4 research outputs found
The Italian policy of mandating SARS-CoV-2 vaccination for healthcare workers: Analysis of the policy processes and preliminary outcomes
Surgical site infection prevention through bundled interventions in hip replacement surgery: A systematic review
A cross-sectional study of SARS-CoV-2 seropositivity among healthcare workers and residents of long-term facilities in Italy, January 2021
Longâterm care facilities (LTCFs) are highârisk settings for SARSâCoVâ2 infection. This study aimed to describe SARSâCoVâ2 seropositivity among residents of LTCFs and healthâcare workers (HCWs). Subjects were recruited in January 2021 among unvaccinated HCWs of LTCFs and hospitals and residents of LTCFs in Northern Italy. Information concerning previous SARSâCoVâ2 infections and a sample of peripheral blood were collected. AntiâS SARSâCoVâ2 IgG antibodies were measured using the EUROIMMUN AntiâSARSâCoVâ2 QuantiVac ELISA kit (EUROIMMUN Medizinische Labordiagnostika AG). For subjects with previous COVIDâ19 infection, gender, age, type of subject (HCW or resident), and time between last positive swab and blood draw were considered as possible determinants of two outcomes: the probability to obtain a positive serological result and antibody titer. Six hundred and fiftyâeight subjects were enrolled. 56.1% of all subjects and 65% of residents presented positive results (overall median antibody titer: 31.0âRU/ml). Multivariable models identified a statistically significant 4% decrease in the estimated antibody level for each 30âday increase from the last positive swab. HCWs were associated with significant odds for seroreversion over time (OR: 0.926 for every 30 days, 95% CI: 0.860â0.998), contrary to residents (OR: 1.059, 95% CI: 0.919â1.22). Age and gender were not factors predicting seropositivity over time. Residents could have a higher probability of maintaining a seropositive status over time compared to HCWs