A singularidade do discurso trobadoresco de Alfonso X

No presente traballo destácase o cancioneiro profano de Alfonso X como a produción máis persoal do monarca, no que se pode percibir a voz propia dun trobador que se acomoda aos canons da tradición trobadoresca europea, ao mesmo tempo que se erixe en cabeza visible dunha corte que se consolida como o espazo más dinámico da lírica trobadoresca peninsular. Para iso analízase o labor de acollida da corte alfonsí das correntes literarias foráneas que logo traslada a súa propia obra, as circunstancias que explican que a súa poética sexa escrita en galego, e as particularidades do seu cancioneiro trobadoresco. O corpus presenta unha complexa tradición manuscrita e uns problemas codicolóxicos, que suscitan aínda hoxe debates entre a crítica (como a  fixación e establecemento dos textos). O estudo das súas cantigas mostra que o discurso trobadoresco alfonsí sobresae polo dominio do autor das técnicas marcadas pola escola, así como pola aguda e persoal percepción da sociedade e dos acontecementos históricos do momento

Screening for extracts with insect antifeedant properties in native plants from central Argentina

Se evaluaron los extractos etanólicos obtenidos de las partes aéreas de 64 plantas de la región Central de Argentina, como antialimentarios de insectos mediante ensayos de elección, contra Epilachna paenulata (Coleoptera: Coccinellidae). Los extractos derivados de Achyrocline satureioides (Asteraceae), Baccharis coridifolia (Asteraceae), Baccharis flabellata (Asteraceae), Ruprechtia apetala (Polygonaceae) y Vernonanthura nudiflora (Asteraceae) mostraron mas de 97% de inhibición de la alimentación de E. paenulata a 100 μg/cm2. Estos extractos fueron posteriormente evaluados en su efectividad contra Spodoptera frugiperda (Lepidoptera: Noctuidae). Todos ellos, con excepción del extracto de A. satureioides, afectaron negativamente el comportamiento alimentario de S. frugiperda a 100 μg/cm2.Ethanol extracts obtained from aerial parts of 64 native plants from Central Argentina were tested for their insect antifeedant activity against Epilachna paenulata (Coleoptera: Coccinellidae) by choice test. Extracts derived from Achyrocline satureioides (Asteraceae), Baccharis coridifolia (Asteraceae), Baccharis flabellata (Asteraceae), Ruprechtia apetala (Polygonaceae) and Vernonanthura nudiflora (Asteraceae), showed more than 97% inhibition of the feeding of E. paenulata at 100 μg/cm2 . These active extracts were further evaluated for their effectiveness against Spodoptera frugiperda (Lepidoptera: Noctuidae). All these extracts except for that derived from A. satureioides, negatively influenced the feeding behavior of S. frugiperda at 100 μg/cm2 .Fil: del Corral, Soledad. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diaz Napal, Georgina Natalia. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zaragoza, Mariano. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Carpinella, Maria Cecilia. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palacios, Sara Maria. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Evaluación de la actividad antialimentaria de insectos en extractos de plantas nativas del centro de Argentina

Se evaluaron los extractos etanólicos obtenidos de las partes aéreas de 64 plantas de la región Central de Argentina, como antialimentarios de insectos mediante ensayos de elección, contra Epilachna paenulata (Coleoptera: Coccinellidae). Los extractos derivados de Achyrocline satureioides (Asteraceae), Baccharis coridifolia (Asteraceae), Baccharis flabellata (Asteraceae), Ruprechtia apetala (Polygonaceae) y Vernonanthura nudiflora (Asteraceae) mostraron mas de 97% de inhibición de la alimentación de E. paenulata a 100 ug/cm2. Estos extractos fueron posteriormente evaluados en su efectividad contra Spodoptera frugiperda (Lepidoptera: Noctuidae). Todos ellos, con excepción del extracto de A. satureioides, afectaron negativamente el comportamiento alimentario de S. frugiperda a 100 ug/cm2

Application of Model-driven engineering to multi-agent systems: a language to model behaviors of reactive agents

Many users of multi-agent systems (MAS) are very commonly disinclined to model and simulate using current MAS platforms. More specifically, modeling the dynamics of a system (in particular the agents' behaviors) is very often a challenge to MAS users. This issue is more often observed in the domain of socio-ecological systems (SES), because SES domain experts are rarely programmers. Indeed, the majority of MAS platforms were not conceived taking into consideration domain-experts who are non-programmers. Most current MAS tools are not dedicated to SES, or nor do they possess an easily understandable formalism to represent the behaviors of agents. Moreover, because it is platform-dependent, a model realized in a given MAS platform cannot be properly used on another platform due to incompatibility between MAS platforms. To overcome these limitations, we propose a domain-specific language (DSL) to describe the behaviors of reactive agents, regardless of the MAS platform used for simulation. To achieve this result, we used model-driven engineering (MDE), an approach that provides tools to develop DSLs from a meta-model (abstract syntax), textual editors with syntax highlighting (for the concrete syntax) and code generation capabilities (for source-code generation of a model). As a result, we implemented a language and a textual editor that allow SES domain experts to describe behaviors in three different ways that are close to their natural expression: as equations when they are familiar with these, as a sequence of activities close to natural language or as an activity diagram to represent decisions and a sequence of behaviors using a graphic formalism. To demonstrate interoperability, we also developed code generators targeting two different MAS platforms (Cormas and Netlogo). We tested the code generators by implementing two SES models with the developed DSL. The generated code was targeted to both MAS platforms (Cormas and Netlogo), and successfully simulated in one of them. We conclude that the MDE approach provides adequate tools to develop DSL and code generators to facilitate MAS modeling and simulation by non-programmers. Concerning the DSL developed, although the behavioral aspect of MAS simulation is part of the complexity of modeling in MAS, there are still other essential aspects of model and simulation of MAS that are yet to be explored, such as model initialization and points of view on the model simulated worl

Universality Classes in Isotropic, Abelian and non-Abelian, Sandpile Models

Universality in isotropic, abelian and non-abelian, sandpile models is examined using extensive numerical simulations. To characterize the critical behavior we employ an extended set of critical exponents, geometric features of the avalanches, as well as scaling functions describing the time evolution of average quantities such as the area and size during the avalanche. Comparing between the abelian Bak-Tang-Wiesenfeld model [P. Bak, C. Tang and K. Wiensenfeld, Phys. Rev. Lett. 59, 381 (1987)], and the non-abelian models introduced by Manna [S. S. Manna, J. Phys. A. 24, L363 (1991)] and Zhang [Y. C. Zhang, Phys. Rev. Lett. 63, 470 (1989)] we find strong indications that each one of these models belongs to a distinct universality class.Comment: 18 pages of text, RevTeX, additional 8 figures in 12 PS file

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts

Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease. We therefore investigated the direct effect of FGF21 on cardio-protection in obese and lean hearts in response to ischemia. Methods and Results: FGF21, FGF21-receptor 1 (FGFR1) and beta-Klotho (βKlotho) were expressed in rodent, human hearts and primary rat cardiomyocytes. Cardiac FGF21 was expressed and secreted (real time RT-PCR/western blot and ELISA) in an autocrine-paracrine manner, in response to obesity and hypoxia, involving FGFR1-βKlotho components. Cardiac-FGF21 expression and secretion were increased in response to global ischemia. In contrast βKlotho was reduced in obese hearts. In isolated adult rat cardiomyocytes, FGF21 activated PI3K/Akt (phosphatidylinositol 3-kinase/Akt), ERK1/2(extracellular signal-regulated kinase) and AMPK (AMP-activated protein kinase) pathways. In Langendorff perfused rat [adult male wild-type wistar] hearts, FGF21 administration induced significant cardio-protection and restoration of function following global ischemia. Inhibition of PI3K/Akt, AMPK, ERK1/2 and ROR-α (retinoic-acid receptor alpha) pathway led to significant decrease of FGF21 induced cardio-protection and restoration of cardiac function in response to global ischemia. More importantly, this cardio-protective response induced by FGF21 was reduced in obesity, although the cardiac expression profiles and circulating FGF21 levels were increased. Conclusion: In an ex vivo Langendorff system, we show that FGF21 induced cardiac protection and restoration of cardiac function involving autocrine-paracrine pathways, with reduced effect in obesity. Collectively, our findings provide novel insights into FGF21-induced cardiac effects in obesity and ischemia

HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features.

Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83 y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL

Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized with COVID-19: A Randomized Clinical Trial

Importance Hospitalized patients with COVID-19 pneumonia have high rates of morbidity and mortality. Objective To assess the efficacy of colchicine in hospitalized patients with COVID-19 pneumonia. Design, Setting, and Participants The Estudios Clínicos Latino América (ECLA) Population Health Research Institute (PHRI) COLCOVID trial was a multicenter, open-label, randomized clinical trial performed from April 17, 2020, to March 28, 2021, in adults with confirmed or suspected SARS-CoV-2 infection followed for up to 28 days. Participants received colchicine vs usual care if they were hospitalized with COVID-19 symptoms and had severe acute respiratory syndrome or oxygen desaturation. The main exclusion criteria were clear indications or contraindications for colchicine, chronic kidney disease, and negative results on a reverse transcription–polymerase chain reaction test for SARS-CoV-2 before randomization. Data were analyzed from June 20 to July 25, 2021. Interventions Patients were assigned in a 1:1 ratio to usual care or usual care plus colchicine. Colchicine was administered orally in a loading dose of 1.5 mg immediately after randomization, followed by 0.5 mg orally within 2 hours of the initial dose and 0.5 mg orally twice a day for 14 days or discharge, whichever occurred first. Main Outcomes and Measures The first coprimary outcome was the composite of a new requirement for mechanical ventilation or death evaluated at 28 days. The second coprimary outcome was death at 28 days. Results A total of 1279 hospitalized patients (mean [SD] age, 61.8 [14.6] years; 449 [35.1%] women and 830 [64.9%] men) were randomized, including 639 patients in the usual care group and 640 patients in the colchicine group. Corticosteroids were used in 1171 patients (91.5%). The coprimary outcome of mechanical ventilation or 28-day death occurred in 160 patients (25.0%) in the colchicine group and 184 patients (28.8%) in the usual care group (hazard ratio [HR], 0.83; 95% CI, 0.67-1.02; P = .08). The second coprimary outcome, 28-day death, occurred in 131 patients (20.5%) in the colchicine group and 142 patients (22.2%) in the usual care group (HR, 0.88; 95% CI, 0.70-1.12). Diarrhea was the most frequent adverse effect of colchicine, reported in 68 patients (11.3%). Conclusions and Relevance This randomized clinical trial found that compared with usual care, colchicine did not significantly reduce mechanical ventilation or 28-day mortality in patients hospitalized with COVID-19 pneumonia.Fil: Diaz, Rafael. Estudios Clínicos Latino América; Argentina. Instituto Cardiovascular de Rosario; ArgentinaFil: Orlandini, Andrés. Estudios Clínicos Latino América; Argentina. Instituto Cardiovascular de Rosario; ArgentinaFil: Castellana, Noelia. Estudios Clínicos Latino América; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Caccavo, Alberto. Provincia de Buenos Aires. Dirección General de Cultura y Educación. Universidad Provincial del Sudoeste; ArgentinaFil: Corral, Pablo. Universidad FASTA "Santo Tomas de Aquino"; ArgentinaFil: Corral, Gonzalo. Infectología Clínica de Mayo; ArgentinaFil: Chacón, Carolina. Estudios Clínicos Latino América; Argentina. Universidad Abierta Interamericana; Argentina. Unidad Coronaria de Sanatorio Delta de Rosario; Argentina. Comite de Epidemiologia y Prevención Cardiovascular de la Federación Argentina de Cardiologia; ArgentinaFil: Lamelas, Pablo. McMaster University; Canadá. Instituto Cardiovascular de Buenos Aires; ArgentinaFil: Botto, Fernando. Instituto Cardiovascular de Buenos Aires; ArgentinaFil: Díaz, María Luz. Estudios Clínicos Latino América; Argentina. Instituto Cardiovascular de Rosario; ArgentinaFil: Domínguez, Juan Manuel. Estudios Clínicos Latino América; Argentina. Instituto Cardiovascular de Rosario; ArgentinaFil: Pascual, Andrea. Estudios Clínicos Latino América; ArgentinaFil: Rovito, Carla. Estudios Clínicos Latino América; ArgentinaFil: Galatte, Agustina. Estudios Clínicos Latino América; ArgentinaFil: Scarafia, Franco. Estudios Clínicos Latino América; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Sued, Omar. Fundación Huésped; ArgentinaFil: Gutierrez, Omar. Ministerio de Salud de Jujuy; ArgentinaFil: Jolly, Sanjit S.. McMaster University; CanadáFil: Miró, José M.. Universidad de Barcelona; EspañaFil: Eikelboom, John. McMaster University; CanadáFil: Loeb, Mark. McMaster University; CanadáFil: Maggioni, Aldo Pietro. Associazione Nazionale Medici Cardiologi Ospedalieri Research Center; ItaliaFil: Bhatt, Deepak L.. Brigham and Women’s Hospital; Estados Unidos. Harvard Medical School; Estados UnidosFil: Yusuf, Salim. McMaster University; CanadáFil: Lopez, Lorena. No especifíca;Fil: Leon de la Fuente, Ricardo Alfonso. Gobierno de la Provincia de Salta. Ministerio de Salud Pública. Hospital Papa Francisco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Forciniti, Cristian C. G.. No especifíca;Fil: Colombo, Hugo. No especifíca;Fil: Sabas, Nicolas. No especifíca;Fil: Pilón, Leonardo. No especifíca;Fil: Steren, Adriana P.. No especifíca