Special Article: Physical Activity, Physical Fitness, and Cardiovascular Risk Factors in Childhood

In adults, physical activity and exercise training are associated with reduced cardiovascular morbidity and mortality, a reduced likelihood of developing adverse cardiovascular risk factors, and improved insulin sensitivity. In childhood, participation in appropriate physical activity may prevent the development of cardiovascular risk factors in the future and complement treatment of existing cardiovascular risk factors, including hypertension, dyslipidemia, and overweight. Exercise in children can also significantly improve insulin sensitivity independent of weight loss. These e fects are mediated in overweight children by increases in lean body mass relative to fat mass and associated improvements in inflammatory mediators, endothelial function, and the associated adverse hormonal milieu

Design and modeling of a periodic single-phase sandwich panel for acoustic insulation applications

Sandwich and composite panels are widely adopted in acoustic applications due to their sound insulation properties that overcome mass-law-based partitions in medium–high frequency regions. A key aspect in the design procedure of acoustic panels is the control of the resonance-dominated region of the sound transmission loss (STL) curve. Within that frequency range, such systems usually show acoustic weakness and poor insulation performances with respect to standard single-layer solutions. In the present contribution, we want to highlight an innovative approach to the sandwich partition concept. A novel single-phase sandwich panel is realized by adopting a periodic repetition of a properly designed unit cell. The resulting internal truss structure is self-sustained, and its mechanical stiffness can be tuned to maximize the STL in the resonance-dominated region. A set of parametric analyses is reported to show how the topology of the unit cell affects the noise reduction properties of the panel. Experimental validation is performed on a nylon 3D-printed prototype. The proposed panel is then integrated with some locally resonant elements that can be adopted to further improve the low-frequency STL of the solution. Industrial and production considerations are also taken into account during the design process to make the solution industrially valid with a circular economy focus

An Exploratory Study of Suboxone (Buprenorphine/ Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability

Suboxone films are U.S. Food and Drug Administration approved to treat opioid dependence. While the package insert states that films should not be cut, physicians often prescribe film fractions for treatment and tapering. There is no data to support this practice, and this study was initiated to evaluate cutting methods, content uniformity, and stability of split films. Suboxone 8-mg buprenorphine/2-mg naloxone films were split using four methods: 1) ruler/razor cut, 2) scissor cut, 3) fold/rip, and 4) fold/scissor cut. United States Pharmacopeia Chapter \u3c905\u3e was used to evaluate the weight variation and content uniformity of split films. The stability of split films stored in polybags was evaluated over 7 days. A stability-indicating high-performance liquid chromatography method was used for content uniformity and stability evaluation. The weight variation results were acceptable for the half films from all four cutting methods, but this was not true for the quarter films. The method of ruler/razor cut was determined most favorable and used for the content uniformity test. Based on the high-performance liquid chromatography results, the half films from the ruler/razor cut method met the passing criteria of United States Pharmacopeia Chapter \u3c905\u3e with acceptance values of 9.8 to 10.4 for buprenorphine and 8.4 to 11.5 for naloxone (≤15 is considered passing). The stability results indicated that both actives retained \u3e97.7% of initial strength. Four cutting methods were found to be acceptable for splitting Suboxone films into half but not quarter fractions. The half films from the ruler/razor cut method also passed United States Pharmacopeia Chapter \u3c905\u3e content uniformity test. Both actives remained stable for 7 days when the half films were stored in polybags at room temperature

Physically-based reduced order modelling of a uni-axial polysilicon MEMS accelerometer

In this paper, the mechanical response of a commercial off-the-shelf, uni-axial polysilicon MEMS accelerometer subject to drops is numerically investigated. To speed up the calculations, a simplified physically-based (beams and plate), two degrees of freedom model of the movable parts of the sensor is adopted. The capability and the accuracy of the model are assessed against three-dimensional finite element simulations, and against outcomes of experiments on instrumented samples. It is shown that the reduced order model provides accurate outcomes as for the system dynamics. To also get rather accurate results in terms of stress fields within regions that are prone to fail upon high-g shocks, a correction factor is proposed by accounting for the local stress amplification induced by re-entrant corners

Attention Mechanism-Driven Sensor Placement Strategy for Structural Health Monitoring

Automated vibration-based structural health monitoring (SHM) strategies have been recently proven to be promising in the presence of aging and material deterioration threatening the safety of civil structures. Within such a framework, ensuring high-quality and informative data is a critical aspect that is highly dependent on the deployment of the sensors in the network and on their capability to provide damage-sensitive features to be exploited. This paper presents a novel data-driven approach to the optimal sensor placement devised to identify sensor locations that maximize the information effectiveness for SHM purposes. The optimization of the sensor network is addressed by means of a deep neural network (DNN) equipped with an attention mechanism, a state-of-the-art technique in natural language processing (NLP) that is useful in focusing on a limited number of important components in the information stream. The trained attention mechanism eventually allows for quantifying the relevance of each sensor in terms of the so-called attention scores, thereby enabling to identify the most useful input channels to solve the relevant downstream SHM task. With reference to the damage localization task, framed here as a classification problem handling a set of predefined damage scenarios, the DNN is trained to locate damage on labeled data that had been simulated to emulate the effects of damage under different operational conditions. The capabilities of the proposed method are demonstrated by referring to an eight-story shear building, characterized by damage states possibly located at any story and of unknown severity

A top-down, three-scale numerical analysis of wafer-to-wafer metallic bonding

To study the sensitivity to micro-scale imperfections of the strength of a metallic, wafer-to-wafer MEMS bonding, we propose a three-scale numerical (finite element) approach. At the wafer level (macro-scale), accounting for the whole metallic sealing through nonlinear springs connecting the two silicon wafers modelled as thin plates, we link the force transferred by each single MEMS die to the external pressure applied to the wafers. This force is next used as an index for the input pressure at the die level (meso-scale), where the geometry of the metallic rings is accurately described: the local stress field at the interface between the upper and lower metallic rings is so obtained. Finally, a local (micro-scale) model is used to link the aforementioned local stress field in each die to the bonding strength: representative volumes of the rings getting into contact, accounting in a statistically way for the relevant surface roughness (which is on the order or tens of nanometers at most), are adopted to obtain the relationship between the external pressure and the percentage of sealed area. This information is exploited to assess the properties of the rings, in terms of expected bonding strength

An Experimental and Numerical Study on Glass Frit Wafer-to-Wafer Bonding

A thermo-mechanical wafer-to-wafer bonding process is studied through experiments on the glass frit material and thermo-mechanical numerical simulations to evaluate the effect of the residual stresses on the wafer warpage. To experimentally characterize the material, confocal laser profilometry and scanning electron microscopy for surface observation, energy dispersive X-ray spectroscopy for microstructural investigation, and nanoindentation and die shear tests for the evaluation of mechanical properties are used. An average effective Young’s modulus of 86.5 ± 9.5 GPa, a Poisson’s ratio of 0.19 ± 0.02, and a hardness of 5.26 ± 0.8 GPa were measured through nanoindentation for the glass frit material. The lowest nominal shear strength ranged 1.13 ÷ 1.58 MPa in the strain rate interval to 0.33 ÷ 4.99 × 10 (Formula presented.) s (Formula presented.). To validate the thermo-mechanical model, numerical results are compared with experimental measurements of the out-of-plane displacements at the wafer surface (i.e., warpage), showing acceptable agreement

Self-induced parametric amplification arising from nonlinear elastic coupling in a micromechanical resonating disk gyroscope

Parametric amplification, resulting from intentionally varying a parameter in a resonator at twice its resonant frequency, has been successfully employed to increase the sensitivity of many micro- and nano-scale sensors. Here, we introduce the concept of self-induced parametric amplification, which arises naturally from nonlinear elastic coupling between the degenerate vibration modes in a micromechanical disk-resonator, and is not externally applied. The device functions as a gyroscope wherein angular rotation is detected from Coriolis coupling of elastic vibration energy from a driven vibration mode into a second degenerate sensing mode. While nonlinear elasticity in silicon resonators is extremely weak, in this high quality-factor device, ppm-level nonlinear elastic effects result in an order-of-magnitude increase in the observed sensitivity to Coriolis force relative to linear theory. Perfect degeneracy of the primary and secondary vibration modes is achieved through electrostatic frequency tuning, which also enables the phase and frequency of the parametric coupling to be varied, and we show that the resulting phase and frequency dependence of the amplification follow the theory of parametric resonance. We expect that this phenomenon will be useful for both fundamental studies of dynamic systems with low dissipation and for increasing signal-to-noise ratio in practical applications such as gyroscopes

Experimental verification of a bridge-shaped, nonlinear vibration energy harvester

This paper reports a comprehensive modeling and experimental characterization of a bridge shaped nonlinear energy harvester. A doubly clamped beam at large deflection requires stretching strain in addition to the bending strain to be geometrically compatible, which stiffens the beam as the beam deflects and transforms the dynamics to a nonlinear regime. The Duffing mode non-linear resonance widens the frequency bandwidth significantly at higher frequencies than the linear resonant frequency. The modeling includes a nonlinear measure of strain coupled with piezoelectric constitutive equations which end up in nonlinear coupling terms in the equations of motion. The main result supports that the power generation is bounded by the mechanical damping for both linear and nonlinear harvesters. Modeling also shows the power generation is over a wider bandwidth in the nonlinear case. A prototype is manufactured and tested to measure the power generation at different load resistances and acceleration amplitudes. The prototype shows a nonlinear behavior with well-matched experimental data to the modeling

Interpretation of intraoperative parathyroid hormone monitoring according to the Rome criterion in primary hyperparathyroidism

Intraoperative parathyroid hormone dosage allows real-time monitoring of the decrease in PTH levels during parathyroidectomy and verify procedure’s efficacy. Currently, none of the interpretative criteria used has absolute accuracy. The aim of this study is to evaluate diagnostic accuracy of the Rome criterion verifying diagnostic significance of the individual assays. A total of 205 patients with primary hyperparathyroidism from a single adenoma were retrospectively evaluated and monitored with baseline PTH, PTH at 10 min and PTH at 20 min after adenoma excision. The accuracy of the latter two assays compared with baseline was compared by ROC curves. In addition, was evaluated the influence on these data of localization diagnostics (ultrasounds and scintigraphy), definitive histology, and type of surgery performed. The ratio of 20-min sampling to baseline in the Rome criterion showed highest diagnostic significance. This finding was not influenced by the type of surgery performed, definitive histologic examination, or intraoperative localization of the adenoma. The Rome criterion has shown its high reliability in detecting persistence. The ratio of sampling at 20 min to baseline is by far the best performing. Further studies are needed to evaluate whether sampling at 10 min after adenoma excision can be considered not mandatory