células Treg. Trabajos previos de nuestro grupo demuestran que las Treg son susceptibles de infección por el VIH disminuyendo la expresión del Foxp3 en las células infectadas. Este fenómeno produce una alteración en la capacidad supresora de las células Treg. El objetivo de éste estudio es corroborar dicho comportamiento in vivo y determinar el fenotipo de las Treg en pacientes infectados por VIH. Los resultados preliminares indican que efectivamente la frecuencia de células Foxp3+ es inferior en los pacientes infectados por VIH que en los individuos sanos. El estudio sigue en curso para recopilar un número suficiente de muestras que permitan confirmar estos resultados. Este estudio permitirá conocer mejor el papel de las Treg en el curso de la infección por VIHRegulatory T cells (Treg) are a subpopulation of CD4+ T cells that play a crucial role in establishing and maintaining self-tolerance and immune homeostasis. Many studies have explored the frequency of Treg in HIV infected patients. However, there are controversial findings about the role of these cells in the HIV infection. Nowadays, different studies have showed that Treg cells are susceptible to the HIV infection. Our in vitro data has showed that HIV infects Treg and produces a downregulation of Foxp3 expression. This phenomenon also leads Treg cells to a loss of their immune suppressive capacity. The aim of this study is to corroborate if this behavior also occurs in vivo and determine the Treg phenotype in HIVinfected patients. Preliminary results indicate that frequency of Foxp3+ cells is lower in HIVinfected patients than in healthy volunteers. At present, we are recovering enough number of samples to confirm these results. A better understanding of these cells could serve for the effective exploitation of their suppressive functions for clinical benefit

Construcción del conocimiento didáctico del contenido biológico en formación inicial de profesores

Presentamos la sistematización de los datos obtenidos a partir de los documentos que presentaron dos grupos de futuros profesores de Biología, a lo largo de un semestre, al diseñar Unidades Didácticas para la enseñanza de dos temáticas relacionadas con el auto-mantenimiento de los organismos. Analizamos los referentes de los docentes en formación acerca del Conocimiento Didáctico del Contenido Biológico (contemplamos 9 categorías de investigación) y los cambios de los mismos durante el proceso formativo en el que los estudiantes-profesores realizaron la propuesta

Topiramate in the treatment of severe myoclonic epilepsy in infancy

AbstractThe aim of this study was to assess the effectiveness of topiramate (TPM) as an add-on regimen in reducing seizure rate in a population sample of patients diagnosed with severe myoclonic epilepsy in infancy (SME). Eighteen patients were evaluated. The mean observation time was 10.5 months (range, 6–18 months). Seizure frequency and type were recorded. Topiramate was administered as an add-on regimen at a starting dose of 1 mg kg−1and titrated to a maximum of 6–8 mg per kg per day. Different escalation rates were used, mainly weekly or fortnightly increments of dose. Three patients (16.6%) became seizure free, and 10 (55.6%) had a >50% reduction in seizure frequency: six of them (22.2%) achieved a reduction greater than 75%. Side-effects were observed in nine patients , eight with a weekly titration schedule and one with a fortnightly schedule. TPM is effective as adjunctive therapy for SME. Side-effects were mild and transient, generally related to rapid dosage titration

Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes

<p>Abstract</p> <p>Background</p> <p>Oxidative stress (OxS) has recently been linked with osteoporosis; however, we do not know the influence of OxS as an independent risk factor for this disease.</p> <p>Methods</p> <p>We conducted a case-control study in 94 subjects ≥60 years of age, 50 healthy and 44 with osteoporosis. We measured total antioxidant status, plasma lipid peroxides, antioxidant activity of superoxide dismutase and glutathione peroxidase (GPx), and calculated the SOD/GPx ratio. Bone mineral density was obtained at the peripheral DXA in calcaneus using a portable Norland Apollo Densitometer^®. Osteoporosis was considered when subjects had a BMD of 2.5 standard deviations or more below the mean value for young adults.</p> <p>Results</p> <p>GPx antioxidant activity was significantly lower in the group of subjects with osteoporosis in comparison with the group of healthy subjects (<it>p </it>< 0.01); in addition, the SOD/GPx ratio was significantly higher in the group of individuals with osteoporosis (<it>p </it>< 0.05). In logistic regression analysis, we found OxS to be an independent risk factor for osteoporosis (odds ratio [OR] = 2.79; 95% confidence interval [95% CI] = 1.08–7.23; <it>p </it>= 0.034).</p> <p>Conclusion</p> <p>Our findings suggest that OxS is an independent risk factor for osteoporosis linked to increase of SOD/GPx ratio.</p

Diversity and neocolonialism in Big Data research: Avoiding extractivism while struggling with paternalism

The extractive logic of Big Data-driven technology and knowledge production has raised serious concerns. While most criticism initially focused on the impacts on Western societies, attention is now increasingly turning to the consequences for communities in the Global South. To date, debates have focused on private-sector activities. In this article, we start from the conviction that publicly funded knowledge and technology production must also be scrutinized for their potential neocolonial entanglements. To this end, we analyze the dynamics of collaboration in an European Union-funded research project that collects data for developing a social platform focused on diversity. The project includes pilot sites in China, Denmark, the United Kingdom, India, Italy, Mexico, Mongolia, and Paraguay. We present the experience at four field sites and reflect on the project’s initial conception, our collaboration, challenges, progress, and results. We then analyze the different experiences in comparison. We conclude that while we have succeeded in finding viable strategies to avoid contributing to the dynamics of unilateral data extraction as one side of the neocolonial circle, it has been infinitely more difficult to break through the much more subtle but no less powerful mechanisms of paternalism that we find to be prevalent in data-driven North–South relations. These mechanisms, however, can be identified as the other side of the neocolonial circle.</p

Influencia del carbón activo en la biodisponibilidad II

Proceeding in the same form as in part 1, in the present work we set up the study of the influence that the active coals mentioned in the former part exert upon the absorption of pyridoxine hidrochloride. The same as before, we observe different behaviour to both coals. Relating the results obtained with the given drugs, we find that the decrease of the bio-availability is more evident in the case of phenphormine chlorhydrate than that of piridoxine.Procediendo de igual manera que en la parte 1, se realiza en este trabajo el estudio de la influencia que sobre la absorción del clorhidrato de piridoxina ejercen los carbones activos mencionados en la parte anterior. Al igual que allí, se observa distinto comportamiento con ambos carbones. Relacionando los resultados obtenidos con los citados fármacos, se comprueba que la disminución en la biodisponibilidad es más acentuada en el caso del clorhidrato de fenformina que para el de piridoxina

Influencia del carbón activo en la biodisponibilidad de fármacos. I

Utilizando el Simulador de Absorción Sartorius SM 16750 y siguiendo el método de Stricker, se realiza el estudio de la influencia que sobre la absorción del clorhidrato de fenformina ejerce el carbón activo. Para ello se han usado dos carbones con distinto tiempo de activación. Se comprueba, por los datos obtenidos, que la biodisponibilidad del fármaco es diferente con ambos carbones.Using the SM 16750 Sartorius Absorption Simulator and following the Stricker's means, we carry out the study of the influence that the active coal exerts upon the absorption of phenformin hydrochloride. For tnat, two different activation time coals have been used. We prove, from the obtained data, that the bioavailability of the drug is different to both coals

Influencia del carbón activo en la biodisponibilidad de fármacos. I

Using the SM 16750 Sartorius Absorption Simulator and following the Stricker's means, we carry out the study of the influence that the active coal exerts upon the absorption of phenformin hydrochloride. For that, two different activation time coals have been used. We prove, from the obtained data, that the bioavailability of the drug is different to both coals.Utilizando el Simulador de Absorción Sartorius SM 16750 y siguiendo el método de Stricker, se realiza el estudio de la influencia que sobre la absorción del clorhidrato de fenformina ejerce el carbón activo. Para ello se han usado dos carbones con distinto tiempo de activación. Se comprueba, por los datos obtenidos, que la biodisponibilidad del fármaco es diferente con ambos carbones

Preparación y caracterización de un carbón activo a partir de madera de olivo

Active carbón were prepared by activating olive wood under a flow of air and carbón dioxide at 1073º K. The final products have been characterized by adsorption of N2 a 77º K, CO2 at 273º K and 293º K, p-nitrophenol at 293º K, and by rnercury porosimetry. A developmente of micro, meso and macroporosiy takes place over the activation.Se han preparado carbones activos por activación de madera de olivo con aire y posteriormente con CO2 a 1073º K. Las muestras han sido caracterizadas por adsorción de N2 a 77º K, CO2 a 273º K, p-nitrofenol a 293º K Y por porosimetría de mercurio. Durante la activación se produce un desarrollo de la micro, meso y macroporosidad de las muestras