179 research outputs found
Thermal Giant Gravitons
We study the giant graviton solution as the AdS_5 X S^5 background is heated
up to finite temperature. The analysis employs the thermal brane probe
technique based on the blackfold approach. We focus mainly on the thermal giant
graviton corresponding to a thermal D3-brane probe wrapped on an S^3 moving on
the S^5 of the background at finite temperature. We find several interesting
new effects, including that the thermal giant graviton has a minimal possible
value for the angular momentum and correspondingly also a minimal possible
radius of the S^3. We compute the free energy of the thermal giant graviton in
the low temperature regime, which potentially could be compared to that of a
thermal state on the gauge theory side. Moreover, we analyze the space of
solutions and stability of the thermal giant graviton and find that, in
parallel with the extremal case, there are two available solutions for a given
temperature and angular momentum, one stable and one unstable. In order to
write down the equations of motion, action and conserved charges for the
thermal giant graviton we present a slight generalization of the blackfold
formalism for charged black branes. Finally, we also briefly consider the
thermal giant graviton moving in the AdS_5 part.Comment: v1: 32 pages + 11 pages appendices, 13 figures, v2: typos fixed in
Sec.2 and other misprints, references adde
Holographic three-point functions of giant gravitons
Working within the AdS/CFT correspondence we calculate the three-point
function of two giant gravitons and one pointlike graviton using methods of
semiclassical string theory and considering both the case where the giant
gravitons wrap an S^3 in S^5 and the case where the giant gravitons wrap an S^3
in AdS_5. We likewise calculate the correlation function in N=4 SYM using two
Schur polynomials and a single trace chiral primary. We find that the gauge and
string theory results have structural similarities but do not match perfectly,
and interpret this in terms of the Schur polynomials' inability to interpolate
between dual giant and pointlike gravitons.Comment: 21 page
Strings on Bubbling Geometries
We study gauge theory operators which take the form of a product of a trace
with a Schur polynomial, and their string theory duals. These states represent
strings excited on bubbling AdS geometries which are dual to the Schur
polynomials. These geometries generically take the form of multiple annuli in
the phase space plane. We study the coherent state wavefunction of the lattice,
which labels the trace part of the operator, for a general Young tableau and
their dual description on the droplet plane with a general concentric ring
pattern. In addition we identify a density matrix over the coherent states on
all the geometries within a fixed constraint. This density matrix may be used
to calculate the entropy of a given ensemble of operators. We finally recover
the BMN string spectrum along the geodesic near any circle from the ansatz of
the coherent state wavefunction.Comment: 41 pages, 12 figures, published version in JHE
Set optimization - a rather short introduction
Recent developments in set optimization are surveyed and extended including
various set relations as well as fundamental constructions of a convex analysis
for set- and vector-valued functions, and duality for set optimization
problems. Extensive sections with bibliographical comments summarize the state
of the art. Applications to vector optimization and financial risk measures are
discussed along with algorithmic approaches to set optimization problems
Assessing the accuracy of an inter-institutional automated patient-specific health problem list
<p>Abstract</p> <p>Background</p> <p>Health problem lists are a key component of electronic health records and are instrumental in the development of decision-support systems that encourage best practices and optimal patient safety. Most health problem lists require initial clinical information to be entered manually and few integrate information across care providers and institutions. This study assesses the accuracy of a novel approach to create an inter-institutional automated health problem list in a computerized medical record (MOXXI) that integrates three sources of information for an individual patient: diagnostic codes from medical services claims from all treating physicians, therapeutic indications from electronic prescriptions, and single-indication drugs.</p> <p>Methods</p> <p>Data for this study were obtained from 121 general practitioners and all medical services provided for 22,248 of their patients. At the opening of a patient's file, all health problems detected through medical service utilization or single-indication drug use were flagged to the physician in the MOXXI system. Each new arising health problem were presented as 'potential' and physicians were prompted to specify if the health problem was valid (Y) or not (N) or if they preferred to reassess its validity at a later time.</p> <p>Results</p> <p>A total of 263,527 health problems, representing 891 unique problems, were identified for the group of 22,248 patients. Medical services claims contributed to the majority of problems identified (77%), followed by therapeutic indications from electronic prescriptions (14%), and single-indication drugs (9%). Physicians actively chose to assess 41.7% (n = 106,950) of health problems. Overall, 73% of the problems assessed were considered valid; 42% originated from medical service diagnostic codes, 11% from single indication drugs, and 47% from prescription indications. Twelve percent of problems identified through other treating physicians were considered valid compared to 28% identified through study physician claims.</p> <p>Conclusion</p> <p>Automation of an inter-institutional problem list added over half of all validated problems to the health problem list of which 12% were generated by conditions treated by other physicians. Automating the integration of existing information sources provides timely access to accurate and relevant health problem information. It may also accelerate the uptake and use of electronic medical record systems.</p
Dielectric 5-Branes and Giant Gravitons in ABJM
We construct a supersymmetric NS5-brane wrapped on a twisted 5-sphere
expanding in the in , with D0-brane charge. This
configuration provides a realization of the stringy exclusion principle in
terms of giant D0-branes. In the maximal case the twisted 5-sphere reduces to a
and its energy can be accounted for both by a bound state of
D4-branes wrapping the and a bound state of D0-branes, a realization
on the gravity side of the symmetry of Young diagrams with rows and
columns. We discuss some generalizations of this configuration in M-theory
carrying angular momentum, some of them with an interpretation as giant
gravitons. We provide the microscopical description that allows to explore the
region of finite 't Hooft coupling.Comment: 26 pages, reference adde
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma
Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett’s esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analysis was employed to evaluate pathway-level and gene-level associations with BE/EAC, using genotypes for 270 single-nucleotide polymorphisms (SNPs) in or near 12 IGF-related genes, ascertained from 3295 BE cases, 2515 EAC cases and 3207 controls in the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) GWAS. Gene-level signals were assessed using Multi-marker Analysis of GenoMic Annotation (MAGMA) and SNP summary statistics from BEACON and an expanded GWAS meta-analysis (6167 BE cases, 4112 EAC cases, 17 159 controls). Global variation in the IGF pathway was associated with risk of BE (P = 0.0015). Gene-level associations with BE were observed for GHR (growth hormone receptor; P = 0.00046, false discovery rate q = 0.0056) and IGF1R (IGF1 receptor; P = 0.0090, q = 0.0542). These gene-level signals remained significant at q < 0.1 when assessed using data from the largest available BE/EAC GWAS meta-analysis. No significant associations were observed for EAC. This study represents the most comprehensive evaluation to date of inherited genetic variation in the IGF pathway and BE/EAC risk, providing novel evidence that variation in two genes encoding cell-surface receptors, GHR and IGF1R, may influence risk of BE
The BPS spectrum of monopole operators in ABJM: towards a field theory description of the giant torus
We study the BPS spectrum of monopole operators in ABJM theory. First we work
out the complete spectrum of the chiral ring by using a semiclassical analysis
of the field theory compactified on a two sphere. By properly taking into
account the full quantization condition of monopole charges, we show that the
moduli space of ABJM theory with Chern-Simons level k, -k is a particular Z_k
cover of the symmetric product of C^4/Z_k. We also work out in detail the
spectrum of fluctuations around half-BPS monopole configurations and we find
candidate states for a dual BPS configuration to the giant torus solution found
by Nishioka and Takayanagi in the supergravity limit. We also discuss more
general BPS states.Comment: 33 pages, JHEP style. v2: added reference, fixed typos. v3: added
references, improved the discussion of various issue
Cost-effectiveness and budget impact analyses of a colorectal cancer screening programme in a high adenoma prevalence scenario using MISCAN-Colon microsimulation model
This economic evaluation showed a screening intervention with a major health gain that also produced net savings when a long follow-up was used to capture the late economic benefit. The number of colonoscopies required was high but remain within the capacity of the Basque Health Service. So far in Europe, no other population Colorectal Cancer screening programme has been evaluated by budget impact analysis
- …