The Normal Physiological Aspects of Aging as They Relate to Nurse Aid Care

The education of caregivers is essential to proper care. The retention of nurse aids in long-term care of the elderly can be enhanced by specific instruction in the physical aspects of aging as it relates to the required care. The educational level of nurse aids may not give them the perspective needed to interpret the changes they see taking place in the elderly. This paper provides some of that additional perspective. Aging changes begin at the cellular level Cell tasks are specific and functional Aging effects changes in cell function and response with subsequent visible and experienced signs and symptoms of aging. Anatomical and physiological age-related changes are the subsequent result of the overall, ongoing aging process. The body systems are interrelated and interdependent. Skin and hair require a change in the aid care as they become dry and thin. The musculoskeletal ~stem changes result in. a loss of strength and height, and includes some visual changes, all of which require special aid attention. The nervous system changes result in a slowing of the response time to stimuli The endocrine system oversees many of the age related changes. The endocrine system as well as the respiratory and circulatory systems, have few functions that the nurse aid can directly influence, yet the changes require knowledgeable aid care. The digestive and urinary systems are two of the systems most apparently affected as we age and aid knowledge of the changes can be of great assistance to the elderly. The reproductive system slowly undergoes changes in both the male and female. Aid awareness of these changes will yield better care for the elderly

Performance and Retention of Female Engineering Students when Placed in a Gender Parity Course

Though women earn the majority of bachelor’s degrees in the United States of America, they are in the vast minority of those earning degrees in engineering, only 24%. In an effort to ultimately increase the number of women graduating with degrees in engineering, our study focused on improving the retention of first-year female students. We set out to discover if female engineering students, who traditionally are in the minority of their student body, would have an increase in their performance and retention when placed in a manipulated course environment of gender parity (50% women, 50% men). Our study followed 129 first-year female engineering students in Fall 2017 and Fall 2018 through their first academic term where they were enrolled in the initial engineering course at Louisiana Tech University. As a result of this study, we found no significance associated with the implementation of gender parity sections of a first-year engineering course on participants’ performance and retention. After uncovering these initial results, we further investigated other potential factors affecting retention, including Composite ACT scores, Math ACT scores, overall high school grade point average, and midterm exam grades, resulting in insightful information

Inhibitory control mechanisms and their role in task switching: A multi-methodological approach

Executive control allows us to ignore distraction and switch between tasks in a flexible, yet organized fashion. While a hallmark of controlled behavior, distinctions among executive control processes are not thoroughly agreed upon. The present work explored the organization of two of these executive control processes, inhibition and shifting, and their relationship to each other. There were two primary goals. The first goal was to investigate the distinction among inhibitory control processes, as “inhibition” has oftentimes been considered a unitary construct. For example, there is evidence that response-distractor inhibition, which involves resolving interference from dominant responses or distractors in the external environment, is different from resistance to proactive interference (PI), which involves overcoming interference from previously relevant representations in memory. Using aging, neuropsychology, and individual differences methodologies, I investigated the unity and diversity of inhibitory control mechanisms. The healthy aging and neuropsychological evidence supported a distinction between response-distractor inhibition and resistance to proactive interference. However, when controlling for processing speed, the individual differences work suggested a need for further specification, as only a subset of these tasks emerged in the single factor model that provided the best fit to the data. The second goal was to explore how inhibitory control processes interact with task switching, as some theoretical accounts of task switching have suggested that switch costs result from the need to overcome interference from the previously relevant task. Inconsistent with these theories, I found little relation between inhibitory control and measures of global and local task switching, and instead, working memory served as the best predictor of these shifting measures. In contrast, inhibitory control was related to the backward inhibition abilities of older adults. These findings are discussed within a theory of working memory that accounts for the patterns of results found across the different methodologies

Task switching and short-term retention: The role of memory load in task switching performance

Shifting, which is the process of switching task sets between two or more tasks, incurs a cost: participants are slower and more error prone when a switch is required, relative to when the same task is performed in a sequential manner. Recent research in our lab has found a performance dissociation between two task switching paradigms in ML, a patient with reduced short-term memory (STM) capacity. The present study investigates the hypothesis that this dissociation is a result of memory load differences between the two shifting paradigms. We tested this hypothesis by measuring shifting abilities in patients with phonological and semantic short-term memory deficits, as well as age-matched controls under standard and articulatory suppression conditions. The results suggest that task-related memory demands impair the shifting performance of patients with STM deficits, and that phonological (but not semantic) retention contributes to shifting as task requirements increase

The B[e] phenomenon in the Milky Way and Magellanic Clouds

Discovered over 30 years ago, the B[e] phenomenon has not yet revealed all its puzzles. New objects that exhibit it are being discovered in the Milky Way, and properties of known objects are being constrained. We review recent findings about objects of this class and their subgroups as well as discuss new results from studies of the objects with yet unknown nature. In the Magellanic Clouds, the population of such objects has been restricted to supergiants. We present new candidates with apparently lower luminosities found in the LMC.Comment: 5 pages, 2 figures, IAU Symposium 272, Active OB stars: structure, evolution, mass loss and critical limit

Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats

Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features of late stage chronic kidney disease-mineral bone disorder (CKD-MBD), specifically the development of cortical bone porosity. However, progression of disease in female Cy/+ rats, assessed in limited studies, is more heterogeneous and to date has failed to show development of the CKD-MBD phenotype, thus limiting their use as a practical model of progressive CKD-MBD. Animal and human studies suggest that estrogen may be protective against kidney disease in addition to its established protective effect on bone. Therefore, in this study, we aimed to determine the effect of ovariectomy (OVX) on the biochemical and skeletal manifestations of CKD-MBD in Cy/+ female rats. We hypothesized that OVX would accelerate development of the biochemical and skeletal features of CKD-MBD in female Cy/+ rats, similar to those seen in male Cy/+ rats. Female Cy/+ rats underwent OVX (n = 8) or Sham (n = 8) surgery at 15 weeks of age. Blood was collected every 5 weeks post-surgery until 35 weeks of age, when the rats underwent a 4-day metabolic balance, and the tibia and final blood were collected at the time of sacrifice. OVX produced the expected changes in trabecular and cortical parameters consistent with post-menopausal disease, and negative phosphorus balance compared with Sham. However, indicators of CKD-MBD were similar between OVX and Sham (similar kidney weight, plasma blood urea nitrogen, creatinine, creatinine clearance, phosphorus, calcium, parathyroid hormone, and no cortical porosity). Contrary to our hypothesis, OVX did not produce evidence of development of the CKD-MBD phenotype in female Cy/+ rats

The myriad challenges of the Paris Agreement

The much awaited and intensely negotiated Paris Agreement was adopted on 12 December 2015 by the Parties to the United Nations Framework Convention on Climate Change. The agreement set out a more ambitious long-term temperature goal than many had anticipated, implying more stringent emissions reductions that have been under-explored by the research community. By its very nature a multidisciplinary challenge, filling the knowledge gap requires not only climate scientists, but the whole Earth system science community, as well as economists, engineers, lawyers, philosophers, politicians, emergency planners and others to step up. To kick start cross-disciplinary discussions, the University of Oxford's Environmental Change Institute focused its 25th anniversary conference upon meeting the challenges of the Paris Agreement for science and society. This theme issue consists of review papers, opinion pieces and original research from some of the presentations within that meeting, covering a wide range of issues underpinning the Paris Agreement

Positive impact of low-dose, high-energy radiation on bone in partial- and/or full-weightbearing mice

Astronauts traveling beyond low Earth orbit will be exposed to galactic cosmic radiation (GCR); understanding how high energy ionizing radiation modifies the bone response to mechanical unloading is important to assuring crew health. To investigate this, we exposed 4-mo-old female Balb/cBYJ mice to an acute space-relevant dose of 0.5 Gy 56Fe or sham (n = ~8/group); 4 days later, half of the mice were also subjected to a ground-based analog for 1/6 g (partial weightbearing) (G/6) for 21 days. Microcomputed tomography (µ-CT) of the distal femur reveals that 56Fe exposure resulted in 65-78% greater volume and improved microarchitecture of cancellous bone after 21 d compared to sham controls. Radiation also leads to significant increases in three measures of energy absorption at the mid-shaft femur and an increase in stiffness of the L4 vertebra. No significant effects of radiation on bone formation indices are detected; however, G/6 leads to reduced % mineralizing surface on the inner mid-tibial bone surface. In separate groups allowed 21 days of weightbearing recovery from G/6 and/or 56Fe exposure, radiation-exposed mice still exhibit greater bone mass and improved microarchitecture vs. sham control. However, femoral bone energy absorption values are no longer higher in the 56Fe-exposed WB mice vs. sham controls. We provide evidence for persistent positive impacts of high-LET radiation exposure preceding a period of full or partial weightbearing on bone mass and microarchitecture in the distal femur and, for full weightbearing mice only and more transiently, cortical bone energy absorption values

Stress Hormone Cortisol relates to Emotion Expression for Young Children facing Economic Hardship

Background: Around 40% of children in the US face economic hardship. Related stressors influence physiological functioning and brain development, with implications for cognitive and social-emotional functioning. The hormone cortisol indicates stress levels, yet because cortisol responses to current stressors are imposed on baseline levels, the meaning of cortisol as measured on a particular occasion often is unclear: both elevated and depressed cortisol levels can indicate problematic dysregulation. The present study aims to elucidate how cortisol levels relate to expressed emotion for children attending Head Start preschool. Participants: Participants included 70 children attending a Head Start preschool in Philadelphia, PA. Mean age was 4 years, 1 month, and 52.3% were female, 54.5% Black/African American, 15.2% Latino/Hispanic American, 10.3% Asian American, and 20.0% Caucasian/European American. Procedure: Ethical standards were followed, and all procedures were approved by the WCU IRB. The study included: (1) parent demographic interviews at the start of the school year; (2) measurement of child cortisol levels via salivary assay at four times of day on six different days across the school year; (3) coding of children’s emotion expression in their preschool classes directly prior to the measurement of cortisol, using a well validated observational system called AFFEX (Izard, Dougherty, & Hembree, 1989). Results and implications: Preliminary zero-order correlational analyses indicated that children’s expression of sadness was uniquely correlated with elevations in cortisol. No significant relations were indicated for other types of emotion expression. Implications concern understanding how child cortisol levels relate to observed emotions in preschool context

Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study

Patients with chronic kidney disease (CKD) have accelerated bone loss, vascular calcification and abnormal biochemistries, together contributing to an increased risk of cardiovascular disease and fracture-associated mortality. Despite evidence of vascular pathologies and dysfunction in CKD, our group has shown that cortical bone tissue perfusion is higher in a rat model of high-turnover CKD. The goal of the present study was to test the hypothesis that parathyroid hormone (PTH) suppressive interventions would normalize cortical bone vascular perfusion in the setting of CKD. In two separate experiments, 35-week old CKD animals and their normal littermates, underwent intra-cardiac fluorescent microsphere injection to assess the effect of 10 weeks of PTH suppression (Experiment 1: calcium supplementation, Experiment 2: calcimimetic treatment) on alterations in bone tissue perfusion. In Experiment 1, CKD animals had serum blood urea nitrogen (BUN) and PTH levels significantly higher than NL (+182% and +958%; p<0.05). CKD+Ca animals had BUN levels that were similar to CKD, while PTH levels were significantly lower and comparable to NL. Both femoral cortex (+220%, p=0.003) and tibial cortex (+336, p=0.005) tissue perfusion were significantly higher in CKD animals when compared to NL; perfusion was normalized to those of NL in CKD+Ca animals. MicroCT analysis of the proximal tibia cortical porosity showed a trend toward higher values in CKD (+401%; p=0.017) but not CKD+Ca (+111%; p = 0.38) compared to NL. Experiment 2, using an alternative method of PTH suppression, showed similar results as those of Experiment 1. These data demonstrate that PTH-suppression based interventions normalize cortical bone perfusion in the setting of CKD.This work was supported by a United States (U.S.) Department of Veterans Affairs grant (BX003025) to MRA. MWA was supported by F30 DK115162 and T32 AR065971 during separate portions of this work. KP-2326 was provided through a material transfer agreement with Amgen