39 research outputs found

    Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

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    The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer

    Summary of beryllium specifications

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    This report summarizes and compares the main beryllium properties included in producer, Department of Energy (formerly ERDA) facility, and government specifications. These data are tabulated in a sequence established primarily by increasing purity and secondarily by increasing tensile properties. Comments on formability and weldability are also included

    Confocal scanning optical microscopy and related imaging systems

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    Includes bibliographical references and index

    Casting large beryllium ingots

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    Beryllium casting is a relatively new technology with the successful cast of large ingots being developed during the last decade. In 1961, Rocky Flats initiated a beryllium ingot-sheet fabrication process that included the development of new techniques to consistently cast large sound beryllium ingots. This report reviews the casting technology that was developed to cast these beryllium ingots on a production basis along with some of the remaining technical problems requiring additional development work

    Literature on fabrication of tungsten for application in pyrochemical processing of spent nuclear fuels

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    The pyrochemical processing of nuclear fuels requires crucibles, stirrers, and transfer tubing that will withstand the temperature and the chemical attack from molten salts and metals used in the process. This report summarizes the literature that pertains to fabrication (joining, chemical vapor deposition, plasma spraying, forming, and spinning) is the main theme. This report also summarizes a sampling of literature on molbdenum and the work previously performed at Argonne National Laboratory on other container materials used for pyrochemical processing of spent nuclear fuels
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